scholarly journals Design and Synthesis of Inhibitors ofPlasmodium falciparumN-Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery

2012 ◽  
Vol 55 (20) ◽  
pp. 8879-8890 ◽  
Author(s):  
Zhiyong Yu ◽  
James A. Brannigan ◽  
David K. Moss ◽  
A. Marek Brzozowski ◽  
Anthony J. Wilkinson ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Antimalarial Drug ◽  
Design And Synthesis ◽  
Promising Target

Sitagliptin: a potential drug for the treatment of SARS-CoV-2?

2020 ◽  
Author(s):  
Sanaa Bardaweel
Keyword(s):  
Clinical Trials ◽  
Drug Discovery ◽  
Antimalarial Drug ◽  
Drug Repurposing ◽  
Spike Protein ◽  
Diabetic Patients ◽  
Potential Drug ◽  
Chemokine Production ◽  
Drug Discovery And Development ◽  
Sequence Identity

Recently, an outbreak of fatal coronavirus, SARS-CoV-2, has emerged from China and is rapidly spreading worldwide. As the coronavirus pandemic rages, drug discovery and development become even more challenging. Drug repurposing of the antimalarial drug chloroquine and its hydroxylated form had demonstrated apparent effectiveness in the treatment of COVID-19 associated pneumonia in clinical trials. SARS-CoV-2 spike protein shares 31.9% sequence identity with the spike protein presents in the Middle East Respiratory Syndrome Corona Virus (MERS-CoV), which infects cells through the interaction of its spike protein with the DPP4 receptor found on macrophages. Sitagliptin, a DPP4 inhibitor, that is known for its antidiabetic, immunoregulatory, anti-inflammatory, and beneficial cardiometabolic effects has been shown to reverse macrophage responses in MERS-CoV infection and reduce CXCL10 chemokine production in AIDS patients. We suggest that Sitagliptin may be beneficial alternative for the treatment of COVID-19 disease especially in diabetic patients and patients with preexisting cardiovascular conditions who are already at higher risk of COVID-19 infection.

Design and synthesis of mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease

2021 ◽  
pp. 113646
Author(s):  
Iván Beltran-Hortelano ◽  
Richard L. Atherton ◽  
Mercedes Rubio-Hernández ◽  
Julen Sanz-Serrano ◽  
Verónica Alcolea ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Chagas Disease ◽  
Mannich Base ◽  
Design And Synthesis ◽  
Lead Compounds

scholarly journals Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

Science ◽  
2011 ◽  
Vol 334 (6061) ◽  
pp. 1372-1377 ◽  
Author(s):  
S. Meister ◽  
D. M. Plouffe ◽  
K. L. Kuhen ◽  
G. M. C. Bonamy ◽  
T. Wu ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Antimalarial Drug ◽  
Next Generation

Fatty Acid Synthesis as a Target for Antimalarial Drug Discovery

2005 ◽  
Vol 8 (1) ◽  
pp. 15-26 ◽  
Author(s):  
Jeff Lu ◽  
Patricia Lee ◽  
Norman Waters ◽  
Sean Prigge
Keyword(s):  
Fatty Acid ◽  
Drug Discovery ◽  
Fatty Acid Synthesis ◽  
Antimalarial Drug ◽  
Acid Synthesis

Antimalarial Drug Discovery

2013 ◽  
pp. 97-151 ◽  
Author(s):  
Félix Calderón ◽  
David M. Wilson ◽  
Francisco-Javier Gamo
Keyword(s):  
Drug Discovery ◽  
Antimalarial Drug

Phthalimide Analogs for Antimalarial Drug Discovery

2021 ◽  
Author(s):  
Meenakshi Bansal ◽  
Charu Upadhyay ◽  
Poonam Singh ◽  
Sumit Kumar ◽  
Brijesh Rathi
Keyword(s):  
Public Health ◽  
Drug Discovery ◽  
Antimalarial Drug ◽  
Health Concern ◽  
Public Health Concern ◽  
Major Public Health Concern ◽  
The World ◽  
Life Threatening

Malaria remains as one of the most life-threatening diseases and thus major public health concern all around the world. The disease becomes devastating if not treated with proper medication on...

Sign in / Sign up

Export Citation Format

Share Document