scholarly journals The effect of hydrocortisone on limb regeneration in the bullfrog tadpole, Rana catesbeiana

Development ◽  
1973 ◽  
Vol 29 (1) ◽  
pp. 65-71
Author(s):  
Judith S. Weis ◽  
Larry P. Bleier
Keyword(s):  
Connective Tissue ◽  
Rana Catesbeiana ◽  
Early Stage ◽  
Limb Regeneration ◽  
Connective Tissue Layer ◽  
Ability To Regenerate ◽  
Rapid Healing ◽  
Bullfrog Tadpole ◽  
Well Differentiated ◽  
Cut Surface

Tadpoles of the bullfrog Rana catesbeiana lose the ability to regenerate limbs amputated through the femur at a very early stage in development. Well-differentiated limbs which in other species can regenerate if amputated through the ankle, cannot in this species. Non-regenerating tadpole limbs either show rapid healing of the cut surface by connective tissue with no breakdown of skeletal structures, or the beginning of dedifferentiation in the cartilage. However, the cells of the rudimentary blastema that forms do not undergo proliferation; instead they become separated from the epidermis by the regrowth of the connective tissue layer which acts as a block to regeneration. This condition, termed the critical stage, is reached more often by animals that received injections of hydrocortisone than by control animals. Experimental animals furthermore, produced larger blastemata. No advanced regeneration could be obtained however.

Systematic review of adjuvant therapy for early stage (epithelial) ovarian cancer

2003 ◽  
Vol 13 (4) ◽  
pp. 395-404 ◽  
Author(s):  
B. Winter-Roach ◽  
L. Hooper ◽  
H. Kitchener
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Adjuvant Chemotherapy ◽  
Adjuvant Therapy ◽  
Early Stage ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Significant Difference ◽  
Well Differentiated ◽  
Platinum Chemotherapy

A systematic review and meta analysis has been undertaken in order to evaluate the effectiveness of adjuvant therapy following surgery for early ovarian cancer. Trials reported since 1990 have been of a higher quality enabling a meta analysis of adjuvant chemotherapy vs adjuvant radiotherapy and a meta analysis of adjuvant chemotherapy vs observation. There was no significant difference between radiotherapy and chemotherapy, though these comprised studies which demonstrated considerable heterogeneity. Chemotherapy did confer significant benefit over observation in terms of both overall and disease free survival. Except for women in whom adequate surgical staging has revealed well differentiated disease confined to one or both ovaries with intact capsule, platinum chemotherapy should be offered to reduce risk of recurrence.

scholarly journals Retrospective analysis of Ca cervix postoperative: An institutional study

2016 ◽  
Author(s):  
Chandra Prakash
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Treatment Time ◽  
Residual Disease ◽  
Early Stage ◽  
Treatment Length ◽  
Recommended Treatment ◽  
Carcinoma Of Cervix ◽  
Well Differentiated

Introduction: Carcinoma of cervix is one of the leading causes of death worldwide and in developing countries like India. Cervical cancer is third most common cancer among women however there is a good chance of curability if diagnosed in early stage. Materials and Methods: We had analysed 78 patient of carcinoma of cervix post op who were registered from 2012 to 2015 at Dr. Ram Manohar Lohia Institute of Medical Sciences. Results: We analysed 78 patients between age of 32-70 years and median age is 50 year. Among all patients squamous cell carcinoma is most common (65 patient), adenocarcinoma were 12 and lieomyosarcoma was 1 patient. Among all patient 12 were of adenocarcinoma, 1 of lieomyosarcoma and 65 patient of squamous cell carcinoma. On examination 55 patients were NAD and 23 were residual. Among squamous cell carcinoma 35 were moderate differentiated, 18 were well differentiated and 12 were of poorly differentiated. On examination 55 patients were NAD rest were having disease. Gap between EBRT and SORBO ranging from 3 to 99 days and median is 27 days and median is 29 days. Treatment length varies from 4 cm to 8 cm and median is 6 cm. Ovoide size ranges from 2.5 cm to 3.5 cm and median is 2.5 cm. Dose per fraction ranges from 5 Gy to 9 Gy and median was 9 Gy. Median fraction of session were 2. Out of 78 patients 2 were developed metastasis and 6 having residual disease. 28 patients were NAD and rest were referral and send back to parent hospital. Conclusion: Due to lack of resources and awareness of disease maximum number of patient presented with advanced stage. The recommended treatment time could not be achieved due to scarcity of cancer centres, treatment time is prolonged. We have not found any relation between treatment length and outcome. We are still investigating to conclude to found out relation among these variables.

scholarly journals Giant Complex Odontoma of Mandible: A Spectacular Case Report

2017 ◽  
Vol 11 (1) ◽  
pp. 413-419 ◽  
Author(s):  
Narjiss Akerzoul ◽  
Saliha Chbicheb ◽  
Wafaa El Wady
Keyword(s):  
Case Report ◽  
Early Stage ◽  
Facial Asymmetry ◽  
Growth Potential ◽  
Benign Tumors ◽  
Large Size ◽  
General Dental Practitioner ◽  
Dental Practitioners ◽  
Complex Odontoma ◽  
Well Differentiated

Introduction: Odontomas are considered as benign tumors of odontogenic tissue origin and are more over non-aggressive. They can also be categorized as hamartomas and are a result of developmental malformation of odontogenic tissues. As the name suggests, they are composed of mature tooth substances. They possess limited and slow growth potential and are well differentiated. They can be ectodermal, mesodermal or mixed in origin. Mixed variety may be further divided into compound or complex depending upon their radio-graphical resemblance to the tooth. Compound odontomes are reported to be twice more common than complex odontomes. Among them, complex odontomes are asymptomatic unless they cause bony expansion of the jaws. Case Report: This paper aims to report and discuss a case of complex odontoma with unusually large size leading to gross facial asymmetry. Further this paper will highlight the important information the general dental practitioner must possess to diagnose such lesions at an early stage. Conclusion: Odontomas are benign odontogenic tumors with unusually large size leading to gross facial asymmetry. The general dental practitioners must possess the knowledge and important information to diagnose such lesions at an early stage.

scholarly journals Muscle and connective tissue progenitor populations show distinct Twist1 and Twist3 expression profiles during axolotl limb regeneration

2013 ◽  
Vol 373 (1) ◽  
pp. 196-204 ◽  
Author(s):  
Martin Kragl ◽  
Kathleen Roensch ◽  
Ina Nüsslein ◽  
Akira Tazaki ◽  
Yuka Taniguchi ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Expression Profiles ◽  
Limb Regeneration

scholarly journals Regenerative Polarity of the Fin Ray in Zebrafish Caudal Fin and Related Tissue Formation on the Cut Surface

2021 ◽  
Vol 9 (4) ◽  
pp. 50
Author(s):  
Wataru Nakajima ◽  
Soya Nakanishi ◽  
Ryosuke Hosoya ◽  
Toshiaki Uemoto ◽  
Shiro Ohgo ◽  
...  
Keyword(s):  
Early Stage ◽  
Distal Margin ◽  
Tissue Formation ◽  
Proximal Margin ◽  
Caudal Fin ◽  
Apical Side ◽  
Fin Ray ◽  
Fin Rays ◽  
Ability To Regenerate ◽  
Distal Edge

Zebrafish caudal fin rays are used as a model system for regeneration because of their high regenerative ability, but studies on the regeneration polarity of the fin ray are limited. To investigate this regeneration polarity, we made a hole to excise part of the fin ray and analyzed the regeneration process. We confirmed that the fin rays always regenerated from the proximal margin toward the distal margin, as previously reported; however, regeneration-related genes were expressed at both the proximal and distal edges of the hole in the early stage of regeneration, suggesting that the regenerative response also occurs at the distal edge. One difference between the proximal and distal margins is a sheet-like tissue that is formed on the apical side of the regenerated tissue at the proximal margin. This sheet-like tissue was not observed at the distal edge. To investigate whether the distal margin was also capable of forming this sheet-like tissue and subsequent regeneration, we kept the distal margin separated from the proximal margin by manipulation. Consequently, the sheet-like tissue was formed at the distal margin and regeneration of the fin ray was also induced. The regenerated fin rays from the distal margin protruded laterally from the caudal fin and then bent distally, and their ends showed the same characteristics as those of the normal fin rays. These results suggest that fin rays have an ability to regenerate in both directions; however, under normal conditions, regeneration is restricted to the proximal margin because the sheet-like tissue is preferentially formed on the apical side of the regenerating tissue from the proximal margin.

Histological considerations of the cleavage plane for preservation of facial and cochlear nerve functions in vestibular schwannoma surgery

2009 ◽  
Vol 110 (4) ◽  
pp. 648-655 ◽  
Author(s):  
Tomio Sasaki ◽  
Tadahisa Shono ◽  
Kimiaki Hashiguchi ◽  
Fumiaki Yoshida ◽  
Satoshi O. Suzuki
Keyword(s):  
Connective Tissue ◽  
Basic Protein ◽  
Cleavage Plane ◽  
Nerve Fibers ◽  
Vestibular Nerve ◽  
Cochlear Nerve ◽  
Tissue Layer ◽  
Connective Tissue Layer ◽  
Tumor Capsule ◽  
Tumor Parenchyma

Object The authors analyzed the tumor capsule and the tumor–nerve interface in vestibular schwannomas (VSs) to define the ideal cleavage plane for maximal tumor removal with preservation of facial and cochlear nerve functions. Methods Surgical specimens from 21 unilateral VSs were studied using classical H & E, Masson trichrome, and immunohistochemical staining against myelin basic protein. Results The authors observed a continuous thin connective tissue layer enveloping the surfaces of the tumors. Some nerve fibers, which were immunopositive to myelin basic protein and considered to be remnants of vestibular nerve fibers, were also identified widely beneath the connective tissue layer. These findings indicated that the socalled “tumor capsule” in VSs is the residual vestibular nerve tissue itself, consisting of the perineurium and underlying nerve fibers. There was no structure bordering the tumor parenchyma and the vestibular nerve fibers. In specimens of tumors removed en bloc with the cochlear nerves, the authors found that the connective tissue layer, corresponding to the perineurium of the cochlear nerve, clearly bordered the nerve fibers and tumor tissue. Conclusions Based on these histological observations, complete tumor resection can be achieved by removal of both tumor parenchyma and tumor capsule when a clear border between the tumor capsule and facial or cochlear nerve fibers can be identified intraoperatively. Conversely, when a severe adhesion between the tumor and facial or cochlear nerve fibers is observed, dissection of the vestibular nerve–tumor interface (the subcapsular or subperineurial dissection) is recommended for preservation of the functions of these cranial nerves.

scholarly journals Comparison among fertility-sparing therapies for well differentiated early-stage endometrial carcinoma and complex atypical hyperplasia

Oncotarget ◽  
2017 ◽  
Vol 8 (34) ◽  
pp. 57642-57653 ◽  
Author(s):  
Qing Zhang ◽  
Gonghua Qi ◽  
Margaux J. Kanis ◽  
Ruifen Dong ◽  
Baoxia Cui ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Early Stage ◽  
Atypical Hyperplasia ◽  
Fertility Sparing ◽  
Well Differentiated

Quantitative Ultrasound Imaging of Healthy and Reconstructed Cleft Lip: A Feasibility Study

2007 ◽  
Vol 44 (3) ◽  
pp. 261-268 ◽  
Author(s):  
Nancy J. M. van Hees ◽  
Johan M. Thijssen ◽  
Rinske W. Huyskens ◽  
Gert Weijers ◽  
Maartje M. Nillesen ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Cleft Lip ◽  
Scar Tissue ◽  
Noninvasive Evaluation ◽  
Central Position ◽  
Tissue Layer ◽  
Loose Connective Tissue ◽  
Connective Tissue Layer ◽  
Array Transducer ◽  
Orbicularis Oris Muscle

Objective: To investigate the feasibility of echographic imaging of healthy and reconstructed cleft lip and to estimate tissue dimensions and normalized echo level. Methods: Echographic images of the upper lip were made on three healthy subjects and two patients using a linear array transducer (7 to 11 MHz bandwidth) and a noncontact gel coupling. Tissue dimensions were measured using calipers. Echo levels were calibrated and were corrected for beam characteristics, gel path, and tissue attenuation using a tissue-mimicking phantom. Results: At the central position of the philtrum, mean thickness (SD) of lip loose connective tissue layer, orbicularis oris muscle, and dense connective layer was 4.0 (0.1) mm, 2.3 (0.7) mm, and 2.2 (0.7) mm, respectively, in healthy lip at rest; and 4.1 (0.9) mm, 3.8 (1.7) mm, and 2.6 (0.6) mm, respectively, in contracted lip. Mean (SD) echo level of muscle and dense connective tissue layer with respect to echo level of lip loose connective tissue layer was −19.3 (0.6) dB and −10.7 (4.0) dB, respectively, in relaxed condition and −20.7 (1.5) dB and −7.7 (2.3) dB, respectively, in contracted state. Color mode echo images were calculated, showing lip tissues in separate colors and highlighting details like discontinuity of the orbicularis oris muscle and presence of scar tissue. Conclusions: Quantitative assessment of thickness and echo level of various lip tissues is feasible after proper echographic equipment calibration. Diagnostic potentials of this method for noninvasive evaluation of cleft lip reconstruction outcome are promising.

The respiratory importance of vascularization of the tadpole operculum in Rana catesbeiana Shaw

1969 ◽  
Vol 47 (6) ◽  
pp. 1239-1243 ◽  
Author(s):  
Norman Gradwell
Keyword(s):  
Surface Area ◽  
Respiratory Function ◽  
Rana Catesbeiana ◽  
Bullfrog Tadpole ◽  
Anuran Tadpole ◽  
First Time ◽  
Arteries And Veins

Capillary densities in the opercular membrane of the bullfrog tadpole are consistent with the postulate that this membrane has the respiratory function of increasing the surface area for blood ventilation. The arteries and veins of the opercular membrane are mapped and identified for the first time in an anuran tadpole.

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