scholarly journals The people behind the papers – Dennis de Bakker, Mara Bouwman and Jeroen Bakkers

Development ◽  
2021 ◽  
Vol 148 (19) ◽  
Keyword(s):  
Transcription Factor ◽  
Therapeutic Potential ◽  
Medical Center ◽  
Heart Tissue ◽  
Group Leader ◽  
Adult Zebrafish ◽  
The People ◽  
The University ◽  
Zebrafish Heart

ABSTRACT Unlike mammals, adult zebrafish are capable of regenerating their hearts without scarring after injury – a process that has great therapeutic potential. A new paper in Development investigates the role of Prxx1b, a transcription factor that is expressed in epicardial heart tissue after injury, to understand its role in the scar-free regeneration of the adult zebrafish heart. To hear more about the study, we caught up with joint first authors, Dennis De Bakker and Mara Bouwman, and the corresponding author, Jeroen Bakkers, the group leader at the Hubrecht Institute and professor of Molecular Cardiogenetics at the University Medical Center in Utrecht, The Netherlands.

scholarly journals Inhibition of let-7c Regulates Cardiac Regeneration after Cryoinjury in Adult Zebrafish

2019 ◽  
Vol 6 (2) ◽  
pp. 16 ◽  
Author(s):  
Suneeta Narumanchi ◽  
Karri Kalervo ◽  
Sanni Perttunen ◽  
Hong Wang ◽  
Katariina Immonen ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Cardiac Regeneration ◽  
Nuclear Antigen ◽  
Heart Regeneration ◽  
Adult Zebrafish ◽  
Tissue Samples ◽  
Micro Rnas ◽  
Proliferating Cell ◽  
Zebrafish Heart

The let-7c family of micro-RNAs (miRNAs) is expressed during embryonic development and plays an important role in cell differentiation. We have investigated the role of let-7c in heart regeneration after injury in adult zebrafish. let-7c antagomir or scramble injections were given at one day after cryoinjury (1 dpi). Tissue samples were collected at 7 dpi, 14 dpi and 28 dpi and cardiac function was assessed before cryoinjury, 1 dpi, 7 dpi, 14 dpi and 28 dpi. Inhibition of let-7c increased the rate of fibrinolysis, increased the number of proliferating cell nuclear antigen (PCNA) positive cardiomyocytes at 7 dpi and increased the expression of the epicardial marker raldh2 at 7 dpi. Additionally, cardiac function measured with echocardiography recovered slightly more rapidly after inhibition of let-7c. These results reveal a beneficial role of let-7c inhibition in adult zebrafish heart regeneration.

scholarly journals “No me des el pescado, enséñame a pescar” “Do not hand me fish, teach me how to fish” Community Lawyering in Puerto Rico: Promoting empowerment and self-help

2014 ◽  
Vol 12 ◽  
pp. 83
Author(s):  
Myrta Morales-Cruz
Keyword(s):  
Community Development ◽  
Fish Community ◽  
Legal Aid ◽  
Self Help ◽  
Development Section ◽  
The People ◽  
The University ◽  
Insight Into ◽  
Special Meaning

<p>Law 232 of August 27, 2004 has a special meaning to the people residing in some of Puerto Rico's poorest communities. It was the result of the hard work, during a period of a year and a half, of leaders from some of these communities and my students, the students of the community development section of the Legal Aid Clinic of the University of Puerto Rico’s School of Law. The story of Law 232 can provide insight into what the role of a lawyer can be in the battle against poverty. To understand the story of this Puerto Rican law, one has to go back to August of 2002. During that month the University of Puerto Rico's School of Law Legal Aid Clinic inaugurated its community development section.</p>

Have we got ‘patient-centric sampling’ right?

Bioanalysis ◽  
2020 ◽  
Vol 12 (13) ◽  
pp. 869-872
Author(s):  
Remco A Koster
Keyword(s):  
Analytical Method ◽  
Method Development ◽  
Drugs Of Abuse ◽  
Medical Center ◽  
Dried Blood Spots ◽  
Health Sciences ◽  
The University ◽  
Development And Validation ◽  
Associate Director

RA Koster currently works as Associate Director of Bioanalytical Science at the LC–MS/MS department at PRA Health Sciences in the Laboratory in Assen, The Netherlands. He is responsible for the LC–MS/MS analytical method development and leads a team of method development analysts and scientists. As global microsampling specialist within PRA he is interested in all developments regarding microsampling and aims to continuously improve microsampling techniques. He has been working in the field of bioanalysis for 19 years, in which he performed and supervised numerous analytical method developments using LC–MS/MS. He started his career in 2001 at Pharma Bio-Research (before it was acquired by PRA) as an LC–MS/MS analyst. In 2005, he moved to the University Medical Center Groningen where he focused on the development and validation of analytical methods for drugs and drugs of abuse in matrices like blood, plasma, hair, saliva, dried blood spots and volumetric absorptive microsampling with LC–MS/MS. In 2015 he obtained his PhD on the subject ‘The influence of the sample matrix on LC–MS/MS method development and analytical performance’. In 2017, he started as Senior Scientist at PRA Health Sciences and in 2019, he accepted his current role of Associate Director of Bioanalytical Science. He is a (co-)author of more than 35 publications.

scholarly journals Synergy of Higher Education Collaboration with Local Governments in Efforts to Overcome the COVID-19 Pandemic

2021 ◽  
Vol 10 (2) ◽  
pp. 240-248
Author(s):  
. Karomani ◽  
. Mahpul ◽  
M. Iwan Satriawan
Keyword(s):  
Higher Education ◽  
Local Governments ◽  
Provincial Government ◽  
Mutual Support ◽  
Service Programs ◽  
The People ◽  
Community Service Programs ◽  
The Government ◽  
The University

The COVID-19 pandemic has had a serious impact on various aspects of Indonesia, especially the economy. The government has made countermeasures by issuing various policies and social programs. However, the implementation of policies is not necessarily followed by the attitude of the people who are not disciplined and indifferent. The role of higher education is very much needed to provide guidance with a humanist approach. Therefore, it is necessary to have a synergy of good cooperation between local governments and universities in facing obstacles in overcoming the COVID-19 pandemic. The research aims to analyze how the synergy between the government and universities is in overcoming the COVID-19 pandemic cases in the community. The research was conducted with a qualitative approach. The data were obtained through literature review and interviews with the Provincial Government of Lampung and the University of Lampung. The results of the study show that the synergy between the government and universities is good. This is shown by interaction and mutual support. Where the government acts as a policy maker and facilitator, while universities act as a support for implementation through community service programs.

scholarly journals First person – Victor Palacios

2021 ◽  
Vol 134 (7) ◽  
Keyword(s):  
Chromosome Segregation ◽  
Germ Cells ◽  
Medical Center ◽  
Early Career ◽  
First Person ◽  
University Of Texas ◽  
Early Career Researchers ◽  
The University ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Victor Palacios is first author on ‘Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells’, published in JCS. Victor conducted his PhD research in the lab of Michael Buszczak at the University of Texas Southwestern Medical Center, Dallas, TX, where he investigated the essential role of Importin-9 in Drosophila fertility.

scholarly journals Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Yunmei Wang ◽  
Huiyun Gao ◽  
Can Shi ◽  
Paul W. Erhardt ◽  
Alexander Pavlovsky ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Carotid Artery ◽  
Binding Site ◽  
Small Molecule ◽  
Therapeutic Potential ◽  
Bleeding Risk ◽  
Disease Models ◽  
Wild Type ◽  
Microvascular Injury

Abstract Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin αMβ2, or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbα is required for injury responses in diverse disease models. However, the role of Mac-1 in thrombosis is undefined. Here we report that mice with Mac-1 deficiency (Mac-1 −/− ) or mutation of the Mac-1-binding site for GPIbα have delayed thrombosis after carotid artery and cremaster microvascular injury without affecting parameters of haemostasis. Adoptive wild-type leukocyte transfer rescues the thrombosis defect in Mac-1 −/− mice, and Mac-1-dependent regulation of the transcription factor Foxp1 contributes to thrombosis as evidenced by delayed thrombosis in mice with monocyte-/macrophage-specific overexpression of Foxp1. Antibody and small-molecule targeting of Mac-1:GPIbα inhibits thrombosis. Our data identify a new pathway of thrombosis involving leukocyte Mac-1 and platelet GPIbα, and suggest that targeting this interaction has anti-thrombotic therapeutic potential with reduced bleeding risk.

scholarly journals Peran Dosen Fakultas Ekonomi dan Bisnis Universitas Teknologi Sumbawa dalam Peningkatan Literasi dan Inklusi Keuangan pada Masyarakat Kabupaten Sumbawa

2020 ◽  
Vol 10 (1) ◽  
pp. 33
Author(s):  
Abdul Salam ◽  
Abdurrahman Abdurrahman
Keyword(s):  
Financial Literacy ◽  
Positive Response ◽  
Public Awareness ◽  
Financial Inclusion ◽  
Added Value ◽  
The People ◽  
Strategic Location ◽  
The Right ◽  
The University

The purpose of this study was to identify the outcomes of higher education, in this case the University Technology of Sumbawa, because of its strategic location and positive response from the people of Sumbawa Regency, its ability to create added value and strategies for increasing public awareness of its financial future.The object of this research is the community in Sumbawa Regency with a sample size of 250 respondents. This study measures the role of Lecturers on, Financial Literacy and Inclusion.This study found that financial literacy partially affects the role of lecturers in being rejected. The financial inclusion variable has a significant effect on the role of the lecturer. Meanwhile, the variables of financial literacy and financial inclusion have a simultaneous effect on the role of lecturers.The conclusion of this research is in determining the right strategy to improve Financial Literacy and Financial Inclusion by increasing the role of Lecturers through Tri Dharma in order to create a well-lierate financial society

The Role of an African University

1971 ◽  
Vol 9 (1) ◽  
pp. 107-114 ◽  
Author(s):  
Julius K. Nyerere
Keyword(s):  
East Africa ◽  
Dar Es Salaam ◽  
Constituent Part ◽  
The People ◽  
University College ◽  
The University ◽  
Independent Existence

On the good foundation built by the University College of Dar es Salaam, which was a constituent part of the University of East Africa, we are now embarking upon our independent existence as a University. This is therefore an occasion for rejoicing. It is also an occasion which calls for re-dedication and renewed endeavour by all those involved. For it is now our responsibility to shape this institution so that it gives the maximum service to the people of Tanzania and their socialist objectives.

The Selection of Judges in Chicago, and the Rôle of the Local Bar Therein

1936 ◽  
Vol 30 (2) ◽  
pp. 315-323 ◽  
Author(s):  
Edward M. Martin
Keyword(s):  
Body Politic ◽  
The Body ◽  
Political Life ◽  
Judicial Selection ◽  
The Public ◽  
The People ◽  
Bar Association ◽  
The University ◽  
Democratic Procedure

For many years, the organized Bar has sought to guide the process of judicial selection. Its greatest activity has been in metropolitan communities where the choice is nominally by vote of the people. Such participation by a quasi-public group in a democratic procedure raises several pertinent questions. For example, what effect will it probably have on methods of selection now in force? Is such activity likely to become an accepted feature of our political life? Is such participation to be regarded as in the public interest? Is it a specific corrective that the body politic has developed to counterbalance too much democracy in judicial selection?To shed some light on these and related questions, the writer (as a graduate student at the University of Chicago) made a study of judicial selection in Chicago from 1870 to 1933, particular attention being given to the rôle of the Chicago Bar Association in the process.

scholarly journals RELEVANSI KEMAMPUAN ALUMNI PROGRAM STUDI TEKNIK SIPIL TERHADAP DUNIA KERJA

2016 ◽  
Vol 2 (2) ◽  
Author(s):  
Mahdi Mahdi
Keyword(s):  
Work Experience ◽  
Civil Engineering ◽  
Quality Of Work ◽  
Engineering Program ◽  
The People ◽  
The World ◽  
The Difference ◽  
The University

Competitive world of construction to create quality jobs in accordance with the wishes of the people are increasingly high, not only large contractors are trying as much as possible, medium and even small contractors will strive to improve the quality of work in accordance with the wishes of the people. This study aims to determine how relevant competence factors include knowledge, skills, and attitudes gained from the lectures of Civil Engineering University Almuslim with the needs in the world of work as well as knowing the difference of perception based on the role of the respondents (contractors and consultants) and work experience of respondents (under 4 year, 4 to 8 years, over 8 years). This research was conducted by distributing a questionnaire addressed to alumni of the University of Civil Engineering Program Almuslim that work to contractors and consultants who are directly involved in a construction project. Furthermore, all kuesoiner which were collected and analyzed statistically using the analysis Independent Sample T-test, and one way Analysis of Variance (ANOVA) using SPSS. From the analysis we found that the factor most relevant competences between the educational curriculum of Civil Engineering University Almuslim with the needs of the workforce total is "Reinforcement and Expenses Detail Bending, Axial, Slide, and Torque" on knowledge. For the skill aspect, the greatest subvariable is "Being able to become independent learners follow the development of science in civil engineering". For the aspects of attitude, the highest subvariable is "Experience". In addition, from the results of the analysis showed that there was no difference of perception based on the role and experience of the respondents.Keywords: Relevance, Capabilities, Competencies.

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