scholarly journals Protein kinase A regulation of T-type Ca2+ channels in rat cerebral arterial smooth muscle

2013 ◽  
Vol 126 (13) ◽  
pp. 2944-2954 ◽  
Author(s):  
O. F. Harraz ◽  
D. G. Welsh
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Arterial Smooth Muscle ◽  
Ca2 Channels ◽  
Kinase A

scholarly journals β-Agonist-mediated Relaxation of Airway Smooth Muscle Is Protein Kinase A-dependent

2014 ◽  
Vol 289 (33) ◽  
pp. 23065-23074 ◽  
Author(s):  
Sarah J. Morgan ◽  
Deepak A. Deshpande ◽  
Brian C. Tiegs ◽  
Anna M. Misior ◽  
Huandong Yan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Airway Smooth Muscle ◽  
Kinase A

Protein kinase A mediates activation of ATP-sensitive K+ currents by CGRP in gallbladder smooth muscle

1994 ◽  
Vol 267 (3) ◽  
pp. G494-G499 ◽  
Author(s):  
L. Zhang ◽  
A. D. Bonev ◽  
G. M. Mawe ◽  
M. T. Nelson
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Whole Cell Patch Clamp ◽  
Camp Analogue ◽  
Calcitonin Gene ◽  
Transduction Mechanisms ◽  
Spontaneous Action ◽  
Spontaneous Action Potentials ◽  
Kinase A

The signal transduction mechanisms underlying the activation of ATP-sensitive potassium (KATP) current by calcitonin gene-related peptide (CGRP) in gallbladder smooth muscle were examined with intracellular microelectrode recording and whole cell patch-clamp techniques. In the intact gallbladder preparation, the adenylyl cyclase activator forskolin hyperpolarized the membrane potential and abolished spontaneous action potentials. This response was inhibited by the KATP channel blocker glibenclamide. CGRP (10 nM), forskolin (10 microM), the membrane-permeable adenosine 3',5'-cyclic monophosphate (cAMP) analogue adenosine 3',5'-cyclic monophosphothioate (Sp-cAMP[S]; 500 microM), and the catalytic subunit of protein kinase A (100 U/ml) activated glibenclamide-sensitive currents in enzymatically dissociated gallbladder smooth muscle cells. CGRP activation of potassium currents was prevented by dialysis of the cell cytoplasm with guanosine 5'-O-(2-thiodiphosphate) (5 mM) or a specific peptide inhibitor of protein kinase A (2.3 microM). Okadaic acid (5 microM), a phosphatase inhibitor, slowed the deactivation of the KATP current, following removal of CGRP. The results of this study indicate that CGRP hyperpolarizes gallbladder smooth muscle by elevation of cAMP and subsequent stimulation of protein kinase A.

Antimitogenic Effects of Trapidil In Coronary Artery Smooth Muscle Cells by Direct Activation of Protein Kinase A

1998 ◽  
Vol 54 (2) ◽  
pp. 241-248 ◽  
Author(s):  
Detlef Bönisch ◽  
Artur-Aron Weber ◽  
Michael Wittpoth ◽  
Michael Osinski ◽  
Karsten Schrör
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Protein Kinase ◽  
Smooth Muscle Cells ◽  
Protein Kinase A ◽  
Muscle Cells ◽  
Direct Activation ◽  
Kinase A
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