scholarly journals Glutathione peroxidase 3, a new retinoid target gene, is crucial for human skeletal muscle precursor cell survival

2012 ◽  
Vol 125 (24) ◽  
pp. 6147-6156 ◽  
Author(s):  
M. El Haddad ◽  
E. Jean ◽  
A. Turki ◽  
G. Hugon ◽  
B. Vernus ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Glutathione Peroxidase ◽  
Cell Survival ◽  
Human Skeletal Muscle ◽  
Target Gene ◽  
Precursor Cell ◽  
Muscle Precursor ◽  
Glutathione Peroxidase 3 ◽  
Muscle Precursor Cell

Optimization of human skeletal muscle precursor cell culture and myofiber formation in vitro

Methods ◽  
2009 ◽  
Vol 47 (2) ◽  
pp. 98-103 ◽  
Author(s):  
Daniel Eberli ◽  
Shay Soker ◽  
Anthony Atala ◽  
James J. Yoo
Keyword(s):  
Skeletal Muscle ◽  
Cell Culture ◽  
Human Skeletal Muscle ◽  
Precursor Cell ◽  
Muscle Precursor ◽  
Muscle Precursor Cell

scholarly journals Age-related impairment of T cell-induced skeletal muscle precursor cell function

2011 ◽  
Vol 300 (6) ◽  
pp. C1226-C1233 ◽  
Author(s):  
Breanna R. Dumke ◽  
Simon J. Lees
Keyword(s):  
Skeletal Muscle ◽  
T Cells ◽  
T Cell ◽  
Cell Function ◽  
Critical Role ◽  
Interleukin 2 ◽  
Precursor Cell ◽  
Muscle Precursor ◽  
Age Related ◽  
Muscle Precursor Cell

Sarcopenia is the age-associated loss of skeletal muscle mass and strength. Recent evidence suggests that an age-associated loss of muscle precursor cell (MPC) functionality contributes to sarcopenia. The objectives of the present study were to examine the influence of activated T cells on MPCs and determine whether an age-related defect in this signaling occurs. MPCs were collected from the gastrocnemius and plantaris of 3-mo-old (young) and 32-mo-old (old) animals. Splenic T cells were harvested using anti-CD3 Dynabead isolation. T cells were activated for 48 h with costimulation of 100 IU/ml interleukin-2 (IL-2) and 5 μg/ml of anti-CD28. Costimulation increased 5-bromo-2′-deoxyuridine incorporation of T cells from 13.4 ± 4.6% in control to 64.8 ± 6.0% in costimulated cells. Additionally, T cell cytokines increased proliferation on MPCs isolated from young muscle by 24.0 ± 5.7%, whereas there was no effect on MPCs isolated from aged muscle. T cell cytokines were also found to be a chemoattractant. T cells were able to promote migration of MPCs isolated from young muscle; however, MPCs isolated from aged muscle did not respond to the T cell-released chemokines. Conversely, whereas T cell-released cytokines did not affect myogenesis of MPCs isolated from young animals, there was a decrease in MPCs isolated from old animals. These data suggest that T cells may play a critical role in mediating MPC function. Furthermore, aging may alter T cell-induced MPC function. These findings have implications for developing strategies aimed at increasing MPC migration and proliferation leading to an improved regenerative capacity of aged skeletal muscle.

scholarly journals The Dose-Effect Safety Profile of Skeletal Muscle Precursor Cell Therapy in a Dog Model of Intrinsic Urinary Sphincter Deficiency

2015 ◽  
Vol 4 (3) ◽  
pp. 286-294 ◽  
Author(s):  
J. Koudy Williams ◽  
Delrae Eckman ◽  
Ashley Dean ◽  
Mahmoudreza Moradi ◽  
Julie Allickson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Therapy ◽  
Safety Profile ◽  
Precursor Cell ◽  
Dose Effect ◽  
Muscle Precursor ◽  
Dog Model ◽  
Urinary Sphincter ◽  
Muscle Precursor Cell ◽  
Sphincter Deficiency

scholarly journals Sirt1 increases skeletal muscle precursor cell proliferation

2009 ◽  
Vol 88 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Christopher R. Rathbone ◽  
Frank W. Booth ◽  
Simon J. Lees
Keyword(s):  
Skeletal Muscle ◽  
Cell Proliferation ◽  
Precursor Cell ◽  
Muscle Precursor ◽  
Muscle Precursor Cell

scholarly journals Increased myogenic precursor cell number in human skeletal muscle with 12 weeks of training at low intensity

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Abigail Louise Mackey ◽  
Lars Holm ◽  
Søren Reitelseder ◽  
Troels Gravers Pedersen ◽  
Fawzi Kadi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Cell Number ◽  
Precursor Cell ◽  
Low Intensity ◽  
Myogenic Precursor

m-Calpain implication in cell cycle during muscle precursor cell activation

2004 ◽  
Vol 298 (1) ◽  
pp. 48-57 ◽  
Author(s):  
F Raynaud ◽  
G Carnac ◽  
A Marcilhac ◽  
Y Benyamin
Keyword(s):  
Cell Cycle ◽  
Cell Activation ◽  
Precursor Cell ◽  
Muscle Precursor ◽  
Muscle Precursor Cell
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