scholarly journals glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis

Development ◽  
2015 ◽  
Vol 142 (8) ◽  
pp. 1407-1417 ◽  
Author(s):  
L. Ye ◽  
M. A. Robertson ◽  
D. Hesselson ◽  
D. Y. R. Stainier ◽  
R. M. Anderson
Keyword(s):  
Beta Cell ◽  
Alpha Cell ◽  
Cell Transdifferentiation ◽  
Beta Cell Neogenesis

scholarly journals Liraglutide and sitagliptin counter beta- to alpha-cell transdifferentiation in diabetes

2020 ◽  
Vol 245 (1) ◽  
pp. 53-64 ◽  
Author(s):  
Neil Tanday ◽  
Peter R Flatt ◽  
Nigel Irwin ◽  
R Charlotte Moffett
Keyword(s):  
Insulin Resistance ◽  
Beta Cell ◽  
Beta Cells ◽  
Lineage Tracing ◽  
Alpha Cell ◽  
Beta Cell Destruction ◽  
Glucose Levels ◽  
Cell Destruction ◽  
Cell Transdifferentiation ◽  
The Impact

Transdifferentiation of beta- to alpha-cells has been implicated in the pathogenesis of diabetes. To investigate the impact of contrasting aetiologies of beta-cell stress, as well as clinically approved incretin therapies on this process, lineage tracing of beta-cells in transgenic Ins1 Cre/+/Rosa26-eYFP mice was investigated. Diabetes-like syndromes were induced by streptozotocin (STZ), high fat feeding (HFF) or hydrocortisone (HC), and effects of treatment with liraglutide or sitagliptin were investigated. Mice developed the characteristic metabolic features associated with beta-cell destruction or development of insulin resistance. Liraglutide was effective in preventing weight gain in HFF mice, with both treatments decreasing energy intake in STZ and HC mice. Treatment intervention also significantly reduced blood glucose levels in STZ and HC mice, as well as increasing either plasma or pancreatic insulin while decreasing circulating or pancreatic glucagon in all models. The recognised changes in pancreatic morphology induced by STZ, HFF or HC were partially, or fully, reversed by liraglutide and sitagliptin, and related to advantageous effects on alpha- and beta-cell growth and survival. More interestingly, induction of diabetes-like phenotype, regardless of pathogenesis, led to increased numbers of beta-cells losing their identity, as well as decreased expression of Pdx1 within beta-cells. Both treatment interventions, and especially liraglutide, countered detrimental islet cell transitioning effects in STZ and HFF mice. Only liraglutide imparted benefits on beta- to alpha-cell transdifferentiation in HC mice. These data demonstrate that beta- to alpha-cell transdifferentiation is a common consequence of beta-cell destruction or insulin resistance and that clinically approved incretin-based drugs effectively limit this.

scholarly journals .BETA. Cell Neogenesis from Ducts and Phenotypic Conversion of Residual Islet Cells in the Adult Pancreas of Glucose Intolerant Mice Induced by Selective Alloxan Perfusion.

2002 ◽  
Vol 49 (5) ◽  
pp. 561-572 ◽  
Author(s):  
MING LI ◽  
JUN-ICHIRO MIYAGAWA ◽  
KOJI YAMAMOTO ◽  
MAKOTO MORIWAKI ◽  
AKIHISA IMAGAWA ◽  
...  
Keyword(s):  
Beta Cell ◽  
Islet Cells ◽  
Beta Cell Neogenesis

Beta-cell neogenesis in type 2 diabetes

Diabetes ◽  
2001 ◽  
Vol 50 (Supplement 1) ◽  
pp. S186-S187 ◽  
Author(s):  
L. C. Jones ◽  
A. Clark
Keyword(s):  
Type 2 Diabetes ◽  
Beta Cell ◽  
Beta Cell Neogenesis

scholarly journals Pancreatic acinar-to-beta cell transdifferentiation in vitro

10.2741/3119 ◽  
2008 ◽  
Vol Volume (13) ◽  
pp. 5824 ◽  
Author(s):  
Kohtaro Minami
Keyword(s):  
Beta Cell ◽  
Cell Transdifferentiation
Sign in / Sign up

Export Citation Format

Share Document