scholarly journals Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis

Development ◽  
2013 ◽  
Vol 140 (11) ◽  
pp. 2299-2309 ◽  
Author(s):  
M.-O. Trowe ◽  
L. Zhao ◽  
A.-C. Weiss ◽  
V. Christoffels ◽  
D. J. Epstein ◽  
...  
Keyword(s):  
Ventral Diencephalon

FGF3 from the Hypothalamus Regulates the Guidance of Thalamocortical Axons

2020 ◽  
Vol 42 (5-6) ◽  
pp. 208-216
Author(s):  
Kuan Liu ◽  
Zhongsheng Lv ◽  
Hong Huang ◽  
Shuyang Yu ◽  
Li Xiao ◽  
...  
Keyword(s):  
Sensory Information ◽  
Axonal Pathfinding ◽  
Fibroblast Growth ◽  
High Concentration ◽  
Dependent Effect ◽  
Development Stages ◽  
Guidance Cues ◽  
Thalamocortical Axons ◽  
Ventral Diencephalon

Thalamus is an important sensory relay station: afferent sensory information, except olfactory signals, is transmitted by thalamocortical axons (TCAs) to the cerebral cortex. The pathway choice of TCAs depends on diverse diffusible or substrate-bound guidance cues in the environment. Not only classical guidance cues (ephrins, slits, semaphorins, and netrins), morphogens, which exerts patterning effects during early embryonic development, can also help axons navigate to their targets at later development stages. Here, expression analyses reveal that morphogen Fibroblast growth factor (FGF)-3 is expressed in the chick ventral diencephalon, hypothalamus, during the pathfinding of TCAs. Then, using in vitro analyses in chick explants, we identify a concentration-dependent effect of FGF3 on thalamic axons: attractant 100 ng/mL FGF3 transforms to a repellent at high concentration 500 ng/mL. Moreover, inhibition of FGF3 guidance functions indicates that FGF3 signaling is necessary for the correct navigation of thalamic axons. Together, these studies demonstrate a direct effect for the member of FGF7 subfamily, FGF3, in the axonal pathfinding of TCAs.

scholarly journals Wnt genes affect patterning of the ventral diencephalon and pituitary gland growth

2006 ◽  
Vol 295 (1) ◽  
pp. 456
Author(s):  
Mary A. Potok ◽  
Kelly B. Cha ◽  
Andrea Hunt ◽  
Michelle L. Brinkmeier ◽  
Andreas Kispert ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Ventral Diencephalon

Hypocretin/orexin-containing neurons are produced in one sharp peak in the developing ventral diencephalon

2005 ◽  
Vol 22 (2) ◽  
pp. 531-534 ◽  
Author(s):  
C. Amiot ◽  
F. Brischoux ◽  
C. Colard ◽  
A. La Roche ◽  
D. Fellmann ◽  
...  
Keyword(s):  
Sharp Peak ◽  
Ventral Diencephalon

Modeling Parkinson’s Disease in Zebrafish

2020 ◽  
Vol 19 (5) ◽  
pp. 386-399
Author(s):  
Nor H.M. Najib ◽  
Yong H. Nies ◽  
Syarifah A.S. Abd Halim ◽  
Mohamad F. Yahaya ◽  
Srijit Das ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Treatment Strategies ◽  
Mammalian Brain ◽  
Mechanistic Study ◽  
Research Model ◽  
True Nature ◽  
Therapeutic Compounds ◽  
And Control ◽  
Ventral Diencephalon

Parkinson’s Disease (PD) is one of the most common neurodegenerative disorders that affects the motor system, and includes cardinal motor symptoms such as resting tremor, cogwheel rigidity, bradykinesia and postural instability. Its prevalence is increasing worldwide due to the increase in life span. Although, two centuries since the first description of the disease, no proper cure with regard to treatment strategies and control of symptoms could be reached. One of the major challenges faced by the researchers is to have a suitable research model. Rodents are the most common PD models used, but no single model can replicate the true nature of PD. In this review, we aim to discuss another animal model, the zebrafish (Danio rerio), which is gaining popularity. Zebrafish brain has all the major structures found in the mammalian brain, with neurotransmitter systems, and it also possesses a functional blood-brain barrier similar to humans. From the perspective of PD research, the zebrafish possesses the ventral diencephalon, which is thought to be homologous to the mammalian substantia nigra. We summarize the various zebrafish models available to study PD, namely chemical-induced and genetic models. The zebrafish can complement the use of other animal models for the mechanistic study of PD and help in the screening of new potential therapeutic compounds.

scholarly journals Genetic regulation of murine pituitary development

2015 ◽  
Vol 54 (2) ◽  
pp. R55-R73 ◽  
Author(s):  
Karine Rizzoti
Keyword(s):  
Endocrine Cells ◽  
Molecular Mechanisms ◽  
Genetic Regulation ◽  
Three Dimensional ◽  
Significant Progress ◽  
Pituitary Development ◽  
Tumour Formation ◽  
Ventral Diencephalon

Significant progress has been made recently in unravelling the embryonic events leading to pituitary morphogenesis, bothin vivoandin vitro. This includes dissection of the molecular mechanisms controlling patterning of the ventral diencephalon that regulate formation of the pituitary anlagen or Rathke's pouch. There is also a better characterisation of processes that underlie maintenance of pituitary progenitors, specification of endocrine lineages and the three-dimensional organisation of newly differentiated endocrine cells. Furthermore, a population of adult pituitary stem cells (SCs), originating from embryonic progenitors, have been described and shown to have not only regenerative potential, but also the capacity to induce tumour formation. Finally, the successful recapitulationin vitroof embryonic events leading to generation of endocrine cells from embryonic SCs, and their subsequent transplantation, represents exciting advances towards the use of regenerative medicine to treat endocrine deficits. In this review, an up-to-date description of pituitary morphogenesis will be provided and discussed with particular reference to pituitary SC studies.

Transgenic zebrafish expressing green fluorescent protein in dopaminergic neurons of the ventral diencephalon

2011 ◽  
Vol 240 (11) ◽  
pp. 2539-2547 ◽  
Author(s):  
Yanwei Xi ◽  
Man Yu ◽  
Rafael Godoy ◽  
Gary Hatch ◽  
Luc Poitras ◽  
...  
Keyword(s):  
Green Fluorescent Protein ◽  
Dopaminergic Neurons ◽  
Fluorescent Protein ◽  
Transgenic Zebrafish ◽  
Green Fluorescent ◽  
Ventral Diencephalon

scholarly journals TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors

2007 ◽  
Vol 311 (2) ◽  
pp. 396-407 ◽  
Author(s):  
Michelle L. Brinkmeier ◽  
Mary Anne Potok ◽  
Shannon W. Davis ◽  
Sally A. Camper
Keyword(s):  
Ventral Diencephalon

scholarly journals Expression of ventral diencephalon-enriched genes in zebrafish

2010 ◽  
Vol 239 (12) ◽  
pp. 3368-3379 ◽  
Author(s):  
Sen Li ◽  
Min Yin ◽  
Shuxi Liu ◽  
Yi Chen ◽  
Yanqing Yin ◽  
...  
Keyword(s):  
Ventral Diencephalon
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