scholarly journals The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming

Development ◽  
2019 ◽  
Vol 146 (19) ◽  
pp. dev175950 ◽  
Author(s):  
Victor A. Ruthig ◽  
Matthew B. Friedersdorf ◽  
Jason A. Garness ◽  
Steve C. Munger ◽  
Corey Bunce ◽  
...  
Keyword(s):  
Germ Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Negative Regulator ◽  
Cell Reprogramming ◽  
Positive Regulator ◽  
Epigenetic Modifiers

RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours

2011 ◽  
Vol 59 (3) ◽  
pp. 452-459 ◽  
Author(s):  
Debin Xue ◽  
Yan Peng ◽  
Fenghua Wang ◽  
Robert W Allan ◽  
Dengfeng Cao
Keyword(s):  
Germ Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Germ Cell Tumours ◽  
Sensitive Marker

The RNA-binding protein Cpeb4 is a novel positive regulator of osteoclast differentiation

2020 ◽  
Vol 528 (4) ◽  
pp. 621-627
Author(s):  
Yasuhiro Arasaki ◽  
Masamichi Li ◽  
Takuro Akiya ◽  
Iori Nozawa ◽  
Yoichi Ezura ◽  
...  
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Osteoclast Differentiation ◽  
Rna Binding Protein ◽  
Positive Regulator

scholarly journals Dynamic regulation of immunity through post-translational control of defense transcript splicing

2019 ◽  
Author(s):  
Keini Dressano ◽  
Philipp R Weckwerth ◽  
Elly Poretsky ◽  
Yohei Takahashi ◽  
Carleen Villarreal ◽  
...  
Keyword(s):  
Immune Responses ◽  
Translational Control ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Negative Regulator ◽  
Signaling Proteins ◽  
Receptor Signaling ◽  
Post Translational Modification ◽  
Defense Signaling

AbstractSurvival of all living organisms requires the ability to detect attack and swiftly counter with protective immune responses. Despite considerable mechanistic advances, interconnectivity of signaling circuits often remains unclear. A newly-characterized protein, IMMUNOREGULATORY RNA-BINDING PROTEIN (IRR), negatively regulates immune responses in both maize and Arabidopsis, with disrupted function resulting in enhanced disease resistance. IRR physically interacts with, and promotes canonical splicing of, transcripts encoding defense signaling proteins, including the key negative regulator of pattern recognition receptor signaling complexes, CALCIUM-DEPENDENT PROTEIN KINASE 28 (CPK28). Upon immune activation by Plant Elicitor Peptides (Peps), IRR is dephosphorylated, disrupting interaction withCPK28transcripts and resulting in accumulation of an alternative splice variant encoding a truncated CPK28 protein with impaired kinase activity and diminished function as a negative regulator. We demonstrate a novel circuit linking Pep-induced post-translational modification of IRR with post-transcriptionally-mediated attenuation of CPK28 function to dynamically amplify Pep signaling and immune output.One Sentence SummaryPlant innate immunity is promoted by post-translational modification of a novel RNA-binding protein that regulates alternative splicing of transcripts encoding defense signaling proteins to dynamically increase immune receptor signaling capacity through deactivation of a key signal-buffering circuit.

scholarly journals Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse

2008 ◽  
Vol 17 (18) ◽  
pp. 2803-2818 ◽  
Author(s):  
Ingrid Ehrmann ◽  
Caroline Dalgliesh ◽  
Aikaterini Tsaousi ◽  
Maria Paola Paronetto ◽  
Bettina Heinrich ◽  
...  
Keyword(s):  
Germ Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Nuclear Rna

scholarly journals RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases

2010 ◽  
Vol 24 (2) ◽  
pp. 288-296 ◽  
Author(s):  
Dengfeng Cao ◽  
Aijun Liu ◽  
Fenghua Wang ◽  
Robert W Allan ◽  
Kaiyong Mei ◽  
...  
Keyword(s):  
Germ Cell ◽  
Rna Binding ◽  
Immunohistochemical Study ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Germ Cell Tumors ◽  
Extragonadal Germ Cell Tumors

scholarly journals The RNA-binding protein XSeb4R: a positive regulator of VegT mRNA stability and translation that is required for germ layer formation in Xenopus

2008 ◽  
Vol 22 (17) ◽  
pp. 2347-2352 ◽  
Author(s):  
J. Souopgui ◽  
B. Rust, ◽  
J. Vanhomwegen ◽  
J. Heasman ◽  
K. A. Henningfeld ◽  
...  
Keyword(s):  
Mrna Stability ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Germ Layer ◽  
Layer Formation ◽  
Positive Regulator ◽  
Germ Layer Formation

scholarly journals Male Germ Cell-Specific RNA Binding Protein RBMY: A New Oncogene Explaining Male Predominance in Liver Cancer

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e26948 ◽  
Author(s):  
Daw-Jen Tsuei ◽  
Po-Huang Lee ◽  
Hsiao-Yu Peng ◽  
Shau-Lin Lu ◽  
De-Shiuan Su ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Germ Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Male Germ Cell ◽  
Male Predominance

scholarly journals Author response: An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning

2018 ◽  
Author(s):  
Ingrid Ehrmann ◽  
James H Crichton ◽  
Matthew R Gazzara ◽  
Katherine James ◽  
Yilei Liu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Splice Site ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Author Response ◽  
Cryptic Splice Site

RNA binding protein Musashi‐1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus

2015 ◽  
Vol 29 (7) ◽  
pp. 2759-2768 ◽  
Author(s):  
Jessie M. Sutherland ◽  
Alexander P. Sobinoff ◽  
Barbara A. Fraser ◽  
Kate A. Redgrove ◽  
Tara‐Lynne Davidson ◽  
...  
Keyword(s):  
Germ Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cell Development ◽  
Germ Cell Development
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