Differential MicroRNA-34a Expression and Tumor Suppressor Function in Retinoblastoma Cells

2009 ◽  
Vol 50 (10) ◽  
pp. 4542 ◽  
Author(s):  
Clifton L. Dalgard ◽  
Marco Gonzalez ◽  
Jennifer E. deNiro ◽  
Joan M. O'Brien
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Function ◽  
Suppressor Function ◽  
Retinoblastoma Cells

scholarly journals Transcriptome analysis of pancreatic cancer reveals a tumor suppressor function for HNF1A

2014 ◽  
Vol 35 (12) ◽  
pp. 2670-2678 ◽  
Author(s):  
Jason W. Hoskins ◽  
Jinping Jia ◽  
Marta Flandez ◽  
Hemang Parikh ◽  
Wenming Xiao ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Suppressor ◽  
Transcriptome Analysis ◽  
Tumor Suppressor Function ◽  
Suppressor Function

OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer

2003 ◽  
Vol 34 (3) ◽  
pp. 337-343 ◽  
Author(s):  
Grant C Sellar ◽  
Karen P Watt ◽  
Genevieve J Rabiasz ◽  
Euan A Stronach ◽  
Li Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Suppressor ◽  
Epithelial Ovarian Cancer ◽  
Tumor Suppressor Function ◽  
Suppressor Function

scholarly journals A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes

Cancer Cell ◽  
2015 ◽  
Vol 28 (6) ◽  
pp. 730-742 ◽  
Author(s):  
Claudio Giachino ◽  
Jean-Louis Boulay ◽  
Robert Ivanek ◽  
Alvaro Alvarado ◽  
Cristobal Tostado ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Notch Signaling ◽  
Tumor Suppressor Function ◽  
Tumor Subtypes ◽  
Suppressor Function

scholarly journals Tumor Suppressor Function of miR-127-3p and miR-376a-3p in Osteosarcoma Cells

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2019 ◽  
Author(s):  
Joerg Fellenberg ◽  
Burkhard Lehner ◽  
Heiner Saehr ◽  
Astrid Schenker ◽  
Pierre Kunz
Keyword(s):  
Tumor Suppressor ◽  
Therapeutic Strategies ◽  
High Dose ◽  
Osteosarcoma Cell ◽  
Tumor Suppressor Function ◽  
Osteosarcoma Cells ◽  
Aberrant Expression ◽  
Suppressor Function

Since the introduction of high-dose chemotherapy about 35 years ago, survival rates of osteosarcoma patients have not been significantly improved. New therapeutic strategies replacing or complementing conventional chemotherapy are therefore urgently required. MicroRNAs represent promising targets for such new therapies, as they are involved in the pathology of multiple types of cancer, and aberrant expression of several miRNAs has already been shown in osteosarcoma. In this study, we identified silencing of miR-127-3p and miR-376a-3p in osteosarcoma cell lines and tissues and investigated their role as potential tumor suppressors in vitro and in vivo. Transfection of osteosarcoma cells (n = 6) with miR-127-3p and miR-376a-3p mimics significantly inhibited proliferation and reduced the colony formation capacity of these cells. In contrast, we could not detect any influence of miRNA restoration on cell cycle and apoptosis induction. The effects of candidate miRNA restoration on tumor engraftment and growth in vivo were analyzed using a chicken chorioallantoic membrane (CAM) assay. Cells transfected with mir-127-3p and miR-376a-3p showed reduced tumor take rates and tumor volumes and a significant decrease of the cumulative tumor volumes to 41% and 54% compared to wildtype cells. The observed tumor suppressor function of both analyzed miRNAs indicates these miRNAs as potentially valuable targets for the development of new therapeutic strategies for the treatment of osteosarcoma.

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