scholarly journals A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of epithelial cells

2004 ◽  
Vol 117 (7) ◽  
pp. 1247-1257 ◽  
Author(s):  
M. Matsuda
Keyword(s):  
Epithelial Cells ◽  
Tight Junction ◽  
Adhesion Molecules ◽  
Intercellular Movement

scholarly journals Tight junctions in Schwann cells of peripheral myelinated axons

2005 ◽  
Vol 169 (3) ◽  
pp. 527-538 ◽  
Author(s):  
Tatsuo Miyamoto ◽  
Kazumasa Morita ◽  
Daisuke Takemoto ◽  
Kosei Takeuchi ◽  
Yuka Kitano ◽  
...  
Keyword(s):  
Nervous System ◽  
Epithelial Cells ◽  
Tight Junction ◽  
Adhesion Molecules ◽  
Schwann Cells ◽  
Nerve Conduction ◽  
Physiological Function ◽  
Node Of Ranvier ◽  
Behavioral Abnormalities ◽  
Deficient Mice

Tight junction (TJ)–like structures have been reported in Schwann cells, but their molecular composition and physiological function remain elusive. We found that claudin-19, a novel member of the claudin family (TJ adhesion molecules in epithelia), constituted these structures. Claudin-19–deficient mice were generated, and they exhibited behavioral abnormalities that could be attributed to peripheral nervous system deficits. Electrophysiological analyses showed that the claudin-19 deficiency affected the nerve conduction of peripheral myelinated fibers. Interestingly, the overall morphology of Schwann cells lacking claudin-19 expression appeared to be normal not only in the internodal region but also at the node of Ranvier, except that TJs completely disappeared, at least from the outer/inner mesaxons. These findings have indicated that, similar to epithelial cells, Schwann cells also bear claudin-based TJs, and they have also suggested that these TJs are not involved in the polarized morphogenesis but are involved in the electrophysiological “sealing” function of Schwann cells.

scholarly journals JunD Represses Transcription and Translation of the Tight Junction Protein Zona Occludens-1 Modulating Intestinal Epithelial Barrier Function

2008 ◽  
Vol 19 (9) ◽  
pp. 3701-3712 ◽  
Author(s):  
Jie Chen ◽  
Lan Xiao ◽  
Jaladanki N. Rao ◽  
Tongtong Zou ◽  
Lan Liu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Tight Junction ◽  
Barrier Function ◽  
Intestinal Epithelial Cells ◽  
Binding Protein ◽  
Mrna Translation ◽  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Epithelial Barrier Function

The AP-1 transcription factor JunD is highly expressed in intestinal epithelial cells, but its exact role in maintaining the integrity of intestinal epithelial barrier remains unknown. The tight junction (TJ) protein zonula occludens (ZO)-1 links the intracellular domain of TJ-transmembrane proteins occludin, claudins, and junctional adhesion molecules to many cytoplasmic proteins and the actin cytoskeleton and is crucial for assembly of the TJ complex. Here, we show that JunD negatively regulates expression of ZO-1 and is implicated in the regulation of intestinal epithelial barrier function. Increased JunD levels by ectopic overexpression of the junD gene or by depleting cellular polyamines repressed ZO-1 expression and increased epithelial paracellular permeability. JunD regulated ZO-1 expression at the levels of transcription and translation. Transcriptional repression of ZO-1 by JunD was mediated through cAMP response element-binding protein-binding site within its proximal region of the ZO-1-promoter, whereas induced JunD inhibited ZO-1 mRNA translation by enhancing the interaction of the ZO-1 3′-untranslated region with RNA-binding protein T cell-restricted intracellular antigen 1-related protein. These results indicate that JunD is a biological suppressor of ZO-1 expression in intestinal epithelial cells and plays a critical role in maintaining epithelial barrier function.

scholarly journals Recovery from Oxidative Stress: Effects on the Tight Junction in Epithelial Cells.

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
D'Ann E. Arthur ◽  
Jeannette E. Gonzalez ◽  
Jonathan M. King
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Tight Junction ◽  
Stress Effects
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