scholarly journals A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland

2011 ◽  
Vol 124 (20) ◽  
pp. 3503-3514 ◽  
Author(s):  
S. Xu ◽  
M. Edman ◽  
M. S. Kothawala ◽  
G. Sun ◽  
L. Chiang ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Lacrimal Gland ◽  
Membrane Compartment

Effect of sialodacryoadenitis virus exposure on acinar epithelial cells from the rat lacrimal gland

1997 ◽  
Vol 5 (3) ◽  
pp. 181-195 ◽  
Author(s):  
L. Alexandra Wickham ◽  
Zhiyan Huang ◽  
Ross W. Lambert ◽  
David A. Sullivan
Keyword(s):  
Epithelial Cells ◽  
Lacrimal Gland ◽  
Virus Exposure

scholarly journals Not All Lacrimal Epithelial Cells are Created Equal—Heterogeneity of the Rabbit Lacrimal Gland and Differential Secretion

2011 ◽  
Vol 36 (11) ◽  
pp. 971-978 ◽  
Author(s):  
Chuanqing Ding ◽  
Jianyan Huang ◽  
Michelle MacVeigh-Aloni ◽  
Michael Lu
Keyword(s):  
Epithelial Cells ◽  
Lacrimal Gland

scholarly journals Human myosin-Vc is a novel class V myosin expressed in epithelial cells

2002 ◽  
Vol 115 (5) ◽  
pp. 991-1004 ◽  
Author(s):  
Olga C. Rodriguez ◽  
Richard E. Cheney
Keyword(s):  
Epithelial Cells ◽  
Membrane Trafficking ◽  
Dominant Negative ◽  
Organelle Transport ◽  
Protein Distribution ◽  
Class V ◽  
Systematic Analysis ◽  
Neuronal Tissues ◽  
Membrane Compartment ◽  
Myosin Va

Class V myosins are one of the most ancient and widely distributed groups of the myosin superfamily and are hypothesized to function as motors for actin-dependent organelle transport. We report the discovery and initial characterization of a novel member of this family, human myosin-Vc (Myo5c). The Myo5c protein sequence shares ∼50% overall identity with the two other class V myosins in vertebrates, myosin-Va (Myo5a) and myosin-Vb (Myo5b). Systematic analysis of the mRNA and protein distribution of these myosins indicates that Myo5a is most abundant in brain, whereas Myo5b and Myo5c are expressed chiefly in non-neuronal tissues. Myo5c is particularly abundant in epithelial and glandular tissues including pancreas, prostate, mammary,stomach, colon and lung. Immunolocalization in colon and exocrine pancreas indicates that Myo5c is expressed chiefly in epithelial cells. A dominant negative approach using a GFP-Myo5c tail construct in HeLa cells reveals that the Myo5c tail selectively colocalizes with and perturbs a membrane compartment containing the transferrin receptor and rab8. Transferrin also accumulates in this compartment, suggesting that Myo5c is involved in transferrin trafficking. As a class V myosin of epithelial cells, Myo5c is likely to power actin-based membrane trafficking in many physiologically crucial tissues of the human body.

Functional presence of Na+-K+-2Cl- cotransporter in rabbit lacrimal gland ductal epithelial cells

2014 ◽  
Vol 92 ◽  
pp. 0-0
Author(s):  
E TÓTH-MOLNÁR ◽  
M KATONA ◽  
E VIZVARI ◽  
A FACSKO ◽  
V VENGLOVECZ ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Lacrimal Gland

Bidirectional transport of cholesterol between gallbladder epithelial cells and model bile

1996 ◽  
Vol 271 (3) ◽  
pp. G410-G414
Author(s):  
A. Hayashi ◽  
S. P. Lee
Keyword(s):  
Epithelial Cells ◽  
Bile Salts ◽  
Apical Membrane ◽  
Cholesterol Absorption ◽  
Gallbladder Epithelium ◽  
Physicochemical Composition ◽  
Membrane Compartment ◽  
Bidirectional Transport ◽  
Model Bile ◽  
Bidirectional Exchange

Lipids in hepatic bile may be modified by the gallbladder epithelium. The purpose of this study was to demonstrate a bidirectional exchange of cholesterol between biliary lipid carriers and gallbladder epithelial cells and to determine the factors regulating this cholesterol transfer. Gallbladder epithelial cells were cultured to confluent monolayers, their membranes were labeled with endogenously synthesized [14C]cholesterol, and the cells were incubated with model bile introduced into the apical membrane compartment. Similarly, model bile with different lipid composition containing [3H]cholesterol was incubated with the unlabeled monolayers. We found that cholesterol in the apical membrane bilayer of the epithelial cells exchanged readily with that in bile, but only in the presence of bile salts. The rate of exchange is dependent on the concentration and species of bile salts. The net gain of cholesterol (absorption) or net loss of cholesterol (cytotoxicity) exhibited by the epithelial cells was regulated by the thermodynamic stability of cholesterol and the detergent effect of mixed micelles in bile. It is also possible that the physicochemical composition of lipids in bile may modify the cellular function of the gallbladder epithelium.

Lacrimal Gland Epithelial Cells Stimulate Proliferation in Autologous Lymphocyte Preparations

2000 ◽  
Vol 71 (1) ◽  
pp. 11-22 ◽  
Author(s):  
Zhijun Guo ◽  
Ana Maria Azzarolo ◽  
Joel E Schechter ◽  
Dwight W Warren ◽  
Richard L Wood ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Lacrimal Gland ◽  
Autologous Lymphocyte

Expression of IL-10 and TNF-Inhibitor Genes in Lacrimal Gland Epithelial Cells Suppresses Their Ability to Activate Lymphocytes

Cornea ◽  
2002 ◽  
Vol 21 (2) ◽  
pp. 210-214 ◽  
Author(s):  
Zejin Zhu ◽  
Douglas Stevenson ◽  
Thomas Ritter ◽  
Joel E. Schechter ◽  
Austin K. Mircheff ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Lacrimal Gland ◽  
Tnf Inhibitor ◽  
Inhibitor Genes

Characterization of immortalized rabbit lacrimal gland epithelial cells

1999 ◽  
Vol 35 (4) ◽  
pp. 198-204 ◽  
Author(s):  
Doan H. Nguyen ◽  
Roger W. Beuerman ◽  
Christine L. Halbert ◽  
Qiangwei MA ◽  
Guang Sun
Keyword(s):  
Epithelial Cells ◽  
Lacrimal Gland

scholarly journals Lacrimal gland adenoma in a sheep

2019 ◽  
Vol 22 (1) ◽  
pp. 122-126
Author(s):  
G. Farjanikish ◽  
A. Khodakaram-Tafti ◽  
M. Ghane
Keyword(s):  
Epithelial Cells ◽  
Lacrimal Gland ◽  
Corneal Edema ◽  
Cell Types ◽  
Myoepithelial Cells ◽  
Tubular Structures ◽  
Mitotic Figures ◽  
Veterinary Hospital ◽  
Cellular Pleomorphism ◽  
Luminal Epithelial Cells

The lacrimal gland is a diamond-shaped, tubuloalveolar gland that secretes the serous component of tears. A four-year-old female crossbreed sheep suffering from left eye protrusion was referred to a Veterinary Hospital. Ophthalmic examination revealed epiphora, superficial ulcerative keratitis, corneal edema and neovascularisation. Moreover, ultrasound examination showed a large heterogeneous mass with variable reflectivity in the intraconal and extraconal spaces. Grossly, a 2.5×1.5×0.5 cm oval firm grayish mass was observed. Histopathologically, the mass was composed mainly by tubules with two cell types including cuboidal luminal epithelial cells and peripheral myoepithelial cells. The tubular structures were separated by proliferating myoepithelial cells. Mitotic figures, cellular pleomorphism and atypia were not seen. Immunohistochemically, most of the luminal epithelial cells showed an immunopositive reaction with a cytokeratin (AE1/AE3) marker. On the basis of these findings, the mass was diagnosed as a lacrimal gland adenoma.

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