scholarly journals PEX13 deficiency in mouse brain as a model of Zellweger syndrome: abnormal cerebellum formation, reactive gliosis and oxidative stress

2010 ◽  
Vol 4 (1) ◽  
pp. 104-119 ◽  
Author(s):  
C. C. Muller ◽  
T. H. Nguyen ◽  
B. Ahlemeyer ◽  
M. Meshram ◽  
N. Santrampurwala ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Zellweger Syndrome ◽  
Reactive Gliosis ◽  
And Oxidative Stress

Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress

2015 ◽  
Vol 93 (9) ◽  
pp. 1423-1433 ◽  
Author(s):  
Lucia García-Lara ◽  
Francisca Pérez-Severiano ◽  
Dinora González-Esquivel ◽  
Guillermo Elizondo ◽  
José Segovia
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Kynurenic Acid ◽  
Aryl Hydrocarbon Receptors ◽  
Aryl Hydrocarbon ◽  
And Oxidative Stress

Protective effects of erythropoietin against ethanol-induced apoptotic neurodegenaration and oxidative stress in the developing C57BL/6 mouse brain

2005 ◽  
Vol 160 (2) ◽  
pp. 146-156 ◽  
Author(s):  
Abdullah Kumral ◽  
Kazim Tugyan ◽  
Sevil Gonenc ◽  
Kursat Genc ◽  
Sermin Genc ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Protective Effects ◽  
And Oxidative Stress

Protective effect of Cyperus esculentus (tiger nut) extract against scopolamine-induced memory loss and oxidative stress in mouse brain

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Solomon Umukoro ◽  
Love Okoh ◽  
Sylvester C. Igweze ◽  
Abayomi M. Ajayi ◽  
Benneth Ben-Azu
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Ache Activity ◽  
Memory Loss ◽  
Cognitive Disorder ◽  
Cyperus Esculentus ◽  
Oxidative Stress Biomarkers ◽  
Beneficial Effects ◽  
Stress Biomarkers ◽  
And Oxidative Stress

AbstractObjectivesThe juice extract of Cyperus esculentus commonly known as tiger nuts (TINUT) is widely used for its numerous health promoting effects including alleviation of symptoms associated with neurological disorders. Herein, we investigated the influence of the aqueous extract of C. esculentus on cognitive disorder and the underlying changes in acetylcholinesterase (AChE) activity and oxidative stress biomarkers in mice exposed to scopolamine.MethodsC. esculentus (50–200 mg/kg) or saline (10 mL/kg) was given alone or with scopolamine 30 min after, to male Swiss mice (6/group) daily for seven days. We evaluated the cognitive performance using Y-maze and object recognition on day seven post-treatment. Brains of the animals were afterwards processed for spectrophotometric determination of AChE activity and contents of oxidative stress biomarkers (malondialdehyde [MDA], glutathione [GSH], catalase, superoxide dismutase and nitrite).ResultsThe extract improves cognitive function and also upturned scopolamine amnesia in mice. The extract markedly reduced brain AChE, MDA, and nitrite contents in mice injected with scopolamine (p<0.05). It also attenuated scopolamine-induced deregulated GSH contents and antioxidant enzymes in mouse brain.ConclusionsThe results of this study suggest that regular consumption of TINUT might offer beneficial effects in memory-related disorders.

scholarly journals Mitochondrial changes and oxidative stress in a mouse model of Zellweger syndrome neuropathogenesis

Neuroscience ◽  
2016 ◽  
Vol 334 ◽  
pp. 201-213 ◽  
Author(s):  
Rani Sadia Rahim ◽  
Mo Chen ◽  
C. Cathrin Nourse ◽  
Adrian C.B. Meedeniya ◽  
Denis I. Crane
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Zellweger Syndrome ◽  
And Oxidative Stress

scholarly journals Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain

Toxicology ◽  
2016 ◽  
Vol 374 ◽  
pp. 1-9 ◽  
Author(s):  
Toby B. Cole ◽  
Jacki Coburn ◽  
Khoi Dao ◽  
Pam Roqué ◽  
Yu-Chi Chang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Diesel Exhaust ◽  
Genetic Differences ◽  
Diesel Exhaust Exposure ◽  
And Oxidative Stress

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

Sign in / Sign up

Export Citation Format

Share Document