scholarly journals Trithorax regulates systemic signaling duringDrosophilaimaginal disc regeneration

Development ◽  
2015 ◽  
Vol 142 (20) ◽  
pp. 3500-3511 ◽  
Author(s):  
Andrea Skinner ◽  
Sumbul Jawed Khan ◽  
Rachel K. Smith-Bolton
Keyword(s):  
Disc Regeneration ◽  
Systemic Signaling

scholarly journals Investigating the Possibility of Intervertebral Disc Regeneration Induced by Granulocyte Colony Stimulating Factor-Stimulated Stem Cells in Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Wen-Ching Tzaan ◽  
Hsien-Chih Chen
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Intervertebral Disc ◽  
Bone Marrow Stem Cells ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Hematopoietic Stem ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration ◽  
Stimulating Factor

Intervertebral disc (IVD) degeneration is a multifactorial process that is influenced by contributions from genetic predisposition, the aging phenomenon, lifestyle conditions, biomechanical loading and activities, and other health factors (such as diabetes). Attempts to decelerate disc degeneration using various techniques have been reported. However, to date, there has been no proven technique effective for broad clinical application. Granulocyte colony-stimulating factor (GCSF) is a growth factor cytokine that has been shown to enhance the availability of circulating hematopoietic stem cells to the brain and heart as well as their capacity for mobilization of mesenchymal bone marrow stem cells. GCSF also exerts significant increases in circulating neutrophils as well as potent anti-inflammatory effects. In our study, we hypothesize that GCSF can induce bone marrow stem cells differentiation and mobilization to regenerate the degenerated IVD. We found that GCSF had no contribution in disc regeneration or maintenance; however, there were cell proliferation within end plates. The effects of GCSF treatment on end plates might deserve further investigation.

Integration of local and systemic signaling pathways for plant N responses

2012 ◽  
Vol 15 (2) ◽  
pp. 185-191 ◽  
Author(s):  
José M Alvarez ◽  
Elena A Vidal ◽  
Rodrigo A Gutiérrez
Keyword(s):  
Signaling Pathways ◽  
Systemic Signaling

Systemic control of nodule formation by the plant N demand requires autoregulation dependent and independent mechanisms

2021 ◽  
Author(s):  
Marjorie Pervent ◽  
Ilana Lambert ◽  
Marc Tauzin ◽  
Alicia Karouani ◽  
Martha Nigg ◽  
...  
Keyword(s):  
Nitrogen Fixation ◽  
Nodule Formation ◽  
Atmospheric Nitrogen ◽  
Plant Nitrogen ◽  
Systemic Signaling ◽  
Systemic Control ◽  
Whole Plant ◽  
Strong Control ◽  
Mutant Genes ◽  
N Demand

Abstract In legumes interacting with rhizobia the formation of symbiotic organs involved in the acquisition of atmospheric nitrogen is depending of the plant nitrogen (N) demand. We used Medicago truncatula plants cultivated in split-root systems to discriminate between responses to local and systemic N signalings. We evidenced a strong control of nodule formation by systemic N-signaling but obtained no clear evidence of a local control by mineral nitrogen. Systemic signaling of the plant N demand controls numerous transcripts involved in the root transcriptome reprogramming associated to early rhizobia interaction and nodule formation. SUNN has an important role in this control but major systemic N signaling responses remained active in the sunn mutant. Genes involved in the activation of nitrogen fixation are regulated by systemic N signaling in the mutant, explaining why the hypernodulation phenotype is not associated to a higher nitrogen fixation of the whole plant. The control of the transcriptome reprogramming of nodule formation by systemic N signaling requires other pathway(s) that parallel the SUNN/CLE pathway.

scholarly journals CD24 identifies nucleus pulposus progenitors/notochordal cells for disc regeneration

2018 ◽  
Vol 12 (1) ◽  
Author(s):  
Zhuochao Liu ◽  
Zhiyong Zheng ◽  
Jin Qi ◽  
Jun Wang ◽  
Qi Zhou ◽  
...  
Keyword(s):  
Nucleus Pulposus ◽  
Notochordal Cells ◽  
Disc Regeneration

scholarly journals Stem cells in intervertebral disc regeneration–more talk than action?

BIOCELL ◽  
2022 ◽  
Vol 46 (4) ◽  
pp. 893-898
Author(s):  
PETRA KRAUS ◽  
ANKITA SAMANTA ◽  
SINA LUFKIN ◽  
THOMAS LUFKIN
Keyword(s):  
Stem Cells ◽  
Intervertebral Disc ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration
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