scholarly journals Notch/Rbpj  signaling regulates progenitor maintenance and differentiation of hypothalamic arcuate neurons

Development ◽  
2013 ◽  
Vol 140 (17) ◽  
pp. 3511-3521 ◽  
Author(s):  
P. K. Aujla ◽  
G. T. Naratadam ◽  
L. Xu ◽  
L. T. Raetzman
Keyword(s):  
Progenitor Maintenance ◽  
Arcuate Neurons

Decreased inhibition by leptin of hypothalamic arcuate neurons in neonatally overfed young rats

Neuroreport ◽  
2000 ◽  
Vol 11 (12) ◽  
pp. 2795-2798 ◽  
Author(s):  
Helga Davidowa ◽  
Andreas Plagemann
Keyword(s):  
Young Rats ◽  
Arcuate Neurons

Insulin resistance of hypothalamic arcuate neurons in neonatally overfed rats

Neuroreport ◽  
2007 ◽  
Vol 18 (5) ◽  
pp. 521-524 ◽  
Author(s):  
Helga Davidowa ◽  
Andreas Plagemann
Keyword(s):  
Insulin Resistance ◽  
Arcuate Neurons

scholarly journals Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis

PLoS Biology ◽  
2010 ◽  
Vol 8 (8) ◽  
pp. e1000460 ◽  
Author(s):  
Alfonso Lavado ◽  
Oleg V. Lagutin ◽  
Lionel M. L. Chow ◽  
Suzanne J. Baker ◽  
Guillermo Oliver
Keyword(s):  
Granule Cell ◽  
Cell Maturation ◽  
Progenitor Maintenance

scholarly journals Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Bama Charan Mondal ◽  
Jiwon Shim ◽  
Cory J Evans ◽  
Utpal Banerjee
Keyword(s):  
Drosophila Melanogaster ◽  
Blood Cells ◽  
Lymph Gland ◽  
Genetic Screen ◽  
Signal Control ◽  
Vegf Receptor ◽  
Interacting Protein ◽  
Hematopoietic Development ◽  
New Genes ◽  
Progenitor Maintenance

Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells. We term the signal from differentiating cells the ‘equilibrium signal’ in order to distinguish it from the ‘niche signal’. Earlier we showed that equilibrium signaling utilizes Pvr (the Drosophila PDGF/VEGF receptor), STAT92E, and adenosine deaminase-related growth factor A (ADGF-A) (<xref ref-type="bibr" rid="bib43">Mondal et al., 2011</xref>). Little is known about how this signal initiates during hematopoietic development. To identify new genes involved in lymph gland blood progenitor maintenance, particularly those involved in equilibrium signaling, we performed a genetic screen that identified bip1 (bric à brac interacting protein 1) and Nucleoporin 98 (Nup98) as additional regulators of the equilibrium signal. We show that the products of these genes along with the Bip1-interacting protein RpS8 (Ribosomal protein S8) are required for the proper expression of Pvr.

scholarly journals Omics profiling identifies MAPK/ERK pathway as a gatekeeper of nephron progenitor metabolism

2021 ◽  
Author(s):  
Hyuk Nam Kwon ◽  
Kristen Kurtzeborn ◽  
Xing Jin ◽  
Bruno Reversade ◽  
Sunghyouk Park ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Mitogen Activated Protein Kinase ◽  
Metabolic Effects ◽  
Erk Pathway ◽  
Double Knockout ◽  
Nephron Progenitor ◽  
Progenitor Maintenance

Nephron endowment is defined by fetal kidney growth and it critically dictates renal health in adults. Despite the advances in understanding the molecular regulation of nephron progenitor maintenance, propagation, and differentiation, the causes for low congenital nephron count and contribution of basic metabolism to nephron progenitor regulation remain poorly studied. Here we have analyzed the metabolic effects that depend on and are triggered by the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway, which is an essential intracellular cascade required for nephron progenitor maintenance. Our combined approach utilizing LC/MS-based metabolomics and transcriptional profiling of MAPK/ERK-deficient cells identified 18 out of total 46 metabolites (38 untargeted and 8 targeted) that were down-regulated. These represent glycolysis, gluconeogenesis, pentose phosphate, glycine, and proline pathways among others. We focused our functional characterization of identified metabolites on pyruvate and proline. Use of in vitro kidney cultures revealed dosage-specific functions for pyruvate in not only controlling ureteric bud branching but also determining progenitor and differentiated (tip-trunk) cell identities. Our in vivo characterization of Pycr1/2 double knockout kidneys revealed functional requirement for proline metabolism in nephron progenitor maintenance. In summary, our results demonstrate that MAPK/ERK cascade regulates energy and amino acid metabolism in developing kidney where these metabolic pathways specifically regulate progenitor preservation.

Single-Unit Activity of Hypothalamic Arcuate Neurons in Brain Tissue Slices

1986 ◽  
Vol 43 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Jenn-Tser Pan ◽  
Lee-Ming Kow ◽  
Donald W. Pfaff
Keyword(s):  
Brain Tissue ◽  
Unit Activity ◽  
Single Unit ◽  
Single Unit Activity ◽  
Tissue Slices ◽  
Arcuate Neurons
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