scholarly journals Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism

2005 ◽  
Vol 118 (12) ◽  
pp. 2557-2566 ◽  
Author(s):  
J. C. R. Jones
Keyword(s):  
Signal Transduction ◽  
Mechanical Signal ◽  
Independent Mechanism

Mechanical signal transduction in skeletal muscle growth and adaptation

2005 ◽  
Vol 98 (5) ◽  
pp. 1900-1908 ◽  
Author(s):  
James G. Tidball
Keyword(s):  
Skeletal Muscle ◽  
Signal Transduction ◽  
Mechanical Activation ◽  
Signaling Pathways ◽  
Mechanical Stimulation ◽  
Muscle Growth ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Mechanical Signal ◽  
Igf I

The adaptability of skeletal muscle to changes in the mechanical environment has been well characterized at the tissue and system levels, but the mechanisms through which mechanical signals are transduced to chemical signals that influence muscle growth and metabolism remain largely unidentified. However, several findings have suggested that mechanical signal transduction in muscle may occur through signaling pathways that are shared with insulin-like growth factor (IGF)-I. The involvement of IGF-I-mediated signaling for mechanical signal transduction in muscle was originally suggested by the observations that muscle releases IGF-I on mechanical stimulation, that IGF-I is a potent agent for promoting muscle growth and affecting phenotype, and that IGF-I can function as an autocrine hormone in muscle. Accumulating evidence shows that at least two signaling pathways downstream of IGF-I binding can influence muscle growth and adaptation. Signaling via the calcineurin/nuclear factor of activated T-cell pathway has been shown to have a powerful influence on promoting the slow/type I phenotype in muscle but can also increase muscle mass. Neural stimulation of muscle can activate this pathway, although whether neural activation of the pathway can occur independent of mechanical activation or independent of IGF-I-mediated signaling remains to be explored. Signaling via the Akt/mammalian target of rapamycin pathway can also increase muscle growth, and recent findings show that activation of this pathway can occur as a response to mechanical stimulation applied directly to muscle cells, independent of signals derived from other cells. In addition, mechanical activation of mammalian target of rapamycin, Akt, and other downstream signals is apparently independent of autocrine factors, which suggests that activation of the mechanical pathway occurs independent of muscle-mediated IGF-I release.

scholarly journals β-catenin-mediated Wnt signal transduction proceeds through an endocytosis-independent mechanism

2020 ◽  
Vol 31 (13) ◽  
pp. 1425-1436 ◽  
Author(s):  
Ellen Youngsoo Rim ◽  
Leigh Katherine Kinney ◽  
Roeland Nusse
Keyword(s):  
Signal Transduction ◽  
Real Time ◽  
Cell Lines ◽  
Wnt Pathway ◽  
Receptor Endocytosis ◽  
Pathway Activation ◽  
Independent Mechanism ◽  
Multiple Cell ◽  
Wnt Signal ◽  
Time Assessment

A novel tool for quantitative, real-time assessment of Wnt pathway activation was combined with genetic disruption of endocytosis to determine whether receptor endocytosis is required for Wnt signal transduction. Our results in multiple cell lines support that clathrin- or caveolin-mediated endocytosis is dispensable for Wnt signal transduction.

A surface-engineered NIR light-responsive actuator for controllable modulation of collective cell migration

2019 ◽  
Vol 7 (36) ◽  
pp. 5528-5534 ◽  
Author(s):  
Jiayu Liu ◽  
Jinhui Shang ◽  
Yancao Chen ◽  
Yueyue Tian ◽  
Qian Yang ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cell Migration ◽  
Live Cells ◽  
Collective Cell Migration ◽  
Nir Light ◽  
Mechanical Signal

A surface-engineered NIR light-responsive actuator has been presented for manipulating collective cell migration by activating mechanical signal transduction in live cells.

scholarly journals Oncostatin M Receptor-mediated Signal Transduction Is Negatively Regulated by SOCS3 through a Receptor Tyrosine-independent Mechanism

2006 ◽  
Vol 281 (13) ◽  
pp. 8458-8468 ◽  
Author(s):  
Claudia Stross ◽  
Simone Radtke ◽  
Thomas Clahsen ◽  
Christa Gerlach ◽  
Rudolf Volkmer-Engert ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Oncostatin M ◽  
Independent Mechanism ◽  
Oncostatin M Receptor

scholarly journals The Receptor-like Kinase FERONIA Is Required for Mechanical Signal Transduction in Arabidopsis Seedlings

2014 ◽  
Vol 24 (16) ◽  
pp. 1887-1892 ◽  
Author(s):  
Han-Wei Shih ◽  
Nathan D. Miller ◽  
Cheng Dai ◽  
Edgar P. Spalding ◽  
Gabriele B. Monshausen
Keyword(s):  
Signal Transduction ◽  
Receptor Like Kinase ◽  
Mechanical Signal

scholarly journals How Is The Cytoskeleleton Involved In Mechanical Signal Transduction?

1997 ◽  
Vol 5 (5) ◽  
pp. 18-18
Author(s):  
Judy M. Strum
Keyword(s):  
Signal Transduction ◽  
Extracellular Matrix ◽  
Living Cell ◽  
Molecular Network ◽  
Mechanical Signal ◽  
The Matrix ◽  
Sense And Respond ◽  
Underlying Mechanisms ◽  
External Stimuli

The underlying mechanisms whereby cells sense and respond to external stimuli are not well understood, but for some time it has been known that the extracellular matrix has an influence on the behavior of cells. For example, changing the flexibility and/or adhesiveness of the matrix can change the shape of cells, and determine whether or not they continue to divide or begin to differentiate. Recently, in a series of elegant experiments, a group of cell biologists in Boston have demonstrated the presence of an interconnected molecular network pervading the entire living cell, extending from its outer surroundings into the genes in its nucleus.

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