scholarly journals Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis

2018 ◽  
Vol 131 (14) ◽  
pp. jcs212977 ◽  
Author(s):  
Francesca Pala ◽  
Daniela Di Girolamo ◽  
Sébastien Mella ◽  
Siham Yennek ◽  
Laurent Chatre ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Cell Fates ◽  
Muscle Stem Cell ◽  
Metabolic States ◽  
Postnatal Myogenesis

scholarly journals PDH‐mediated metabolic flow is critical for skeletal muscle stem cell differentiation and myotube formation during regeneration in mice

2019 ◽  
Vol 33 (7) ◽  
pp. 8094-8109 ◽  
Author(s):  
Shimpei Hori ◽  
Yosuke Hiramuki ◽  
Daigo Nishimura ◽  
Fuminori Sato ◽  
Atsuko Sehara-Fujisawa
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Muscle Stem Cell ◽  
Myotube Formation

scholarly journals The p38 MAPK family, a pushmi-pullyu of skeletal muscle differentiation

2009 ◽  
Vol 187 (7) ◽  
pp. 941-943 ◽  
Author(s):  
Andrew B. Lassar
Keyword(s):  
Skeletal Muscle ◽  
Transcription Factor ◽  
Stem Cell ◽  
Muscle Differentiation ◽  
Mitogen Activated Protein Kinase ◽  
Stem Cell Population ◽  
Skeletal Muscle Differentiation ◽  
Gene Encoding ◽  
Muscle Stem Cell ◽  
Mitogen Activated Protein

In this issue, Gillespie et al. (Gillespie et al. 2009. J. Cell Biol. doi:10.1083/jcb.200907037) demonstrate that the mitogen-activated protein kinase isoform p38-γ plays a crucial role in blocking the premature differentiation of satellite cells, a skeletal muscle stem cell population. p38-γ puts the brakes on skeletal muscle differentiation by promoting the association of the transcription factor MyoD with the histone methyltransferase, KMT1A, which act together in a complex to repress the premature expression of the gene encoding the myogenic transcription factor Myogenin.

Tu1941 Inflammatory Bowel Disease Is Associated With Impaired Skeletal Muscle Stem Cell Regenerative Function

2013 ◽  
Vol 144 (5) ◽  
pp. S-886
Author(s):  
Johanna G. Palmadottir ◽  
Francisco A. Sylvester ◽  
Morgan E. Carlson ◽  
Andrew Draghi
Keyword(s):  
Skeletal Muscle ◽  
Inflammatory Bowel Disease ◽  
Stem Cell ◽  
Bowel Disease ◽  
Muscle Stem Cell ◽  
Inflammatory Bowel

scholarly journals Telocytes within human skeletal muscle stem cell niche

2011 ◽  
Vol 15 (10) ◽  
pp. 2269-2272 ◽  
Author(s):  
Florina M. Bojin ◽  
Oana I. Gavriliuc ◽  
Mirabela I. Cristea ◽  
Gabriela Tanasie ◽  
Carmen S. Tatu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Human Skeletal Muscle ◽  
Muscle Stem Cell ◽  
Cell Niche

scholarly journals Skeletal muscle stem cell self-renewal and differentiation kinetics revealed by EdU lineage tracing during regeneration

2019 ◽  
Author(s):  
Bradley Pawlikowski ◽  
Nicole Dalla Betta ◽  
Tiffany Antwine ◽  
Bradley B. Olwin
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Young Adult ◽  
Muscle Injury ◽  
Lineage Tracing ◽  
Stem Cell Population ◽  
Post Injury ◽  
Self Renewal ◽  
Muscle Stem Cell

SummarySkeletal muscle maintenance and repair is dependent on the resident adult muscle stem cell (MuSC). During injury, and in diseased muscle, stem cells are engaged to replace or repair damaged muscle, which requires the stem cells to exit quiescence and expand, followed by differentiation to regenerate myofibers and self-renewal to replenish the stem cell population. Following an injury, little is known regarding the timing of MuSC (skeletal muscle stem cell) self-renewal, myoblast expansion or myoblast differentiation. To determine the timing and kinetics of these cell fate decisions, we employed DNA-based lineage tracing to label newly replicated cells and followed cell fates during skeletal muscle regeneration. MuSCs activate and expand as myoblasts rapidly following injury, where the majority differentiate into myonuclei, establishing the centrally located myonuclear pool. Re-establishing the majority MuSC pool by self-renewal occurs after 5 days post-muscle injury, accompanied by low levels of myonuclear accretion that generate only peripheral myonuclei. In aged mice, possessing ∼1/2 the number of MuSCs present in young adult mice, the timing of post injury MuSC self-renewal is delayed, and although MuSCs expansion as myoblasts in aged muscle is impaired, the number of MuSC unexpectedly recovers to young adult levels during regeneration. Following an induced muscle injury, we found that myonuclei are generated within the first four days post injury derived from myoblasts expanding from activated MuSCs. Only later during regeneration, from 5 d to 14 d post injury, is the MuSC pool replenished by self-renewal, accompanied by generation of peripheral myonuclei.

scholarly journals Visualization of the Skeletal Muscle Stem Cell Niche in Fiber Bundles

2021 ◽  
Vol 1 (10) ◽  
Author(s):  
Svenja C. Schüler ◽  
Simon Dumontier ◽  
Jonathan Rigaux ◽  
C. Florian Bentzinger
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Fiber Bundles ◽  
Muscle Stem Cell ◽  
Cell Niche

scholarly journals Molecular Regulation and Rejuvenation of Muscle Stem (Satellite) Cell Aging

2015 ◽  
Vol 7 (2) ◽  
pp. 73
Author(s):  
Anna Meiliana ◽  
Nurrani Mustika Dewi ◽  
Andi Wijaya
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Satellite Cell ◽  
Muscle Mass ◽  
Satellite Cells ◽  
Cell Function ◽  
Muscle Stem Cell ◽  
Muscle Aging ◽  
Age Related

BACKGROUND: Age-related muscle loss leads to lack of muscle strength, resulting in reduced posture and mobility and an increased risk of falls, all of which contribute to a decrease in quality of life. Skeletal muscle regeneration is a complex process, which is not yet completely understood.CONTENT: Skeletal muscle undergoes a progressive age-related loss in mass and function. Preservation of muscle mass depends in part on satellite cells, the resident stem cells of skeletal muscle. Reduced satellite cell function may contribute to the age-associated decrease in muscle mass. Recent studies have delineated that the aging process in organ stem cells is largely caused by age-specific changes in the differentiated niches, and that regenerative outcomes often depend on the age of the niche, rather than on stem cell age. It is likely that epigenetic states will be better define such key satellite cell features as prolonged quiescence and lineage fidelity. It is also likely that DNA and histone modifications will underlie many of the changes in aged satellite cells that account for age-related declines in functionality and rejuvenation through exposure to the systemic environment.SUMMARY: Skeletal muscle aging results in a gradual loss of skeletal muscle mass, skeletal muscle function and regenerative capacity, which can lead to sarcopenia and increased mortality. Although the mechanisms underlying sarcopenia remain unclear, the skeletal muscle stem cell, or satellite cell, is required for muscle regeneration. Decreased muscle stem cell function in aging has long been shown to depend on altered environmental cues, whereas the contribution of intrinsic mechanisms remained less clear. Signals in the aged niche were shown to cause permanent defects in the ability of satellite cells to return to quiescence, ultimately also impairing the maintenance of self-renewing satellite cells. Therefore, only anti-aging strategies taking both factors, the stem cell niche and the stem cells per se, into consideration may ultimately be successful.KEYWORDS: satellite cell, muscle, aging, niche, regenerations

scholarly journals Multiscale 3D Genome Reorganization during Skeletal Muscle Stem Cell Lineage Progression and Muscle Aging

2021 ◽  
Author(s):  
Huating WANG ◽  
Yu Zhao ◽  
Yingzhe Ding ◽  
Liangqiang He ◽  
Yuying Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Differentiation ◽  
Regulatory Elements ◽  
Specific Gene ◽  
Muscle Stem Cell ◽  
3D Genome ◽  
Chromatin Looping ◽  
Early Activation

Abstract 3D genome rewiring is known to influence spatiotemporal expression of lineage-specific genes and cell fate transition during stem cell differentiation and aging processes. Yet it is unknown how 3D architecture remodels and orchestrates transcriptional changes during skeletal muscle stem cell (also called satellite cell, SC) activation, proliferation and differentiation course. Here, using in situ Hi-C we comprehensively map the 3D genome topology reorganization at multiscale levels during mouse SC lineage progression and integrate with transcriptional and chromatin signatures to elucidate how 3D genome rewiring dictates gene expression program. Specifically, rewiring at compartment level is most pronounced when SC becomes activated. Striking loss in TAD border insulation and chromatin looping also occurs during early activation process. Meanwhile, TADs can also form TAD clusters and super-enhancer containing TAD clusters orchestrate stage-specific gene expression during SC early activation. Furthermore, we elucidate 3D chromatin regulation of key transcription factor, PAX7 and identify cis-regulatory elements that are crucial for local chromatin architecture and Pax7 expression. Lastly, 3D genome remodeling is profiled in SCs isolated from naturally aging mice, unveiling that geriatric SCs display a prominent gain in long-range contacts and loss of TAD border insulation. Genome compartmentalization and chromatin looping are evidently altered in aged SC while geriatric SC display a more prominent loss in strength of TAD borders. Together, our results implicate 3D chromatin extensively reorganizes at multiple architectural levels and underpin the transcriptome remodeling during SC lineage development and SC aging.

Muscle Stem Cell Depletion Blunts Skeletal Muscle Adaptation to Weighted Wheel Running

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Alec Marc Dupont ◽  
Davis Englund ◽  
John McCarthy ◽  
Charlotte Peterson
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Wheel Running ◽  
Cell Depletion ◽  
Muscle Adaptation ◽  
Muscle Stem Cell

scholarly journals Single-Cell Analysis of the Muscle Stem Cell Hierarchy Identifies Heterotypic Communication Signals Involved in Skeletal Muscle Regeneration

Cell Reports ◽  
2020 ◽  
Vol 30 (10) ◽  
pp. 3583-3595.e5 ◽  
Author(s):  
Andrea J. De Micheli ◽  
Emily J. Laurilliard ◽  
Charles L. Heinke ◽  
Hiranmayi Ravichandran ◽  
Paula Fraczek ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Single Cell ◽  
Muscle Regeneration ◽  
Single Cell Analysis ◽  
Skeletal Muscle Regeneration ◽  
Cell Analysis ◽  
Muscle Stem Cell ◽  
Communication Signals ◽  
Stem Cell Hierarchy
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