scholarly journals Plakophilin 3 phosphorylation by ribosomal S6 kinases supports desmosome assembly

2020 ◽  
Vol 133 (8) ◽  
pp. jcs238295
Author(s):  
Lisa Müller ◽  
Katrin Rietscher ◽  
René Keil ◽  
Marvin Neuholz ◽  
Mechthild Hatzfeld
Keyword(s):  
Plakophilin 3

scholarly journals Evaluation of Plakophilin-3 mRNA as a Biomarker for Detection of Circulating Tumor Cells in Gastrointestinal Cancer Patients

2010 ◽  
Vol 19 (6) ◽  
pp. 1432-1440 ◽  
Author(s):  
Manuel Valladares-Ayerbes ◽  
Silvia Díaz-Prado ◽  
Margarita Reboredo ◽  
Vanessa Medina ◽  
Maria J. Lorenzo-Patiño ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Gastrointestinal Cancer ◽  
Plakophilin 3

scholarly journals Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice

2015 ◽  
Vol 45 (10) ◽  
pp. 2898-2910 ◽  
Author(s):  
Tatyana Sklyarova ◽  
Jolanda van Hengel ◽  
Elien Van Wonterghem ◽  
Claude Libert ◽  
Frans van Roy ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Tissue Specific ◽  
Plakophilin 3

Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering

2019 ◽  
Vol 76 (17) ◽  
pp. 3465-3476 ◽  
Author(s):  
Michael Fuchs ◽  
Marco Foresti ◽  
Mariya Y. Radeva ◽  
Daniela Kugelmann ◽  
Rene Keil ◽  
...  
Keyword(s):  
Plakophilin 3

scholarly journals Plakophilin-3 Catenin Associates with the ETV1/ER81 Transcription Factor to Positively Modulate Gene Activity

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86784 ◽  
Author(s):  
William A. Munoz ◽  
Moonsup Lee ◽  
Rachel K. Miller ◽  
Zamal Ahmed ◽  
Hong Ji ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Gene Activity ◽  
Plakophilin 3

Serum plakophilin-3 autoreactivity in paraneoplastic pemphigus

2010 ◽  
Vol 163 (3) ◽  
pp. 630-632 ◽  
Author(s):  
J. Lambert ◽  
S. Bracke ◽  
F. Van Roy ◽  
H.H. Pas ◽  
S. Bonné ◽  
...  
Keyword(s):  
Paraneoplastic Pemphigus ◽  
Plakophilin 3

c-Src mediated tyrosine phosphorylation of plakophilin 3 as a new mechanism to control desmosome composition in cells exposed to oxidative stress

2014 ◽  
Vol 359 (3) ◽  
pp. 799-816 ◽  
Author(s):  
Steffen Neuber ◽  
Stephanie Jäger ◽  
Merle Meyer ◽  
Viktoria Wischmann ◽  
Peter J. Koch ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tyrosine Phosphorylation ◽  
Plakophilin 3 ◽  
In Cells

Plakophilin 3 – a novel cell-type-specific desmosomal plaque protein

1999 ◽  
Vol 65 (1) ◽  
pp. 71-72
Author(s):  
Ansgar Schmidt ◽  
Lutz Langbein ◽  
Silke Prätzel ◽  
Michaela Rode ◽  
Hans-Richard Rackwitz ◽  
...  
Keyword(s):  
Cell Type ◽  
Cell Type Specific ◽  
Plakophilin 3

scholarly journals Defining desmosomal plakophilin-3 interactions

2003 ◽  
Vol 161 (2) ◽  
pp. 403-416 ◽  
Author(s):  
Stefan Bonné ◽  
Barbara Gilbert ◽  
Mechthild Hatzfeld ◽  
Xinyu Chen ◽  
Kathleen J. Green ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Protein Interaction ◽  
Yeast Two Hybrid ◽  
Binding Properties ◽  
Localization Pattern ◽  
Interaction Sites ◽  
Keratin 18 ◽  
Plakophilin 3 ◽  
Two Hybrid ◽  
Stratified Epithelia

Plakophilin 3 (PKP3) is a recently described armadillo protein of the desmosomal plaque, which is synthesized in simple and stratified epithelia. We investigated the localization pattern of endogenous and exogenous PKP3 and fragments thereof. The desmosomal binding properties of PKP3 were determined using yeast two-hybrid, coimmunoprecipitation and colocalization experiments. To this end, novel mouse anti-PKP3 mAbs were generated. We found that PKP3 binds all three desmogleins, desmocollin (Dsc) 3a and -3b, and possibly also Dsc1a and -2a. As such, this is the first protein interaction ever observed with a Dsc-b isoform. Moreover, we determined that PKP3 interacts with plakoglobin, desmoplakin (DP) and the epithelial keratin 18. Evidence was found for the presence of at least two DP–PKP3 interaction sites. This finding might explain how lateral DP–PKP interactions are established in the upper layers of stratified epithelia, increasing the size of the desmosome and the number of anchoring points available for keratins. Together, these results show that PKP3, whose epithelial and epidermal desmosomal expression pattern and protein interaction repertoire are broader than those of PKP1 and -2, is a unique multiprotein binding element in the basic architecture of a vast majority of epithelial desmosomes.

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