scholarly journals Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes

2012 ◽  
Vol 125 (18) ◽  
pp. 4405-4412 ◽  
Author(s):  
A. Rossi ◽  
T. J. Moritz ◽  
J. Ratelade ◽  
A. S. Verkman
Keyword(s):  
Cell Membranes ◽  
Super Resolution ◽  
Orthogonal Arrays ◽  
Aquaporin 4 ◽  
Orthogonal Arrays Of Particles ◽  
Resolution Imaging

Super-resolution imaging of cancer-associated carbohydrates using aptamer probes

Nanoscale ◽  
2019 ◽  
Vol 11 (31) ◽  
pp. 14879-14886 ◽  
Author(s):  
Yingying Jing ◽  
Junling Chen ◽  
Lulu Zhou ◽  
Jiayin Sun ◽  
Mingjun Cai ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Membranes ◽  
Super Resolution ◽  
High Expression ◽  
Resolution Imaging ◽  
Potential Interactions

Relying on fluorophore-conjugated aptamers, we revealed the high expression and clustered distribution of globo H on cancer cell membranes and uncovered the potential interactions between cancer-associated carbohydrates via super-resolution imaging.

Structure and Functions of Aquaporin-4-Based Orthogonal Arrays of Particles

2011 ◽  
pp. 1-41 ◽  
Author(s):  
Hartwig Wolburg ◽  
Karen Wolburg-Buchholz ◽  
Petra Fallier-Becker ◽  
Susan Noell ◽  
Andreas F. Mack
Keyword(s):  
Orthogonal Arrays ◽  
Aquaporin 4 ◽  
Orthogonal Arrays Of Particles ◽  
Structure And Functions

scholarly journals Aquaporin-4 orthogonal arrays of particles from a physiological and pathophysiological point of view

2013 ◽  
Vol 2 (4) ◽  
pp. 143-154 ◽  
Author(s):  
Grazia Paola Nicchia ◽  
Francesco Pisani ◽  
Angelo Sparaneo ◽  
Maria Grazia Mola ◽  
Davide Basco ◽  
...  
Keyword(s):  
Orthogonal Arrays ◽  
Point Of View ◽  
Aquaporin 4 ◽  
Orthogonal Arrays Of Particles

scholarly journals Is Upregulation of Aquaporin 4-M1 Isoform Responsible for the Loss of Typical Orthogonal Arrays of Particles in Astrocytomas?

2016 ◽  
Vol 17 (8) ◽  
pp. 1230 ◽  
Author(s):  
Petra Fallier-Becker ◽  
Maike Nieser ◽  
Ulrike Wenzel ◽  
Rainer Ritz ◽  
Susan Noell
Keyword(s):  
Orthogonal Arrays ◽  
Aquaporin 4 ◽  
Orthogonal Arrays Of Particles

All functional aquaporin-4 isoforms are expressed in the rat cochlea and contribute to the formation of orthogonal arrays of particles

Neuroscience ◽  
2011 ◽  
Vol 189 ◽  
pp. 79-92 ◽  
Author(s):  
B. Hirt ◽  
C. Gleiser ◽  
A. Eckhard ◽  
A.F. Mack ◽  
M. Müller ◽  
...  
Keyword(s):  
Orthogonal Arrays ◽  
Aquaporin 4 ◽  
Rat Cochlea ◽  
Orthogonal Arrays Of Particles

scholarly journals Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging

2018 ◽  
Vol 115 (27) ◽  
pp. 7033-7038 ◽  
Author(s):  
Qiuyan Yan ◽  
Yanting Lu ◽  
Lulu Zhou ◽  
Junling Chen ◽  
Haijiao Xu ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Cell Membranes ◽  
Molecular Mechanisms ◽  
Glucose Transporter ◽  
Super Resolution ◽  
Average Diameter ◽  
Activation Mechanism ◽  
Membrane Expression ◽  
Close Relationship ◽  
Resolution Imaging

The glucose transporter GLUT1, a plasma membrane protein that mediates glucose homeostasis in mammalian cells, is responsible for constitutive uptake of glucose into many tissues and organs. Many studies have focused on its vital physiological functions and close relationship with diseases. However, the molecular mechanisms of its activation and transport are not clear, and its detailed distribution pattern on cell membranes also remains unknown. To address these, we first investigated the distribution and assembly of GLUT1 at a nanometer resolution by super-resolution imaging. On HeLa cell membranes, the transporter formed clusters with an average diameter of ∼250 nm, the majority of which were regulated by lipid rafts, as well as being restricted in size by both the cytoskeleton and glycosylation. More importantly, we found that the activation of GLUT1 by azide or MβCD did not increase its membrane expression but induced the decrease of the large clusters. The results suggested that sporadic distribution of GLUT1 may facilitate the transport of glucose, implying a potential association between the distribution and activation. Collectively, our work characterized the clustering distribution of GLUT1 and linked its spatial structural organization to the functions, which would provide insights into the activation mechanism of the transporter.

scholarly journals Mechanistic Insights into Trop2 Clustering on Lung Cancer Cell Membranes Revealed by Super-resolution Imaging

ACS Omega ◽  
2020 ◽  
Vol 5 (50) ◽  
pp. 32456-32465
Author(s):  
Yilin Fu ◽  
Peiyan Hua ◽  
Yan Lou ◽  
Zihao Li ◽  
Meng Jia ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Super Resolution ◽  
Lung Cancer Cell ◽  
Resolution Imaging
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