scholarly journals Antimalarial drug discovery: old and new approaches

2003 ◽  
Vol 206 (21) ◽  
pp. 3735-3744 ◽  
Author(s):  
P. J. Rosenthal
Keyword(s):  
Drug Discovery ◽  
Antimalarial Drug ◽  
New Approaches

scholarly journals New approaches in antimalarial drug discovery and development: a review

2012 ◽  
Vol 107 (7) ◽  
pp. 831-845 ◽  
Author(s):  
Anna Caroline C Aguiar ◽  
Eliana MM da Rocha ◽  
Nicolli B de Souza ◽  
Tanos CC França ◽  
Antoniana U Krettli
Keyword(s):  
Drug Discovery ◽  
Antimalarial Drug ◽  
Drug Discovery And Development ◽  
New Approaches

Sitagliptin: a potential drug for the treatment of SARS-CoV-2?

2020 ◽  
Author(s):  
Sanaa Bardaweel
Keyword(s):  
Clinical Trials ◽  
Drug Discovery ◽  
Antimalarial Drug ◽  
Drug Repurposing ◽  
Spike Protein ◽  
Diabetic Patients ◽  
Potential Drug ◽  
Chemokine Production ◽  
Drug Discovery And Development ◽  
Sequence Identity

Recently, an outbreak of fatal coronavirus, SARS-CoV-2, has emerged from China and is rapidly spreading worldwide. As the coronavirus pandemic rages, drug discovery and development become even more challenging. Drug repurposing of the antimalarial drug chloroquine and its hydroxylated form had demonstrated apparent effectiveness in the treatment of COVID-19 associated pneumonia in clinical trials. SARS-CoV-2 spike protein shares 31.9% sequence identity with the spike protein presents in the Middle East Respiratory Syndrome Corona Virus (MERS-CoV), which infects cells through the interaction of its spike protein with the DPP4 receptor found on macrophages. Sitagliptin, a DPP4 inhibitor, that is known for its antidiabetic, immunoregulatory, anti-inflammatory, and beneficial cardiometabolic effects has been shown to reverse macrophage responses in MERS-CoV infection and reduce CXCL10 chemokine production in AIDS patients. We suggest that Sitagliptin may be beneficial alternative for the treatment of COVID-19 disease especially in diabetic patients and patients with preexisting cardiovascular conditions who are already at higher risk of COVID-19 infection.

scholarly journals Design and Synthesis of Inhibitors ofPlasmodium falciparumN-Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery

2012 ◽  
Vol 55 (20) ◽  
pp. 8879-8890 ◽  
Author(s):  
Zhiyong Yu ◽  
James A. Brannigan ◽  
David K. Moss ◽  
A. Marek Brzozowski ◽  
Anthony J. Wilkinson ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Antimalarial Drug ◽  
Design And Synthesis ◽  
Promising Target

scholarly journals Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

Science ◽  
2011 ◽  
Vol 334 (6061) ◽  
pp. 1372-1377 ◽  
Author(s):  
S. Meister ◽  
D. M. Plouffe ◽  
K. L. Kuhen ◽  
G. M. C. Bonamy ◽  
T. Wu ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Antimalarial Drug ◽  
Next Generation

Fatty Acid Synthesis as a Target for Antimalarial Drug Discovery

2005 ◽  
Vol 8 (1) ◽  
pp. 15-26 ◽  
Author(s):  
Jeff Lu ◽  
Patricia Lee ◽  
Norman Waters ◽  
Sean Prigge
Keyword(s):  
Fatty Acid ◽  
Drug Discovery ◽  
Fatty Acid Synthesis ◽  
Antimalarial Drug ◽  
Acid Synthesis

New Approaches to Mechanism Analysis for Drug Discovery Using DNA Microarray Data Combined with KeyMolnet

2005 ◽  
Vol 2 (2) ◽  
pp. 89-98 ◽  
Author(s):  
Hiromi Sato ◽  
Seiichi Ishida ◽  
Kyoko Toda ◽  
Rieko Matsuda ◽  
Yuzuru Hayashi ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Dna Microarray ◽  
Microarray Data ◽  
Mechanism Analysis ◽  
New Approaches ◽  
Dna Microarray Data
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