scholarly journals Acute thermal stress and various heavy metals induce tissue-specific pro- or anti-apoptotic events via the p38-MAPK signal transduction pathway in Mytilus galloprovincialis (Lam.)

2005 ◽  
Vol 208 (23) ◽  
pp. 4427-4436 ◽  
Author(s):  
E. Kefaloyianni
Keyword(s):  
Heavy Metals ◽  
Signal Transduction ◽  
Thermal Stress ◽  
P38 Mapk ◽  
Mytilus Galloprovincialis ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Tissue Specific

CK2 Is Acting Upstream of MEK3/6 as a Part of the Signal Control of ERK1/2 and p38 MAPK during Keratinocytes Autocrine Differentiation

2011 ◽  
Vol 66 (1-2) ◽  
pp. 83-86 ◽  
Author(s):  
Antonia R. Isaeva ◽  
Vanio I. Mitev
Keyword(s):  
Signal Transduction ◽  
P38 Mapk ◽  
Mammalian Cells ◽  
Protein Kinase Ck2 ◽  
Cell Signalling ◽  
Signal Transduction Pathway ◽  
Signal Control ◽  
Transduction Pathway ◽  
Protein Levels ◽  
Kinase Ck2

Protein kinase CK2 (formerly termed “casein kinase II”) is a ubiquitously in mammalian cells distributed Ser/Thr kinase, with global role in cell regulation. Although, the involvement of CK2 in cell signalling is vast-investigated, virtually nothing is known about its contribution to signal control of keratinocytes differentiation. Here we show that, in autocrine differentiating keratinocytes, inhibition of the CK2 activity induced by 4,5,6,7-tetrabromobenzotriazole (TBB) causes reciprocal changes in the activities of major signal transduction regulators of keratinocytes differentiation, i.e. ERK1/2 and p38 MAPK, without affecting their protein levels. The ERK1/2 activity is strongly suppressed, while the activity of p38 is increased. We have also found that the activity of upstream and specifi c for p38 MAPK kinase MEK3/6 is also stimulated by TBB. These original results clearly demonstrate the participation of CK2 in the signal transduction pathway controlling MEK3/6, p38 MAPK, and ERK1/2 in the used model system.

scholarly journals Involvement of the p38 MAPK-NF-κB Signal Transduction Pathway and COX-2 in the Pathobiology of Meniscus Degeneration in Humans

2008 ◽  
Vol 14 (3-4) ◽  
pp. 160-166 ◽  
Author(s):  
Dionysios J. Papachristou ◽  
Eugenia Papadakou ◽  
Efthimia K. Basdra ◽  
Panagiotis Baltopoulos ◽  
Elias Panagiotopoulos ◽  
...  
Keyword(s):  
Signal Transduction ◽  
P38 Mapk ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Meniscus Degeneration ◽  
Cox 2
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