scholarly journals The relationship between cytokine concentrations and wound healing in chronic venous ulceration

2008 ◽  
Vol 48 (5) ◽  
pp. 1272-1277 ◽  
Author(s):  
Manjit S. Gohel ◽  
Robin A.J. Windhaber ◽  
John F. Tarlton ◽  
Mark R. Whyman ◽  
Keith R. Poskitt
Keyword(s):  
Wound Healing ◽  
Venous Ulceration ◽  
The Relationship

scholarly journals Assessment of Frailty In Elderly Patients Attending A Multidisciplinary Wound Care Center: A Cohort Study.

2021 ◽  
Author(s):  
Mariona Espaulella-Ferrer ◽  
Joan Espaulella-Panicot ◽  
Rosa Noell-Boix ◽  
Marta Casals-Zorita ◽  
Marta Ferrer-Sola ◽  
...  
Keyword(s):  
Wound Healing ◽  
Elderly Patients ◽  
Healing Rate ◽  
Wound Care ◽  
Frailty Index ◽  
Healing Time ◽  
Venous Ulcers ◽  
Healing Wounds ◽  
Wound Healing Time ◽  
The Relationship

Abstract Background: The incidence of frailty and chronic wounds increases with patients’ age. Knowledge of the relationship between frailty and wound healing progress is greatly lacking. Methods: The aim of this study is to characterize the degree of frailty in elderly patients attending a multidisciplinary wound care centers (MWCC). Additionally, we seek to assess the impact of frailty on the wound healing rate and wound healing time. An open cohort study was conducted on 51 consecutive patients aged > 70 years treated for wounds at an MWCC of an intermediate care hospital. The frailty score was determined according to the Frail-VIG index. Data were collected through patient questionnaires at the beginning of the study, and at six months or upon wound healing. Wounds were followed up every two weeks. To analyze the relationship between two variables was used the Chi-square test and Student’s or the ANOVA model. The t-test for paired data was used to analyze the evolution of the frailty index during follow-up.Results: A total of 51 consecutive patients were included (aged 81.1 ± 6.1 years). Frailty prevalence was 74.5% according to the Frail-VIG index (47.1% mildly frail, 19.6% moderately frail, and 7.8% severely frail). Wounds healed in 69.6% of cases at six months. The frailty index (FI) was higher in patients with non-healing wounds in comparison with patients with healing wounds (IF 0.31 ± 0.15 vs IF 0.24 ± 0.11, p=0.043). A strong correlation between FI and wound healing results was observed in patients with non-venous ulcers (FI 0.37 ± 0.13 vs FI 0.27 ± 0.10, p=0.015). However, no correlation was observed in patients with venous ulcers (FI 0.17 ± 0.09 vs FI 0.19 ± 0.09, p=0.637). Wound healing rate is statically significantly higher in non-frail patients (3,26% wound reduction/day, P25-P75 0.8-8.8%/day) in comparison with frail patients (8.9% wound reduction/day, P25-P75 3.34-18.3%/day; p=0.044). Conclusion: Frailty is prevalent in elderly patients treated at an MWCC. Frailty degree is correlated with wound healing results and wound healing time.

The Relationship between Neutrophils and Incisional Wound Healing

2001 ◽  
Vol 14 (2) ◽  
pp. 108-116 ◽  
Author(s):  
Nuh Zafer Cantürk ◽  
Nilüfer Esen ◽  
Birol Vural ◽  
Zeynep Cantürk ◽  
Guldal Kirkali ◽  
...  
Keyword(s):  
Wound Healing ◽  
The Relationship

scholarly journals Increased burn healing time is associated with higher Vancouver Scar Scale score

2017 ◽  
Vol 3 ◽  
pp. 205951311769632 ◽  
Author(s):  
Vidya Finlay ◽  
Sally Burrows ◽  
Maddison Burmaz ◽  
Hussna Yawary ◽  
Johanna Lee ◽  
...  
Keyword(s):  
Wound Healing ◽  
Total Body Surface Area ◽  
Likelihood Estimation ◽  
Healing Time ◽  
Burn Wound ◽  
Interaction Terms ◽  
Burn Wound Healing ◽  
Primary Model ◽  
Burn Surgery ◽  
The Relationship

[Formula: see text] Increased burn wound healing time has been shown to influence abnormal scarring. This study hypothesised that scar severity increases commensurate to the increase in time to healing (TTH) of the wound. Wound healing and scar data from burn patients treated by the Burn Service of Western Australia at Royal Perth Hospital were examined. The relationship between TTH and scar severity, as assessed by the modified Vancouver Scar Scale (mVSS), was modelled using regression analysis. Interaction terms evaluated the effect of surgery and total body surface area – burn (TBSA) on the main relationship. Maximum likelihood estimation was used to account for potential bias from missing independent variable data. The sample had a median age of 34 years, TTH of 24 days, TBSA of 3% and length of stay of five days, 70% were men and 71% had burn surgery. For each additional day of TTH, the mVSS score increased by 0.11 points ( P ≤ 0.001) per day in the first 21 days and 0.02 points per day thereafter ( P = 0.004). The relationship remained stable in spite of TBSA or surgical intervention. Investigation of the effect of missing data revealed the primary model underestimated the strength of the association. An increase in TTH within 21 days of injury is associated with an increase in mVSS or reduced scar quality. The results confirm that efforts should be directed toward healing burn wounds as early as possible.

scholarly journals Circular RNA hsa_circ_0032463 acts as a tumor promoter in osteosarcoma by regulating miR-498/LEF1 axis

2021 ◽  
Author(s):  
Guanghua Qin ◽  
Xuejian Wu
Keyword(s):  
Wound Healing ◽  
Cell Lines ◽  
Underlying Mechanism ◽  
Circular Rna ◽  
Inhibitory Effect ◽  
Experimental Results ◽  
Tumor Promoter ◽  
Qpcr Analysis ◽  
Proliferation And Apoptosis ◽  
The Relationship

Several studies have examined the relationship between osteosarcoma (OS) and microRNAs (miRNAs). However, only a few researchers have investigated the underlying mechanism of circRNAs in OS development. Our paper aimed to assess how circ_0032463 initiates and regulates OS progression. We detected circ_0032463 expression in OS tissues and cell lines using RT-qPCR analysis and then investigated the interaction between circ_0032463, miR-498 and LEF1 using RNA pull-down, RIP, and luciferase assays. The effect of the circ_0032463/miR-498/LEF1 axis on the migration, proliferation, and apoptosis levels of OS cells was explored using CCK-8, BrdU, wound healing, and FITC assays. Our findings revealed that circ_0032463 expression was upregulated in OS tissues and cell lines. We also found that circ_0032463 interacted with miR-498, thereby reducing the expression of miR-498 in OS cells. Experimental results indicated that miR-498 could directly target LEF1 in OS cells and that circ_0032463 could abrogate the tumor-inhibitory effect of miR-498 by upregulating LEF1 in OS. More specifically, by binding to miR-498 and inhibiting LEF1 expression, circ_0032463 promoted the migration and proliferation abilities of OS cells and suppressed the apoptosis ability of OS cells. Overall, this research suggested that circ_0032463 could promote OS development by regulating the miR-498/LEF1 axis.

scholarly journals miR-379-5p inhibits proliferation and invasion of the endometrial cancer cells by inhibiting expression of ROR1

2021 ◽  
Author(s):  
Minglin Liang ◽  
Hui Chen ◽  
Jie Min
Keyword(s):  
Wound Healing ◽  
Endometrial Cancer ◽  
Cancer Cells ◽  
Colony Formation ◽  
Inhibitory Effect ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Gynecological Malignancy ◽  
The Relationship ◽  
Proliferation And Invasion

Endometrial cancer is a common gynecological malignancy, and the incidence of this disease has increased in recent years. Recently, some studies suggested that the expression of miR-379-5p suppressed the metastasis of breast cancer cells. However, whether the expression of miR-379-5p could affect the proliferation, migration and invasion of endometrial cancer is unclear. In this study, we established miR-379-5p overexpression and miR-379-5p inhibition in endometrial cancer cells. Next, EdU and colony formation assays were performed to measure proliferation of endometrial cancer cells. Wound healing and transwell assays were carried out to examine the migration and invasion of these cells. Then, luciferase reporter assay was performed to test the relationship between miR-379-5p and ROR1. Finally, we overexpressed ROR1 in miR-379-5p overexpressing endometrial cancer cells. Colony formation, wound healing and transwell assays were used to measure proliferation, migration and invasion of these cells. The results showed that overexpression of miR-379-5p repressed proliferation, migration and invasion of endometrial cancer cells. Higher levels of miR-379-5p repressed expression of N-cadherin, Vimentin and ZEB1. Overexpression of miR-379-5p also promoted expression of E-cadherin and ZO-1. In addition, miR-379-5p targeted and suppressed expression of ROR1. Overexpression of ROR1 abolished the inhibitory effect of miR-379-5p on proliferation, migration, invasion and EMT of endometrial cancer cells. All of these results indicated that miR-379-5p suppressed proliferation, migration and invasion of endometrial cancer cells by inhibiting the expression of ROR1 and the EMT process.

scholarly journals Smoking Related Systemic and Oral Diseases

2007 ◽  
Vol 50 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Sajith Vellappally ◽  
Zdeněk Fiala ◽  
Jindra Šmejkalová ◽  
Vimal Jacob ◽  
Rakesh Somanathan
Keyword(s):  
Lung Cancer ◽  
Wound Healing ◽  
Survival Rate ◽  
Oral Cavity ◽  
Oral Candidiasis ◽  
Systemic Diseases ◽  
Oral Diseases ◽  
Implant Survival ◽  
Dental Restorations ◽  
The Relationship

This article reviewed smoking related systemic diseases and oral diseases. Smoking is related to lung cancer, cardiovascular diseases and many other systemic diseases. Cigarette smoke affects the oral cavity first, so it is evident that smoking has many negative influences on oral cavity, for example, staining of teeth and dental restorations, wound healing, reduction of the ability to smell and taste, and development of oral diseases such as oral cancer, periodontitis, smoker’s palate, smoker’s melanosis, hairy tongue, leukoplakia, oral candidiasis and implant survival rate. The article also discusses the relationship between smoking and dental caries in detail.

Surface potentials and the control of amphibian limb regeneration

Development ◽  
1979 ◽  
Vol 53 (1) ◽  
pp. 213-223
Author(s):  
B. Lassalle
Keyword(s):  
Wound Healing ◽  
Limb Regeneration ◽  
Wound Surface ◽  
Surface Potentials ◽  
Variable Period ◽  
The Relationship

The relationship between surface potentials and amphibian limb regeneration is examined. The wound surface becomes increasingly positive for several days after amputation but then decreases again, often becoming negative for a variable period during blastemal growth. The same changes of surface potentials are observed during wound healing alone, in the absence of amputation and following amputation of irradiated or denervated limbs. Similar changes occur in non-regenerating frog arms. These observations and other cited reasons lead to the conclusion that surface potentials do not control regeneration.

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