scholarly journals Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds

Development ◽  
1996 ◽  
Vol 122 (4) ◽  
pp. 1147-1155 ◽  
Author(s):  
K. Patel ◽  
R. Nittenberg ◽  
D. D'Souza ◽  
C. Irving ◽  
D. Burt ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Limb Development ◽  
Cell Signalling ◽  
Limb Patterning ◽  
Kinase Gene ◽  
Limb Buds ◽  
Tyrosine Kinase Gene ◽  
A Cell ◽  
Receptor Tyrosine Kinase Gene

The Eph-related receptor tyrosine kinase gene, Cek-8, is expressed in mesenchyme at the tip of chick limb buds, with high levels of transcripts posteriorly and apically but fading out anteriorly. Expression of Cek-8 in distal mesenchyme is regulated by apical ridge- and FGF-polarising signals and retinoic acid, and is uniform across the anteroposterior axis in talpid3 mutants. These data indicate that Cek-8 expression responds to regulatory signals during limb patterning and suggest that this receptor tyrosine kinase may have a role in coordinating responses to signals in the progress zone of early buds. Later on in limb development, Cek-8 expression is associated with cell condensations that form tendons and their attachments to cartilage rudiments and then in developing feather buds.

scholarly journals Distinct Mutations in the Receptor Tyrosine Kinase Gene ROR2 Cause Brachydactyly Type B

2000 ◽  
Vol 67 (4) ◽  
pp. 822-831 ◽  
Author(s):  
Georg C. Schwabe ◽  
Sigrid Tinschert ◽  
Christian Buschow ◽  
Peter Meinecke ◽  
Gerhard Wolff ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Type B ◽  
Kinase Gene ◽  
Tyrosine Kinase Gene ◽  
Receptor Tyrosine Kinase Gene

FLT4 Receptor Tyrosine Kinase Gene Mapping to Chromosome Band 5q35 in Relation to the t(2;5), t(5;6), and t(3;5) Translocations

1993 ◽  
Vol 7 (3) ◽  
pp. 144-151 ◽  
Author(s):  
Elina Armstrong ◽  
Kumar Kastury ◽  
Olga Aprelikova ◽  
Florencia Bullrich ◽  
Christian Nezelof ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Gene Mapping ◽  
Receptor Tyrosine Kinase ◽  
Chromosome Band ◽  
Kinase Gene ◽  
Tyrosine Kinase Gene ◽  
Receptor Tyrosine Kinase Gene

scholarly journals Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction.

Genetics ◽  
1991 ◽  
Vol 128 (2) ◽  
pp. 251-267 ◽  
Author(s):  
R V Aroian ◽  
P W Sternberg
Keyword(s):  
Caenorhabditis Elegans ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Egf Receptor ◽  
Kinase Gene ◽  
Multiple Functions ◽  
Tyrosine Kinase Gene ◽  
Receptor Tyrosine Kinase Gene ◽  
Epidermal Growth ◽  
Mutant Phenotypes

Abstract The let-23 gene, which encodes a putative tyrosine kinase of the epidermal growth factor (EGF) receptor subfamily, has multiple functions during Caenorhabditis elegans development. We show that let-23 function is required for vulval precursor cells (VPCs) to respond to the signal that induces vulval differentiation: a complete loss of let-23 function results in no induction. However, some let-23 mutations that genetically reduce but do not eliminate let-23 function result in VPCs apparently hypersensitive to inductive signal: as many as five of six VPCs can adopt vulval fates, in contrast to the three that normally do. These results suggest that the let-23 receptor tyrosine kinase controls two opposing pathways, one that stimulates vulval differentiation and another that negatively regulates vulval differentiation. Furthermore, analysis of 16 new let-23 mutations indicates that the let-23 kinase functions in at least five tissues. Since various let-23 mutant phenotypes can be obtained independently, the let-23 gene is likely to have tissue-specific functions.

scholarly journals The receptor tyrosine kinase gene linotte is required for neuronal pathway selection in the Drosophila mushroom bodies

1998 ◽  
Vol 78 (1-2) ◽  
pp. 47-61 ◽  
Author(s):  
Caroline Moreau-Fauvarque ◽  
Emmanuel Taillebourg ◽  
Elisabeth Boissoneau ◽  
Jacqueline Mesnard ◽  
Jean-Maurice Dura
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Mushroom Bodies ◽  
Kinase Gene ◽  
Neuronal Pathway ◽  
Tyrosine Kinase Gene ◽  
Receptor Tyrosine Kinase Gene

Genomic Structure and Promoter Analysis of the Mouse EphA8 Receptor Tyrosine Kinase Gene

2000 ◽  
Vol 19 (5) ◽  
pp. 291-300 ◽  
Author(s):  
Jaemin Jeong ◽  
Sunga Choi ◽  
Changkyu Gu ◽  
Hansoo Lee ◽  
Soochul Park
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Promoter Analysis ◽  
Genomic Structure ◽  
Kinase Gene ◽  
Tyrosine Kinase Gene ◽  
Receptor Tyrosine Kinase Gene

scholarly journals The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor

1999 ◽  
Vol 96 (19) ◽  
pp. 10869-10874 ◽  
Author(s):  
J. K. Doherty ◽  
C. Bond ◽  
A. Jardim ◽  
J. P. Adelman ◽  
G. M. Clinton
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Kinase Gene ◽  
Tyrosine Kinase Gene ◽  
Receptor Tyrosine Kinase Gene ◽  
Her 2
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