scholarly journals Lactobacillus acidophilus Attenuates Salmonella-Induced Stress of Epithelial Cells by Modulating Tight-Junction Genes and Cytokine Responses

2018 ◽  
Vol 9 ◽  
Author(s):  
Alexia F. P. Lépine ◽  
Nicole de Wit ◽  
Els Oosterink ◽  
Harry Wichers ◽  
Jurriaan Mes ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Tight Junction ◽  
Lactobacillus Acidophilus ◽  
Cytokine Responses ◽  
Induced Stress

scholarly journals JunD Represses Transcription and Translation of the Tight Junction Protein Zona Occludens-1 Modulating Intestinal Epithelial Barrier Function

2008 ◽  
Vol 19 (9) ◽  
pp. 3701-3712 ◽  
Author(s):  
Jie Chen ◽  
Lan Xiao ◽  
Jaladanki N. Rao ◽  
Tongtong Zou ◽  
Lan Liu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Tight Junction ◽  
Barrier Function ◽  
Intestinal Epithelial Cells ◽  
Binding Protein ◽  
Mrna Translation ◽  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Epithelial Barrier Function

The AP-1 transcription factor JunD is highly expressed in intestinal epithelial cells, but its exact role in maintaining the integrity of intestinal epithelial barrier remains unknown. The tight junction (TJ) protein zonula occludens (ZO)-1 links the intracellular domain of TJ-transmembrane proteins occludin, claudins, and junctional adhesion molecules to many cytoplasmic proteins and the actin cytoskeleton and is crucial for assembly of the TJ complex. Here, we show that JunD negatively regulates expression of ZO-1 and is implicated in the regulation of intestinal epithelial barrier function. Increased JunD levels by ectopic overexpression of the junD gene or by depleting cellular polyamines repressed ZO-1 expression and increased epithelial paracellular permeability. JunD regulated ZO-1 expression at the levels of transcription and translation. Transcriptional repression of ZO-1 by JunD was mediated through cAMP response element-binding protein-binding site within its proximal region of the ZO-1-promoter, whereas induced JunD inhibited ZO-1 mRNA translation by enhancing the interaction of the ZO-1 3′-untranslated region with RNA-binding protein T cell-restricted intracellular antigen 1-related protein. These results indicate that JunD is a biological suppressor of ZO-1 expression in intestinal epithelial cells and plays a critical role in maintaining epithelial barrier function.

scholarly journals Inflammatory Cytokine Profiles of Semen Influence Cytokine Responses of Cervicovaginal Epithelial Cells

2018 ◽  
Vol 9 ◽  
Author(s):  
Cosnet L. Rametse ◽  
Anthonio O. Adefuye ◽  
Abraham J. Olivier ◽  
Lyle Curry ◽  
Hoyam Gamieldien ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Inflammatory Cytokine ◽  
Cytokine Profiles ◽  
Cytokine Responses

scholarly journals Recovery from Oxidative Stress: Effects on the Tight Junction in Epithelial Cells.

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
D'Ann E. Arthur ◽  
Jeannette E. Gonzalez ◽  
Jonathan M. King
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Tight Junction ◽  
Stress Effects
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