Surface potentials and the control of amphibian limb regeneration

Development ◽  
1979 ◽  
Vol 53 (1) ◽  
pp. 213-223
Author(s):  
B. Lassalle
Keyword(s):  
Wound Healing ◽  
Limb Regeneration ◽  
Wound Surface ◽  
Surface Potentials ◽  
Variable Period ◽  
The Relationship

The relationship between surface potentials and amphibian limb regeneration is examined. The wound surface becomes increasingly positive for several days after amputation but then decreases again, often becoming negative for a variable period during blastemal growth. The same changes of surface potentials are observed during wound healing alone, in the absence of amputation and following amputation of irradiated or denervated limbs. Similar changes occur in non-regenerating frog arms. These observations and other cited reasons lead to the conclusion that surface potentials do not control regeneration.

scholarly journals The assessment and management of hypergranulation

2021 ◽  
Vol 30 (5) ◽  
pp. S6-S10
Author(s):  
Aby Mitchell ◽  
Doris Llumigusin
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Wound Surface ◽  
Wound Area ◽  
Nutritional Deficit

Wound healing follows a process of four distinct phases: haemostasis, inflammation, proliferation and maturation. Problems can arise in any of these phases, delaying the wound process. Hypergranulation (also known as overgranulation) during the proliferation phase occurs when granulation tissue over grows beyond the wound surface. Such wounds have a discoloured, raised or swollen appearance and bleed easily. The cause may be infection, the effects of friction on the wound area, nutritional deficit or stress. Treatments will depend on the cause. There is a lack of studies on treatments for hypergranulaton and more research is required.

scholarly journals Assessment of Frailty In Elderly Patients Attending A Multidisciplinary Wound Care Center: A Cohort Study.

2021 ◽  
Author(s):  
Mariona Espaulella-Ferrer ◽  
Joan Espaulella-Panicot ◽  
Rosa Noell-Boix ◽  
Marta Casals-Zorita ◽  
Marta Ferrer-Sola ◽  
...  
Keyword(s):  
Wound Healing ◽  
Elderly Patients ◽  
Healing Rate ◽  
Wound Care ◽  
Frailty Index ◽  
Healing Time ◽  
Venous Ulcers ◽  
Healing Wounds ◽  
Wound Healing Time ◽  
The Relationship

Abstract Background: The incidence of frailty and chronic wounds increases with patients’ age. Knowledge of the relationship between frailty and wound healing progress is greatly lacking. Methods: The aim of this study is to characterize the degree of frailty in elderly patients attending a multidisciplinary wound care centers (MWCC). Additionally, we seek to assess the impact of frailty on the wound healing rate and wound healing time. An open cohort study was conducted on 51 consecutive patients aged > 70 years treated for wounds at an MWCC of an intermediate care hospital. The frailty score was determined according to the Frail-VIG index. Data were collected through patient questionnaires at the beginning of the study, and at six months or upon wound healing. Wounds were followed up every two weeks. To analyze the relationship between two variables was used the Chi-square test and Student’s or the ANOVA model. The t-test for paired data was used to analyze the evolution of the frailty index during follow-up.Results: A total of 51 consecutive patients were included (aged 81.1 ± 6.1 years). Frailty prevalence was 74.5% according to the Frail-VIG index (47.1% mildly frail, 19.6% moderately frail, and 7.8% severely frail). Wounds healed in 69.6% of cases at six months. The frailty index (FI) was higher in patients with non-healing wounds in comparison with patients with healing wounds (IF 0.31 ± 0.15 vs IF 0.24 ± 0.11, p=0.043). A strong correlation between FI and wound healing results was observed in patients with non-venous ulcers (FI 0.37 ± 0.13 vs FI 0.27 ± 0.10, p=0.015). However, no correlation was observed in patients with venous ulcers (FI 0.17 ± 0.09 vs FI 0.19 ± 0.09, p=0.637). Wound healing rate is statically significantly higher in non-frail patients (3,26% wound reduction/day, P25-P75 0.8-8.8%/day) in comparison with frail patients (8.9% wound reduction/day, P25-P75 3.34-18.3%/day; p=0.044). Conclusion: Frailty is prevalent in elderly patients treated at an MWCC. Frailty degree is correlated with wound healing results and wound healing time.

The Relationship between Neutrophils and Incisional Wound Healing

2001 ◽  
Vol 14 (2) ◽  
pp. 108-116 ◽  
Author(s):  
Nuh Zafer Cantürk ◽  
Nilüfer Esen ◽  
Birol Vural ◽  
Zeynep Cantürk ◽  
Guldal Kirkali ◽  
...  
Keyword(s):  
Wound Healing ◽  
The Relationship

Role of prostaglandins in amphibian limb regeneration

1981 ◽  
Vol 59 (1) ◽  
pp. 136-137
Author(s):  
Steven R. Scadding
Keyword(s):  
Wound Healing ◽  
Acetylsalicylic Acid ◽  
Limb Regeneration ◽  
Limb Amputation ◽  
Prostaglandin E ◽  
Notophthalmus Viridescens ◽  
Bufo Americanus ◽  
Histological Appearance

Following limb amputation in the newt (Notophthalmus viridescens), the animals were given daily intraperitoneal injections of 0.1 or 1.0 mg of either indomethacin or acetylsalicylic acid. This had no observable influence on the rate or extent of limb regeneration or the histological appearance of the regenerating limb when compared with controls. Following limb amputation in toads (Bufo americanus), the limb stumps were injected daily for the first 15 days after amputation with 5 μg of either prostaglandin E1 or prostaglandin E2. Neither of these treatments had any observed effect on subsequent wound healing of the limbs when compared with controls. These observations suggest that prostaglandins do not play a major role in control of amphibian limb regeneration.

scholarly journals An Intelligent and Smart Environment Monitoring System for Healthcare

2019 ◽  
Vol 9 (19) ◽  
pp. 4172 ◽  
Author(s):  
Hina Sattar ◽  
Imran Sarwar Bajwa ◽  
Riaz Ul-Amin ◽  
Aqsa Mahmood ◽  
Waheed Anwar ◽  
...  
Keyword(s):  
Wound Healing ◽  
Monitoring System ◽  
Wound Care ◽  
Healing Process ◽  
Research Work ◽  
Wound Healing Process ◽  
Wound Surface ◽  
Environment Monitoring ◽  
Environment Effect ◽  
Impaired Wound Healing

Skin wound healing is influenced by two kinds of environment i.e., exterior environment that is nearby to wound surface and interior environment that is the environment of the adjacent part under wound surface. Both types of environment play a vital role in wound healing, which may contribute to continuous or impaired wound healing. Although, different previous studies provided wound care solutions, but they focused on single environmental factors either wound moisture level, pH value or healing enzymes. Practically, it is insignificant to consider environmental effect by determination of single factors or two, as both types of environment contain a lot of other factors which must be part of investigation e.g., smoke, air pollution, air humidity, temperature, hydrogen gases etc. Also, previous studies didn’t classify overall healing either as continuous or impaired based on exterior environment effect. In current research work, we proposed an effective wound care solution based on exterior environment monitoring system integrated with Neural Network Model to consider exterior environment effect on wound healing process, either as continuous or impaired. Current research facilitates patients by providing them intelligent wound care solution to monitor and control wound healing at their home.

Hydrosurgical debridement as an approach to wound healing: an animal thermal burn model

2019 ◽  
Vol 28 (5) ◽  
pp. 304-311
Author(s):  
Eiko Hirokawa ◽  
Tomoya Sato ◽  
Takashi Fujino ◽  
Yoshiya Gotoh ◽  
Hideki Yokogawa ◽  
...  
Keyword(s):  
Wound Healing ◽  
Blood Loss ◽  
Vascular Endothelial Cell ◽  
Surgical Debridement ◽  
Wound Surface ◽  
Thermal Burn ◽  
Scar Contracture ◽  
Wound Debridement ◽  
Short Period ◽  
Blood Loss Volume

Objective: This study investigates the advantages of hydrosurgical debridement compared with surgical debridement. Method: Thermal skin burns were created on the backs of male Wistar rats. Surgical debridement was used to treat one wound and hydrosurgical debridement (Versajet Hydrosurgery System, Smith&Nephew, UK) used to treat the second wound. Debridement time, blood loss volume, time-to-heal and histologic changes in the wound areas were compared. Results: A total of 23 rats were used in the study. Debridement time and time-to-heal were significantly shorter with hydrosurgical debridement than with surgical debridement (p<0.01 and p<0.05, respectively). Blood loss volume was significantly less with hydrosurgical debridement (p<0.01), and the wound surface area was significantly smaller on days two (p<0.01), four (p<0.05) and seven (p<0.05). Dense inflammatory cell infiltration into dermal muscle was deeper after surgical debridement (p=0.017). Reactive fibrotic tissue at the wound surface was significantly thinner (p<0.001) and the vascular endothelial cell count was significantly higher (p<0.001) after hydrosurgical debridement. Conclusion: The hydrosurgical system used appears to provide for minimally invasive debridement that can be performed in a relatively short period of time. Use of the device appears to minimise injury to healthy tissue and ameliorate inflammation, which in turn promotes early wound healing and reduces scar contracture. Hydrosurgical debridement appears to cause less damage to normal tissues. Furthermore, it is easier and requires less time.

scholarly journals The relationship between cytokine concentrations and wound healing in chronic venous ulceration

2008 ◽  
Vol 48 (5) ◽  
pp. 1272-1277 ◽  
Author(s):  
Manjit S. Gohel ◽  
Robin A.J. Windhaber ◽  
John F. Tarlton ◽  
Mark R. Whyman ◽  
Keith R. Poskitt
Keyword(s):  
Wound Healing ◽  
Venous Ulceration ◽  
The Relationship

Fabrication of hydroxyapatite/chitosan composite hydrogels loaded with exosomes derived from miR-126-3p overexpressed synovial mesenchymal stem cells for diabetic chronic wound healing

2016 ◽  
Vol 4 (42) ◽  
pp. 6830-6841 ◽  
Author(s):  
Min Li ◽  
Qin-Fei Ke ◽  
Shi-Cong Tao ◽  
Shang-Chun Guo ◽  
Bi-Yu Rui ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Chronic Wound ◽  
Wound Surface ◽  
Composite Hydrogels ◽  
Chitosan Composite

Hydroxyapatite/chitosan composite hydrogels loaded with exosomes was fabricated for promoting wound surface re-epithelialization, angiogenesis, collagen maturity and diabetic chronic wound healing.

scholarly journals Increased burn healing time is associated with higher Vancouver Scar Scale score

2017 ◽  
Vol 3 ◽  
pp. 205951311769632 ◽  
Author(s):  
Vidya Finlay ◽  
Sally Burrows ◽  
Maddison Burmaz ◽  
Hussna Yawary ◽  
Johanna Lee ◽  
...  
Keyword(s):  
Wound Healing ◽  
Total Body Surface Area ◽  
Likelihood Estimation ◽  
Healing Time ◽  
Burn Wound ◽  
Interaction Terms ◽  
Burn Wound Healing ◽  
Primary Model ◽  
Burn Surgery ◽  
The Relationship

[Formula: see text] Increased burn wound healing time has been shown to influence abnormal scarring. This study hypothesised that scar severity increases commensurate to the increase in time to healing (TTH) of the wound. Wound healing and scar data from burn patients treated by the Burn Service of Western Australia at Royal Perth Hospital were examined. The relationship between TTH and scar severity, as assessed by the modified Vancouver Scar Scale (mVSS), was modelled using regression analysis. Interaction terms evaluated the effect of surgery and total body surface area – burn (TBSA) on the main relationship. Maximum likelihood estimation was used to account for potential bias from missing independent variable data. The sample had a median age of 34 years, TTH of 24 days, TBSA of 3% and length of stay of five days, 70% were men and 71% had burn surgery. For each additional day of TTH, the mVSS score increased by 0.11 points ( P ≤ 0.001) per day in the first 21 days and 0.02 points per day thereafter ( P = 0.004). The relationship remained stable in spite of TBSA or surgical intervention. Investigation of the effect of missing data revealed the primary model underestimated the strength of the association. An increase in TTH within 21 days of injury is associated with an increase in mVSS or reduced scar quality. The results confirm that efforts should be directed toward healing burn wounds as early as possible.

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