scholarly journals A three-dimensional human neural cell culture model of Alzheimer’s disease

Nature ◽  
2014 ◽  
Vol 515 (7526) ◽  
pp. 274-278 ◽  
Author(s):  
Se Hoon Choi ◽  
Young Hye Kim ◽  
Matthias Hebisch ◽  
Christopher Sliwinski ◽  
Seungkyu Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Three Dimensional ◽  
Neural Cell ◽  
Cell Culture Model ◽  
Model Of Alzheimer’S Disease ◽  
Culture Model ◽  
Human Neural Cell

scholarly journals Proteomics of the human neuronal cell culture model of Alzheimer's disease

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S109
Author(s):  
Min-Young Song ◽  
Da Kyeong Park ◽  
Chaewon Park ◽  
Dain Kim ◽  
Soo Youn Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Neuronal Cell ◽  
Cell Culture Model ◽  
Neuronal Cell Culture ◽  
Human Neuronal Cell ◽  
Model Of Alzheimer’S Disease ◽  
Culture Model

scholarly journals A Three-Dimensional Alzheimer’s Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1

2020 ◽  
Vol 14 ◽  
Author(s):  
Mercedes A. Hernández-Sapiéns ◽  
Edwin E. Reza-Zaldívar ◽  
Ricardo R. Cevallos ◽  
Ana L. Márquez-Aguirre ◽  
Karlen Gazarian ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Three Dimensional ◽  
Cell Culture Model ◽  
Culture Model ◽  
Disease Cell

scholarly journals Recapitulating Amyloid ß and Tau Pathology in Human Neural Cell Culture Models—Clinical Implications

US Neurology ◽  
2015 ◽  
Vol 11 (02) ◽  
pp. 102 ◽  
Author(s):  
Se Hoon Choi ◽  
Young Hye Kim ◽  
Carla D’Avanzo ◽  
Jenna Aronson ◽  
Rudolph E Tanzi ◽  
...  
Keyword(s):  
Cell Culture ◽  
Three Dimensional ◽  
Amyloid Β ◽  
3D Cell Culture ◽  
Neural Cell ◽  
Cell Culture Model ◽  
Pathogenic Mechanisms ◽  
Culture Model ◽  
Culture Models ◽  
Human Neural Cell

The “amyloid β hypothesis” of Alzheimer’s disease (AD) has been the reigning hypothesis explaining pathogenic mechanisms of AD over the last two decades. However, this hypothesis has not been fully validated in animal models, and several major unresolved factors remain. We recently developed a human neural cell culture model of AD based on a three-dimensional (3D) cell culture system. This unique, cellular model recapitulates major events of the AD pathogenic cascade, including β-amyloid plaques and neurofibrillary tangles. Our 3D human neural cell culture model system provides a premise for a new generation of cellular AD models that can serve as a novel platform for studying pathogenic mechanisms and for high-throughput drug screening in a human brain-like environment.

scholarly journals Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model

2019 ◽  
Vol 12 (4) ◽  
pp. dmm038042 ◽  
Author(s):  
Teresa R. Taylor-Whiteley ◽  
Christine L. Le Maitre ◽  
James A. Duce ◽  
Caroline F. Dalton ◽  
David P. Smith
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Three Dimensional ◽  
Neural Cell ◽  
Cell Culture Model ◽  
Culture Model ◽  
Human Neural Cell

scholarly journals Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Sang Su Kwak ◽  
Kevin J. Washicosky ◽  
Emma Brand ◽  
Djuna von Maydell ◽  
Jenna Aronson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Neural Cell ◽  
Tau Pathology ◽  
Culture Models ◽  
Cell Culture Models ◽  
Human Neural Cell

scholarly journals A 3D human neural cell culture system for modeling Alzheimer's disease

2015 ◽  
Vol 10 (7) ◽  
pp. 985-1006 ◽  
Author(s):  
Young Hye Kim ◽  
Se Hoon Choi ◽  
Carla D'Avanzo ◽  
Matthias Hebisch ◽  
Christopher Sliwinski ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Culture System ◽  
Neural Cell ◽  
Cell Culture System ◽  
Human Neural Cell
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