scholarly journals Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice

2015 ◽  
Vol 45 (10) ◽  
pp. 2898-2910 ◽  
Author(s):  
Tatyana Sklyarova ◽  
Jolanda van Hengel ◽  
Elien Van Wonterghem ◽  
Claude Libert ◽  
Frans van Roy ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Tissue Specific ◽  
Plakophilin 3

scholarly journals Early Pulmonary and Systemic Inflammation Leads to Tissue‐Specific Recruitment of Lectin Complement Pathway Initiators

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Ronni Plovsing ◽  
Ronan Berg ◽  
Lea Munthe‐Fog ◽  
Lars Konge ◽  
Martin Iversen ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Complement Pathway ◽  
Tissue Specific

scholarly journals The Effects of Tacrolimus on Tissue-Specific, Protein-Level Inflammatory Networks in Vascularized Composite Allotransplantation

2021 ◽  
Vol 12 ◽  
Author(s):  
Ali Mubin Aral ◽  
Ruben Zamora ◽  
Derek Barclay ◽  
Jinling Yin ◽  
Fayten El-Dehaibi ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Inflammatory Mediators ◽  
Peripheral Blood ◽  
Control Point ◽  
Dynamic Networks ◽  
Principal Component ◽  
Brown Norway ◽  
Vascularized Composite Allotransplantation ◽  
Tissue Specific ◽  
Over Time

Systems-level insights into inflammatory events after vascularized composite allotransplantation (VCA) are critical to the success of immunomodulatory strategies of these complex procedures. To date, the effects of tacrolimus (TAC) immunosuppression on inflammatory networks in VCA, such as in acute rejection (AR), have not been investigated. We used a systems biology approach to elucidate the effects of tacrolimus on dynamic networks and principal drivers of systemic inflammation in the context of dynamic tissue-specific immune responses following VCA. Lewis (LEW) rat recipients received orthotopic hind limb VCA from fully major histocompatibility complex-mismatched Brown Norway (BN) donors or matched LEW donors. Group 1 (syngeneic controls) received LEW limbs without TAC, and Group 2 (treatment group) received BN limbs with TAC. Time-dependent changes in 27 inflammatory mediators were analyzed in skin, muscle, and peripheral blood using Principal Component Analysis (PCA), Dynamic Bayesian Network (DyBN) inference, and Dynamic Network Analysis (DyNA) to define principal characteristics, central nodes, and putative feedback structures of systemic inflammation. Analyses were repeated on skin + muscle data to construct a “Virtual VCA”, and in skin + muscle + peripheral blood data to construct a “Virtual Animal.” PCA, DyBN, and DyNA results from individual tissues suggested important roles for leptin, VEGF, various chemokines, the NLRP3 inflammasome (IL-1β, IL-18), and IL-6 after TAC treatment. The chemokines MCP-1, MIP-1α; and IP-10 were associated with AR in controls. Statistical analysis suggested that 24/27 inflammatory mediators were altered significantly between control and TAC-treated rats in peripheral blood, skin, and/or muscle over time. “Virtual VCA” and “Virtual Animal” analyses implicated the skin as a key control point of dynamic inflammatory networks, whose connectivity/complexity over time exhibited a U-shaped trajectory and was mirrored in the systemic circulation. Our study defines the effects of TAC on complex spatiotemporal evolution of dynamic inflammation networks in VCA. We also demonstrate the potential utility of computational analyses to elucidate nonlinear, cross-tissue interactions. These approaches may help define precision medicine approaches to better personalize TAC immunosuppression in VCA recipients.

Author response for "Overexpression of GILZ in macrophages limits systemic inflammation while increasing bacterial clearance in sepsis in mice"

2019 ◽  
Author(s):  
Mehdi Ellouze ◽  
Lola Vigouroux ◽  
Colas Tcherakian ◽  
Paul‐Louis Woerther ◽  
Aurélie Guguin ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Author Response ◽  
Bacterial Clearance

Expression of sunflower cytochrome c mRNA is tissue-specific and controlled by nitrate and light

1997 ◽  
Vol 99 (2) ◽  
pp. 342-347 ◽  
Author(s):  
Silvina A. Felitti ◽  
Raquel L. Chan ◽  
Gabriela Gago ◽  
Estela M. Valle ◽  
Daniel H. Gonzalez
Keyword(s):  
Cytochrome C ◽  
Tissue Specific
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