scholarly journals Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model

2019 ◽  
Vol 12 (4) ◽  
pp. dmm038042 ◽  
Author(s):  
Teresa R. Taylor-Whiteley ◽  
Christine L. Le Maitre ◽  
James A. Duce ◽  
Caroline F. Dalton ◽  
David P. Smith
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Three Dimensional ◽  
Neural Cell ◽  
Cell Culture Model ◽  
Culture Model ◽  
Human Neural Cell

scholarly journals Recapitulating Amyloid ß and Tau Pathology in Human Neural Cell Culture Models—Clinical Implications

US Neurology ◽  
2015 ◽  
Vol 11 (02) ◽  
pp. 102 ◽  
Author(s):  
Se Hoon Choi ◽  
Young Hye Kim ◽  
Carla D’Avanzo ◽  
Jenna Aronson ◽  
Rudolph E Tanzi ◽  
...  
Keyword(s):  
Cell Culture ◽  
Three Dimensional ◽  
Amyloid Β ◽  
3D Cell Culture ◽  
Neural Cell ◽  
Cell Culture Model ◽  
Pathogenic Mechanisms ◽  
Culture Model ◽  
Culture Models ◽  
Human Neural Cell

The “amyloid β hypothesis” of Alzheimer’s disease (AD) has been the reigning hypothesis explaining pathogenic mechanisms of AD over the last two decades. However, this hypothesis has not been fully validated in animal models, and several major unresolved factors remain. We recently developed a human neural cell culture model of AD based on a three-dimensional (3D) cell culture system. This unique, cellular model recapitulates major events of the AD pathogenic cascade, including β-amyloid plaques and neurofibrillary tangles. Our 3D human neural cell culture model system provides a premise for a new generation of cellular AD models that can serve as a novel platform for studying pathogenic mechanisms and for high-throughput drug screening in a human brain-like environment.

scholarly journals A three-dimensional human neural cell culture model of Alzheimer’s disease

Nature ◽  
2014 ◽  
Vol 515 (7526) ◽  
pp. 274-278 ◽  
Author(s):  
Se Hoon Choi ◽  
Young Hye Kim ◽  
Matthias Hebisch ◽  
Christopher Sliwinski ◽  
Seungkyu Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Three Dimensional ◽  
Neural Cell ◽  
Cell Culture Model ◽  
Model Of Alzheimer’S Disease ◽  
Culture Model ◽  
Human Neural Cell

Dissecting Comorbidity between Parkinson’s Disease and Melanoma in a Cell Culture Model

2017 ◽  
Vol 31 (1_supplement) ◽  
pp. 631.1-631.1 ◽  
Author(s):  
Anindita Bose ◽  
Deborah Dele-Oni ◽  
Gregory Petsko
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Cell Culture Model ◽  
Culture Model ◽  
A Cell
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