scholarly journals The serpin PN1 is a feedback regulator of FGF signaling in germ layer and primary axis formation

Development ◽  
2015 ◽  
Vol 142 (6) ◽  
pp. 1146-1158 ◽  
Author(s):  
H. Acosta ◽  
D. Iliev ◽  
T. H. M. Grahn ◽  
N. Gouignard ◽  
M. Maccarana ◽  
...  
Keyword(s):  
Axis Formation ◽  
Germ Layer ◽  
Fgf Signaling ◽  
Primary Axis ◽  
Feedback Regulator

Diversity of germ layer and axis formation among mammals

2004 ◽  
Vol 15 (5) ◽  
pp. 619-629 ◽  
Author(s):  
Guy S Eakin ◽  
Richard R Behringer
Keyword(s):  
Axis Formation ◽  
Germ Layer

scholarly journals Axis formation in annual killifish: Nodal coordinates morphogenesis in absence of Huluwa prepatterning

2021 ◽  
Author(s):  
Philip Abitua ◽  
Deniz Aksel ◽  
Alexander Schier
Keyword(s):  
Break Symmetry ◽  
Axis Formation ◽  
Germ Layer ◽  
Gene Products ◽  
Aggregation Process ◽  
Nodal Signaling ◽  
Annual Killifish ◽  
Nothobranchius Furzeri ◽  
Nodal Coordinates ◽  
Maternal Gene

Axis formation in fish and amphibians is initiated by a prepattern of maternal gene products in the blastula. The embryogenesis of annual killifish challenges prepatterning models because blastomeres disperse and then re-aggregate to form the germ layers and body axes. This dispersion-aggregation process prompts the question how axis determinants such as Huluwa and germ layer inducers such as Nodal function in annual killifish. Here we show in Nothobranchius furzeri that huluwa, the factor thought to break symmetry by stabilizing β-catenin, is a non-functional pseudogene. Nuclear β-catenin is not selectively stabilized on one side of the blastula but accumulates in cells forming the incipient aggregate. Inhibition of Nodal signaling blocks aggregation and disrupts coordinated cell migration, establishing a novel role for this signaling pathway. These results reveal a surprising departure from classic mechanisms of axis formation: canonical Huluwa-mediated prepatterning is dispensable and Nodal coordinates morphogenesis.

scholarly journals BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Richard H Row ◽  
Amy Pegg ◽  
Brian A Kinney ◽  
Gist H Farr ◽  
Lisa Maves ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Bhlh Transcription Factor ◽  
Germ Layer ◽  
Transcription Factor Activity ◽  
Fgf Signaling ◽  
Factor Activity ◽  
Cell Fates ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix ◽  
Bhlh Transcription Factors

The mesodermal germ layer is patterned into mediolateral subtypes by signaling factors including BMP and FGF. How these pathways are integrated to induce specific mediolateral cell fates is not well understood. We used mesoderm derived from post-gastrulation neuromesodermal progenitors (NMPs), which undergo a binary mediolateral patterning decision, as a simplified model to understand how FGF acts together with BMP to impart mediolateral fate. Using zebrafish and mouse NMPs, we identify an evolutionarily conserved mechanism of BMP and FGF-mediated mediolateral mesodermal patterning that occurs through modulation of basic helix-loop-helix (bHLH) transcription factor activity. BMP imparts lateral fate through induction of Id helix loop helix (HLH) proteins, which antagonize bHLH transcription factors, induced by FGF signaling, that specify medial fate. We extend our analysis of zebrafish development to show that bHLH activity is responsible for the mediolateral patterning of the entire mesodermal germ layer.

scholarly journals A dual function of FGF signaling in Xenopus left-right axis formation

Development ◽  
2019 ◽  
Vol 146 (9) ◽  
pp. dev173575 ◽  
Author(s):  
Isabelle Schneider ◽  
Jennifer Kreis ◽  
Axel Schweickert ◽  
Martin Blum ◽  
Philipp Vick
Keyword(s):  
Dual Function ◽  
Axis Formation ◽  
Fgf Signaling

Epilogy, germ layer and axis formation in Brachydanuio (Zebraafish)

1989 ◽  
Vol 27 ◽  
pp. 216
Author(s):  
R. Fleig ◽  
H. Vollmar ◽  
K. Sander
Keyword(s):  
Axis Formation ◽  
Germ Layer

scholarly journals Identification of a retinoic acid-sensitive period during primary axis formation in Xenopus laevis.

1990 ◽  
Vol 4 (6) ◽  
pp. 932-942 ◽  
Author(s):  
H L Sive ◽  
B W Draper ◽  
R M Harland ◽  
H Weintraub
Keyword(s):  
Retinoic Acid ◽  
Xenopus Laevis ◽  
Sensitive Period ◽  
Axis Formation ◽  
Primary Axis
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