Thyroid follicle development requires Smad1/Smad5- and endothelial-dependent basement membrane assembly

2016 ◽  
Vol 129 (12) ◽  
pp. e1.1-e1.1
Author(s):  
Mylah Villacorte ◽  
Anne-Sophie Delmarcelle ◽  
Manon Lernoux ◽  
Mahé Bouquet ◽  
Pascale Lemoine ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Follicle Development ◽  
Thyroid Follicle ◽  
Membrane Assembly

scholarly journals Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly

Development ◽  
2016 ◽  
Vol 143 (11) ◽  
pp. 1958-1970 ◽  
Author(s):  
Mylah Villacorte ◽  
Anne-Sophie Delmarcelle ◽  
Manon Lernoux ◽  
Mahé Bouquet ◽  
Pascale Lemoine ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Basement Membrane ◽  
Follicle Development ◽  
Thyroid Follicle ◽  
Membrane Assembly

scholarly journals Sonic hedgehog-dependent synthesis of laminin  1 controls basement membrane assembly in the myotome

Development ◽  
2009 ◽  
Vol 136 (20) ◽  
pp. 3495-3504 ◽  
Author(s):  
C. Anderson ◽  
S. Thorsteinsdottir ◽  
A.-G. Borycki
Keyword(s):  
Basement Membrane ◽  
Sonic Hedgehog ◽  
Membrane Assembly ◽  
Laminin 1

Basement membrane assembly, stability and activities observed through a developmental lens

2004 ◽  
Vol 22 (7) ◽  
pp. 521-538 ◽  
Author(s):  
Peter D. Yurchenco ◽  
Peter S. Amenta ◽  
Bruce L. Patton
Keyword(s):  
Basement Membrane ◽  
Membrane Assembly

scholarly journals Role of Laminin Terminal Globular Domains in Basement Membrane Assembly

2007 ◽  
Vol 282 (29) ◽  
pp. 21437-21447 ◽  
Author(s):  
Karen K. McKee ◽  
David Harrison ◽  
Stephanie Capizzi ◽  
Peter D. Yurchenco
Keyword(s):  
Basement Membrane ◽  
Membrane Assembly

scholarly journals Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation

2002 ◽  
Vol 157 (7) ◽  
pp. 1279-1290 ◽  
Author(s):  
Shaohua Li ◽  
David Harrison ◽  
Salvatore Carbonetto ◽  
Reinhard Fässler ◽  
Neil Smyth ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Cell Mass ◽  
Embryonic Stem ◽  
Stem Cell Differentiation ◽  
Embryoid Bodies ◽  
Embryonic Stem Cell Differentiation ◽  
Companion Matrix ◽  
Β1 Integrin ◽  
Matrix Assembly ◽  
Membrane Assembly

Laminin-1 is essential for early embryonic basement membrane assembly and differentiation. Several steps can be distinguished, i.e., the expression of laminin and companion matrix components, their accumulation on the cell surface and assembly into basement membrane between endoderm and inner cell mass, and the ensuing differentiation of epiblast. In this study, we used differentiating embryoid bodies derived from mouse embryonic stem cells null for γ1-laminin, β1-integrin and α/β-dystroglycan to dissect the contributions of laminin domains and interacting receptors to this process. We found that (a) laminin enables β1-integrin–null embryoid bodies to assemble basement membrane and achieve epiblast with β1-integrin enabling expression of the laminin α1 subunit; (b) basement membrane assembly and differentiation require laminin polymerization in conjunction with cell anchorage, the latter critically dependent upon a heparin-binding locus within LG module-4; (c) dystroglycan is not uniquely required for basement membrane assembly or initial differentiation; (d) dystroglycan and integrin cooperate to sustain survival of the epiblast and regulate laminin expression; and (e) laminin, acting via β1-integrin through LG1–3 and requiring polymerization, can regulate dystroglycan expression.

Basement Membrane Assembly and Differentiation of Cultured Corneal Cells: Importance of Culture Environment and Endothelial Cell Interaction

1994 ◽  
Vol 214 (2) ◽  
pp. 621-633 ◽  
Author(s):  
James D. Zieske ◽  
Valerie S. Mason ◽  
Michael E. Wasson ◽  
Susan F. Meunier ◽  
Cynthia J.M. Nolte ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Basement Membrane ◽  
Cell Interaction ◽  
Membrane Assembly ◽  
Endothelial Cell Interaction ◽  
Culture Environment ◽  
Corneal Cells

scholarly journals An active role for basement membrane assembly and modification in tissue sculpting

2015 ◽  
Vol 128 (9) ◽  
pp. 1661-1668 ◽  
Author(s):  
M. A. Morrissey ◽  
D. R. Sherwood
Keyword(s):  
Basement Membrane ◽  
Active Role ◽  
Membrane Assembly

scholarly journals Inhibition of laminin alpha 1-chain expression leads to alteration of basement membrane assembly and cell differentiation.

1996 ◽  
Vol 133 (2) ◽  
pp. 417-430 ◽  
Author(s):  
A De Arcangelis ◽  
P Neuville ◽  
R Boukamel ◽  
O Lefebvre ◽  
M Kedinger ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Basement Membrane ◽  
Regulatory Element ◽  
Digestive Enzyme ◽  
Eukaryotic Expression ◽  
Basement Membranes ◽  
Chain Gene ◽  
Membrane Assembly ◽  
Development And Differentiation ◽  
Laminin 1

The expression of the constituent alpha 1 chain of laminin-1, a major component of basement membranes, is markedly regulated during development and differentiation. We have designed an antisense RNA strategy to analyze the direct involvement of the alpha 1 chain in laminin assembly, basement membrane formation, and cell differentiation. We report that the absence of alpha 1-chain expression, resulting from the stable transfection of the human colonic cancer Caco2 cells with an eukaryotic expression vector comprising a cDNA fragment of the alpha 1 chain inserted in an antisense orientation, led to (a) an incorrect secretion of the two other constituent chains of laminin-1, the beta 1/gamma 1 chains, (b) the lack of basement membrane assembly when Caco2-deficient cells were cultured on top of fibroblasts, assessed by the absence of collagen IV and nidogen deposition, and (c) changes in the structural polarity of cells accompanied by the inhibition of an apical digestive enzyme, sucrase-isomaltase. The results demonstrate that the alpha 1 chain is required for secretion of laminin-1 and for the assembly of basement membrane network. Furthermore, expression of the laminin alpha 1-chain gene may be a regulatory element in determining cell differentiation.

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