scholarly journals Von Hippel-Lindau gene product directs cytokinesis: a new tumor suppressor function

2011 ◽  
Vol 124 (13) ◽  
pp. 2132-2142 ◽  
Author(s):  
S. Sinha ◽  
G. Mondal ◽  
E. J. Hwang ◽  
D. W. Han ◽  
S. K. Dutta ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Gene Product ◽  
Tumor Suppressor Function ◽  
Von Hippel Lindau ◽  
Suppressor Function

scholarly journals Tumor Suppression by the von Hippel-Lindau Protein Requires Phosphorylation of the Acidic Domain

2005 ◽  
Vol 280 (23) ◽  
pp. 22205-22211 ◽  
Author(s):  
Martijn P. Lolkema ◽  
Michelle L. Gervais ◽  
Cristel M. Snijckers ◽  
Richard P. Hill ◽  
Rachel H. Giles ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppression ◽  
Hypoxia Inducible Factor ◽  
Tumor Formation ◽  
Tumor Suppressor Function ◽  
Von Hippel Lindau ◽  
Matrix Deposition ◽  
Acidic Domain ◽  
Suppressor Function ◽  
Fibronectin Matrix

The tumor suppressor function of the von Hippel-Lindau protein (pVHL) has previously been linked to its role in regulating hypoxia-inducible factor levels. However, VHL gene mutations suggest a hypoxia-inducible factor-independent function for the N-terminal acidic domain in tumor suppression. Here, we report that phosphorylation of the N-terminal acidic domain of pVHL by casein kinase-2 is essential for its tumor suppressor function. This post-translational modification did not affect the levels of hypoxia-inducible factor; however, it did change the binding of pVHL to another known binding partner, fibronectin. Cells expressing phospho-defective mutants caused improper fibronectin matrix deposition and demonstrated retarded tumor formation in mice. We propose that phosphorylation of the acidic domain plays a role in the regulation of proper fibronectin matrix deposition and that this may be relevant for the development of VHL-associated malignancies.

Differential MicroRNA-34a Expression and Tumor Suppressor Function in Retinoblastoma Cells

2009 ◽  
Vol 50 (10) ◽  
pp. 4542 ◽  
Author(s):  
Clifton L. Dalgard ◽  
Marco Gonzalez ◽  
Jennifer E. deNiro ◽  
Joan M. O'Brien
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Function ◽  
Suppressor Function ◽  
Retinoblastoma Cells

scholarly journals Transcriptome analysis of pancreatic cancer reveals a tumor suppressor function for HNF1A

2014 ◽  
Vol 35 (12) ◽  
pp. 2670-2678 ◽  
Author(s):  
Jason W. Hoskins ◽  
Jinping Jia ◽  
Marta Flandez ◽  
Hemang Parikh ◽  
Wenming Xiao ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Suppressor ◽  
Transcriptome Analysis ◽  
Tumor Suppressor Function ◽  
Suppressor Function

OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer

2003 ◽  
Vol 34 (3) ◽  
pp. 337-343 ◽  
Author(s):  
Grant C Sellar ◽  
Karen P Watt ◽  
Genevieve J Rabiasz ◽  
Euan A Stronach ◽  
Li Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Suppressor ◽  
Epithelial Ovarian Cancer ◽  
Tumor Suppressor Function ◽  
Suppressor Function
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