The Response Of A Sense Organ To A Harmonic Stimulus

1952 ◽  
Vol 29 (2) ◽  
pp. 220-234
Author(s):  
J. W. S. PRINGLE ◽  
V. J. WILSON
Keyword(s):  
Nervous System ◽  
Transfer Function ◽  
Dynamic Properties ◽  
Sensory Nerve ◽  
Low Frequency ◽  
Sense Organ ◽  
Peak Frequency ◽  
Mechanical Stimulus ◽  
Sensory Response ◽  
Reflex Arc

1. The response is described of the tactile ending in a femoral spine of the leg of Periplaneta to a harmonic (sinusoidal) mechanical stimulus of low frequency. The peak frequency of impulses in the sensory nerve precedes the maximum tension of the stimulus. 2. This result is shown to be a corollary of the adaptation shown by the sensory response to a transient stimulus. 3. The concept of the ‘transfer function’ is discussed in relation to neurophysiology. Its value is explained as a means of describing the dynamic properties of component parts of the nervous system when the objective is an understanding of the functioning of the complete reflex arc.

scholarly journals Dynamics and Protein–Solvent Interactions of Hemoglobin in T and R Quaternary Conformation

2002 ◽  
Vol 16 (3-4) ◽  
pp. 227-233 ◽  
Author(s):  
Chiara Caronna ◽  
Antonio Cupane
Keyword(s):  
Quaternary Structure ◽  
Dynamic Properties ◽  
Low Frequency ◽  
Helical Structure ◽  
Blue Shift ◽  
Peak Frequency ◽  
The Other ◽  
Solvent Interactions ◽  
Reported Data ◽  
Increasing Temperature

In this work we report the thermal behaviour of the amide I′ band of carbonmonoxy and deoxy hemoglobin in 65% v/v glycerolD8/D2O solutions and in the temperature interval 10–295 K. Following recent suggestions in the literature, we analyze the amide I′ band in terms of two components, one at about 1630 cm−1and the other at about 1650 cm−1, that are assigned to solvent‒exposed and buried α‒helical regions, respectively.For deoxy hemoglobin (in T quaternary structure) both components are narrower with respect to carbonmonoxy hemoglobin (in R quaternary structure), while the peak frequency blue shift observed, upon increasing temperature, for the component at about 1630 cm−1is smaller. The reported data provide evidence of the dependence of hemoglobin dynamic properties upon the protein quaternary structure and suggest a more compact α‒helical structure of hemoglobin in T conformation, with reduced population of low‒frequency modes involving the solvent and protein.

scholarly journals Selective quantification of the cardiac sympathetic and parasympathetic nervous systems by multisignal analysis of cardiorespiratory variability

2008 ◽  
Vol 294 (1) ◽  
pp. H362-H371 ◽  
Author(s):  
Xiaoxiao Chen ◽  
Ramakrishna Mukkamala
Keyword(s):  
Nervous System ◽  
Transfer Function ◽  
Parasympathetic Nervous System ◽  
Transfer Functions ◽  
Low Frequency ◽  
Sympathetic Blockade ◽  
Nervous Systems ◽  
Autonomic Nervous ◽  
Arterial Blood ◽  
The Time Domain

Heart rate (HR) power spectral indexes are limited as measures of the cardiac autonomic nervous systems (CANS) in that they neither offer an effective marker of the β-sympathetic nervous system (SNS) due to its overlap with the parasympathetic nervous system (PNS) in the low-frequency (LF) band nor afford specific measures of the CANS due to input contributions to HR [e.g., arterial blood pressure (ABP) and instantaneous lung volume (ILV)]. We derived new PNS and SNS indexes by multisignal analysis of cardiorespiratory variability. The basic idea was to identify the autonomically mediated transfer functions relating fluctuations in ILV to HR (ILV→HR) and fluctuations in ABP to HR (ABP→HR) so as to eliminate the input contributions to HR and then separate each estimated transfer function in the time domain into PNS and SNS indexes using physiological knowledge. We evaluated these indexes with respect to selective pharmacological autonomic nervous blockade in 14 humans. Our results showed that the PNS index derived from the ABP→HR transfer function was correctly decreased after vagal and double (vagal + β-sympathetic) blockade ( P < 0.01) and did not change after β-sympathetic blockade, whereas the SNS index derived from the same transfer function was correctly reduced after β-sympathetic blockade in the standing posture and double blockade ( P < 0.05) and remained the same after vagal blockade. However, this SNS index did not significantly decrease after β-sympathetic blockade in the supine posture. Overall, these predictions were better than those provided by the traditional high-frequency (HF) power, LF-to-HF ratio, and normalized LF power of HR variability.

On the nonlinear transfer of energy in the peak of a gravity-wave spectrum. II

1976 ◽  
Vol 348 (1655) ◽  
pp. 467-483 ◽  
Keyword(s):  
Transfer Function ◽  
Water Waves ◽  
Transfer Equation ◽  
Negative Transfer ◽  
Wave Spectrum ◽  
Low Frequency ◽  
Multiple Integral ◽  
Peak Frequency ◽  
Two Dimensional ◽  
Nonlinear Transfer

This paper presents the first accurate calculations of the nonlinear transfer of energy within a continuous spectrum of water waves. The spectrum is assumed to be narrow, that is, the wave energy is initially concentrated near one particular wavenumber, and use is made of the transfer equation derived previously in part I (Longuet-Higgins 1975) for this case. It is shown that when the spectrum is describable as a sum of normal distributions, then the sixfold multiple integral can be reduced to a single integration. Hence the accurate evaluation of the energy transfer (as a function of the two dimensional wavenumber) becomes practicable. For a symmetric normal spectrum it is found that the transfer function generally has the form of a clover-leaf, with four maxima lying in the characteristic directions dλ = ±√2 d μ , as seen from the peak. These are separated by troughs of negative transfer lying in the axial directions dλ = 0, d μ = 0. For a typically asymmetric spectrum, one of the negative troughs may be filled in, so that the transfer function more closely resembles a butterfly. An interpretation is given in terms of the balance of terms in the transfer equation. The (one dimensional) transfer function for the frequency-spectrum can be found by integration of the two dimensional transfer function. Typically it has a pronounced minimum near the peak frequency, indicat­ing strong negative transfer there, and two weaker maxima, one on each side. For asymmetric spectra, the maximum transfer is greater on the steeper face of the spectrum, usually on the low-frequency side. A com­parison with the rough calculations of Sell & Hasselmann (1972) for the JONSWAP R3C spectrum shows good agreement.

scholarly journals 82 Struggle behavior and vocalizations of male piglets during castration

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 3-4
Author(s):  
Maria E Lou ◽  
Yuzhi Li ◽  
Beth Ventura
Keyword(s):  
Birth Weight ◽  
Acute Pain ◽  
High Frequency ◽  
Video Recording ◽  
Low Frequency ◽  
Peak Frequency ◽  
Analysis Software ◽  
Chi Square ◽  
Behavioral Indicators ◽  
Treatment Groups

Abstract Castration without the use of analgesia is routinely performed on male piglets. The objective of this study was to assess acute pain during castration through behavioral indicators. Piglets (n=88) were randomly allocated to one of two treatments: castration without the use of analgesia (C) and sham-castration (S). Within 24 hours after birth (birth weight = 1.78kg ±0.71), identical procedures were followed for both treatment groups, except sham piglets were not castrated. Struggle behavior (curl ups, leg kicks, and body flailing) and vocalizations were collected via continuous video recording as piglets received treatment from start (first application of scalpel) to end (application of iodine). Vocalization parameters (duration and peak frequency) were analyzed using the Raven Pro: Interactive Sound Analysis Software (Version 1.5). Peak frequency was defined as low (&lt; 1000 Hz) and high (≥ 1000 Hz). Data were analyzed using the Glimmix Procedure of SAS. For struggle behavior, treatment did not affect curl up frequency. However, castrated piglets kicked more frequently than did sham piglets (C=28.8±0.9 vs. S=21.3±0.9 kicks/min; P=0.02). Additionally, 52% of castrated piglets displayed body flailing, whereas only 4.4% of sham piglets displayed the same behavior (Chi-Square = 24.2; P &lt; 0.0001). For vocalizations, no difference was found for duration and peak frequency of low frequency calls. However, castrated piglets responded with more high frequency calls than sham piglets (C=23.6±0.3 vs. S=18.6±0.3 calls/min; P=0.04). High frequency calls tended to be of longer duration for castrated piglets (C=0.45±0.04 vs. S=0.27±0.04 sec/call; P=0.08). Results indicate that castration without the use of analgesia increased the frequency of leg kicks, body failing, and high frequency calls. This suggests that leg kicks, body flailing, and high frequency calls maybe useful behavioral indicators of acute pain in piglets.

Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses

2011 ◽  
Vol 110 (3) ◽  
pp. 789-798 ◽  
Author(s):  
Kaori Ono ◽  
Masako Tsukamoto-Yasui ◽  
Yoshiko Hara-Kimura ◽  
Naohiko Inoue ◽  
Yoshihito Nogusa ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Low Frequency ◽  
Receptor Potential ◽  
Transient Receptor Potential Channel ◽  
Intragastric Administration ◽  
Brown Adipose ◽  
Reflex Arc ◽  
Transient Receptor

The sympathetic thermoregulatory system controls the magnitude of adaptive thermogenesis in correspondence with the environmental temperature or the state of energy intake and plays a key role in determining the resultant energy storage. However, the nature of the trigger initiating this reflex arc remains to be determined. Here, using capsiate, a digestion-vulnerable capsaicin analog, we examined the involvement of specific activation of transient receptor potential (TRP) channels within the gastrointestinal tract in the thermogenic sympathetic system by measuring the efferent activity of the postganglionic sympathetic nerve innervating brown adipose tissue (BAT) in anesthetized rats. Intragastric administration of capsiate resulted in a time- and dose-dependent increase in integrated BAT sympathetic nerve activity (SNA) over 180 min, which was characterized by an emergence of sporadic high-activity phases composed of low-frequency bursts. This increase in BAT SNA was abolished by blockade of TRP channels as well as of sympathetic ganglionic transmission and was inhibited by ablation of the gastrointestinal vagus nerve. The activation of SNA was delimited to BAT and did not occur in the heart or pancreas. These results point to a neural pathway enabling the selective activation of the central network regulating the BAT SNA in response to a specific stimulation of gastrointestinal TRP channels and offer important implications for understanding the dietary-dependent regulation of energy metabolism and control of obesity.

Preparing for the unpredictable: adaptive feedback enhances the response to unexpected communication signals

2012 ◽  
Vol 107 (4) ◽  
pp. 1241-1246 ◽  
Author(s):  
Gary Marsat ◽  
Leonard Maler
Keyword(s):  
Nervous System ◽  
Sensory Input ◽  
Low Frequency ◽  
Excitatory Input ◽  
Negative Image ◽  
Communication Signals ◽  
First Order ◽  
Communication Signal ◽  
Apical Dendrites ◽  
Spike Bursts

To interact with the environment efficiently, the nervous system must generate expectations about redundant sensory signals and detect unexpected ones. Neural circuits can, for example, compare a prediction of the sensory signal that was generated by the nervous system with the incoming sensory input, to generate a response selective to novel stimuli. In the first-order electrosensory neurons of a gymnotiform electric fish, a negative image of low-frequency redundant communication signals is subtracted from the neural response via feedback, allowing unpredictable signals to be extracted. Here we show that the cancelling feedback not only suppresses the predictable signal but also actively enhances the response to the unpredictable communication signal. A transient mismatch between the predictive feedback and incoming sensory input causes both to be positive: the soma is suddenly depolarized by the unpredictable input, whereas the neuron's apical dendrites remain depolarized by the lagging cancelling feedback. The apical dendrites allow the backpropagation of somatic spikes. We show that backpropagation is enhanced when the dendrites are depolarized, causing the unpredictable excitatory input to evoke spike bursts. As a consequence, the feedback driven by a predictable low-frequency signal not only suppresses the response to a redundant stimulus but also induces a bursting response triggered by unpredictable communication signals.

Prediction of Surge Motion Response of Floating Structure Using Kalman Smoother Adaptive Filters Based Time-Domain Volterra Model

2014 ◽  
Vol 660 ◽  
pp. 799-803
Author(s):  
Edwar Yazid ◽  
M.S. Liew ◽  
Setyamartana Parman ◽  
V.J. Kurian ◽  
C.Y. Ng
Keyword(s):  
Time Series ◽  
Transfer Function ◽  
Time Domain ◽  
Adaptive Filters ◽  
Low Frequency ◽  
Volterra Model ◽  
Floating Structure ◽  
Frequency Responses ◽  
Kalman Smoother ◽  
System Output

This work presents an approachto predict the low frequency and wave frequency responses (LFR and WFR) of afloating structure using Kalman smoother adaptive filters based time domain Volterramodel. This method utilized time series of a measured wave height as systeminput and surge motion as system output and used to generate the linear andnonlinear transfer function (TFs). Based on those TFs, predictions of surgemotion in terms of LFR and WFR were carried out in certain frequency ranges ofwave heights. The applicability of the proposed method is then applied in ascaled 1:100 model of a semisubmersible prototype.

scholarly journals Temporal Interactions of Air-Puff–Evoked Blinks and Saccadic Eye Movements: Insights Into Motor Preparation

2005 ◽  
Vol 93 (3) ◽  
pp. 1718-1729 ◽  
Author(s):  
Neeraj J. Gandhi ◽  
Desiree K. Bonadonna
Keyword(s):  
Eye Movement ◽  
Target Location ◽  
Low Frequency ◽  
Saccadic Eye Movements ◽  
Stimulus Presentation ◽  
Motor Preparation ◽  
Threshold Level ◽  
Saccade Latency ◽  
Sensory Response ◽  
Temporal Interactions

Following the initial, sensory response to stimulus presentation, activity in many saccade-related burst neurons along the oculomotor neuraxis is observed as a gradually increasing low-frequency discharge hypothesized to encode both timing and metrics of the impending eye movement. When the activity reaches an activation threshold level, these cells discharge a high-frequency burst, inhibit the pontine omnipause neurons (OPNs) and trigger a high-velocity eye movement known as saccade. We tested whether early cessation of OPN activity, prior to when it ordinarily pauses, acts to effectively lower the threshold and prematurely trigger a movement of modified metrics and/or dynamics. Relying on the observation that OPN discharge ceases during not only saccades but also blinks, air-puffs were delivered to one eye to evoke blinks as monkeys performed standard oculomotor tasks. We observed a linear relationship between blink and saccade onsets when the blink occurred shortly after the cue to initiate the movement but before the average reaction time. Blinks that preceded and overlapped with the cue increased saccade latency. Blinks evoked during the overlap period of the delayed saccade task, when target location is known but a saccade cannot be initiated for correct performance, failed to trigger saccades prematurely. Furthermore, when saccade and blink execution coincided temporally, the peak velocity of the eye movement was attenuated, and its initial velocity was correlated with its latency. Despite the perturbations, saccade accuracy was maintained across all blink times and task types. Collectively, these results support the notion that temporal features of the low-frequency activity encode aspects of a premotor command and imply that inhibition of OPNs alone is not sufficient to trigger saccades.

Approximate Analytical Expressions of the Fundamental Peak Frequency and the Amplification Factor of S-wave Transfer Function in a Viscoelastic Layered Model

2018 ◽  
Vol 176 (4) ◽  
pp. 1433-1443
Author(s):  
Tran Thanh Tuan ◽  
Pham Chi Vinh ◽  
Abdelkrim Aoudia ◽  
Truong Thi Thuy Dung ◽  
Daniel Manu-Marfo
Keyword(s):  
Transfer Function ◽  
Amplification Factor ◽  
Peak Frequency ◽  
S Wave ◽  
Layered Model ◽  
Analytical Expressions
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