Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress

2015 ◽  
Vol 93 (9) ◽  
pp. 1423-1433 ◽  
Author(s):  
Lucia García-Lara ◽  
Francisca Pérez-Severiano ◽  
Dinora González-Esquivel ◽  
Guillermo Elizondo ◽  
José Segovia
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Kynurenic Acid ◽  
Aryl Hydrocarbon Receptors ◽  
Aryl Hydrocarbon ◽  
And Oxidative Stress

Protective effects of erythropoietin against ethanol-induced apoptotic neurodegenaration and oxidative stress in the developing C57BL/6 mouse brain

2005 ◽  
Vol 160 (2) ◽  
pp. 146-156 ◽  
Author(s):  
Abdullah Kumral ◽  
Kazim Tugyan ◽  
Sevil Gonenc ◽  
Kursat Genc ◽  
Sermin Genc ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Protective Effects ◽  
And Oxidative Stress

scholarly journals PEX13 deficiency in mouse brain as a model of Zellweger syndrome: abnormal cerebellum formation, reactive gliosis and oxidative stress

2010 ◽  
Vol 4 (1) ◽  
pp. 104-119 ◽  
Author(s):  
C. C. Muller ◽  
T. H. Nguyen ◽  
B. Ahlemeyer ◽  
M. Meshram ◽  
N. Santrampurwala ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Zellweger Syndrome ◽  
Reactive Gliosis ◽  
And Oxidative Stress

Protective effect of Cyperus esculentus (tiger nut) extract against scopolamine-induced memory loss and oxidative stress in mouse brain

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Solomon Umukoro ◽  
Love Okoh ◽  
Sylvester C. Igweze ◽  
Abayomi M. Ajayi ◽  
Benneth Ben-Azu
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Ache Activity ◽  
Memory Loss ◽  
Cognitive Disorder ◽  
Cyperus Esculentus ◽  
Oxidative Stress Biomarkers ◽  
Beneficial Effects ◽  
Stress Biomarkers ◽  
And Oxidative Stress

AbstractObjectivesThe juice extract of Cyperus esculentus commonly known as tiger nuts (TINUT) is widely used for its numerous health promoting effects including alleviation of symptoms associated with neurological disorders. Herein, we investigated the influence of the aqueous extract of C. esculentus on cognitive disorder and the underlying changes in acetylcholinesterase (AChE) activity and oxidative stress biomarkers in mice exposed to scopolamine.MethodsC. esculentus (50–200 mg/kg) or saline (10 mL/kg) was given alone or with scopolamine 30 min after, to male Swiss mice (6/group) daily for seven days. We evaluated the cognitive performance using Y-maze and object recognition on day seven post-treatment. Brains of the animals were afterwards processed for spectrophotometric determination of AChE activity and contents of oxidative stress biomarkers (malondialdehyde [MDA], glutathione [GSH], catalase, superoxide dismutase and nitrite).ResultsThe extract improves cognitive function and also upturned scopolamine amnesia in mice. The extract markedly reduced brain AChE, MDA, and nitrite contents in mice injected with scopolamine (p<0.05). It also attenuated scopolamine-induced deregulated GSH contents and antioxidant enzymes in mouse brain.ConclusionsThe results of this study suggest that regular consumption of TINUT might offer beneficial effects in memory-related disorders.

scholarly journals Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain

Toxicology ◽  
2016 ◽  
Vol 374 ◽  
pp. 1-9 ◽  
Author(s):  
Toby B. Cole ◽  
Jacki Coburn ◽  
Khoi Dao ◽  
Pam Roqué ◽  
Yu-Chi Chang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Diesel Exhaust ◽  
Genetic Differences ◽  
Diesel Exhaust Exposure ◽  
And Oxidative Stress
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