scholarly journals Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis

Development ◽  
2004 ◽  
Vol 131 (15) ◽  
pp. 3681-3692 ◽  
Author(s):  
W. Herzog
Keyword(s):  
Ventral Diencephalon

FGF3 from the Hypothalamus Regulates the Guidance of Thalamocortical Axons

2020 ◽  
Vol 42 (5-6) ◽  
pp. 208-216
Author(s):  
Kuan Liu ◽  
Zhongsheng Lv ◽  
Hong Huang ◽  
Shuyang Yu ◽  
Li Xiao ◽  
...  
Keyword(s):  
Sensory Information ◽  
Axonal Pathfinding ◽  
Fibroblast Growth ◽  
High Concentration ◽  
Dependent Effect ◽  
Development Stages ◽  
Guidance Cues ◽  
Thalamocortical Axons ◽  
Ventral Diencephalon

Thalamus is an important sensory relay station: afferent sensory information, except olfactory signals, is transmitted by thalamocortical axons (TCAs) to the cerebral cortex. The pathway choice of TCAs depends on diverse diffusible or substrate-bound guidance cues in the environment. Not only classical guidance cues (ephrins, slits, semaphorins, and netrins), morphogens, which exerts patterning effects during early embryonic development, can also help axons navigate to their targets at later development stages. Here, expression analyses reveal that morphogen Fibroblast growth factor (FGF)-3 is expressed in the chick ventral diencephalon, hypothalamus, during the pathfinding of TCAs. Then, using in vitro analyses in chick explants, we identify a concentration-dependent effect of FGF3 on thalamic axons: attractant 100 ng/mL FGF3 transforms to a repellent at high concentration 500 ng/mL. Moreover, inhibition of FGF3 guidance functions indicates that FGF3 signaling is necessary for the correct navigation of thalamic axons. Together, these studies demonstrate a direct effect for the member of FGF7 subfamily, FGF3, in the axonal pathfinding of TCAs.

scholarly journals Wnt genes affect patterning of the ventral diencephalon and pituitary gland growth

2006 ◽  
Vol 295 (1) ◽  
pp. 456
Author(s):  
Mary A. Potok ◽  
Kelly B. Cha ◽  
Andrea Hunt ◽  
Michelle L. Brinkmeier ◽  
Andreas Kispert ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Ventral Diencephalon

Hypocretin/orexin-containing neurons are produced in one sharp peak in the developing ventral diencephalon

2005 ◽  
Vol 22 (2) ◽  
pp. 531-534 ◽  
Author(s):  
C. Amiot ◽  
F. Brischoux ◽  
C. Colard ◽  
A. La Roche ◽  
D. Fellmann ◽  
...  
Keyword(s):  
Sharp Peak ◽  
Ventral Diencephalon

Modeling Parkinson’s Disease in Zebrafish

2020 ◽  
Vol 19 (5) ◽  
pp. 386-399
Author(s):  
Nor H.M. Najib ◽  
Yong H. Nies ◽  
Syarifah A.S. Abd Halim ◽  
Mohamad F. Yahaya ◽  
Srijit Das ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Treatment Strategies ◽  
Mammalian Brain ◽  
Mechanistic Study ◽  
Research Model ◽  
True Nature ◽  
Therapeutic Compounds ◽  
And Control ◽  
Ventral Diencephalon

Parkinson’s Disease (PD) is one of the most common neurodegenerative disorders that affects the motor system, and includes cardinal motor symptoms such as resting tremor, cogwheel rigidity, bradykinesia and postural instability. Its prevalence is increasing worldwide due to the increase in life span. Although, two centuries since the first description of the disease, no proper cure with regard to treatment strategies and control of symptoms could be reached. One of the major challenges faced by the researchers is to have a suitable research model. Rodents are the most common PD models used, but no single model can replicate the true nature of PD. In this review, we aim to discuss another animal model, the zebrafish (Danio rerio), which is gaining popularity. Zebrafish brain has all the major structures found in the mammalian brain, with neurotransmitter systems, and it also possesses a functional blood-brain barrier similar to humans. From the perspective of PD research, the zebrafish possesses the ventral diencephalon, which is thought to be homologous to the mammalian substantia nigra. We summarize the various zebrafish models available to study PD, namely chemical-induced and genetic models. The zebrafish can complement the use of other animal models for the mechanistic study of PD and help in the screening of new potential therapeutic compounds.

scholarly journals Genetic regulation of murine pituitary development

2015 ◽  
Vol 54 (2) ◽  
pp. R55-R73 ◽  
Author(s):  
Karine Rizzoti
Keyword(s):  
Endocrine Cells ◽  
Molecular Mechanisms ◽  
Genetic Regulation ◽  
Three Dimensional ◽  
Significant Progress ◽  
Pituitary Development ◽  
Tumour Formation ◽  
Ventral Diencephalon

Significant progress has been made recently in unravelling the embryonic events leading to pituitary morphogenesis, bothin vivoandin vitro. This includes dissection of the molecular mechanisms controlling patterning of the ventral diencephalon that regulate formation of the pituitary anlagen or Rathke's pouch. There is also a better characterisation of processes that underlie maintenance of pituitary progenitors, specification of endocrine lineages and the three-dimensional organisation of newly differentiated endocrine cells. Furthermore, a population of adult pituitary stem cells (SCs), originating from embryonic progenitors, have been described and shown to have not only regenerative potential, but also the capacity to induce tumour formation. Finally, the successful recapitulationin vitroof embryonic events leading to generation of endocrine cells from embryonic SCs, and their subsequent transplantation, represents exciting advances towards the use of regenerative medicine to treat endocrine deficits. In this review, an up-to-date description of pituitary morphogenesis will be provided and discussed with particular reference to pituitary SC studies.

Transgenic zebrafish expressing green fluorescent protein in dopaminergic neurons of the ventral diencephalon

2011 ◽  
Vol 240 (11) ◽  
pp. 2539-2547 ◽  
Author(s):  
Yanwei Xi ◽  
Man Yu ◽  
Rafael Godoy ◽  
Gary Hatch ◽  
Luc Poitras ◽  
...  
Keyword(s):  
Green Fluorescent Protein ◽  
Dopaminergic Neurons ◽  
Fluorescent Protein ◽  
Transgenic Zebrafish ◽  
Green Fluorescent ◽  
Ventral Diencephalon

scholarly journals TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors

2007 ◽  
Vol 311 (2) ◽  
pp. 396-407 ◽  
Author(s):  
Michelle L. Brinkmeier ◽  
Mary Anne Potok ◽  
Shannon W. Davis ◽  
Sally A. Camper
Keyword(s):  
Ventral Diencephalon

scholarly journals Expression of ventral diencephalon-enriched genes in zebrafish

2010 ◽  
Vol 239 (12) ◽  
pp. 3368-3379 ◽  
Author(s):  
Sen Li ◽  
Min Yin ◽  
Shuxi Liu ◽  
Yi Chen ◽  
Yanqing Yin ◽  
...  
Keyword(s):  
Ventral Diencephalon

scholarly journals Desikan-Killiany-Tourville Atlas Compatible Version of M-CRIB Neonatal Parcellated Whole Brain Atlas: The M-CRIB 2.0

2018 ◽  
Author(s):  
Bonnie Alexander ◽  
Wai Yen Loh ◽  
Lillian G. Matthews ◽  
Andrea L. Murray ◽  
Chris Adamson ◽  
...  
Keyword(s):  
Brain Regions ◽  
Brain Atlas ◽  
Whole Brain ◽  
Brain Structure And Function ◽  
Postmenstrual Age ◽  
Mri Scans ◽  
Subcortical Regions ◽  
Cortical Regions ◽  
And Function ◽  
Ventral Diencephalon

AbstractOur recently published M-CRIB atlas comprises 100 neonatal brain regions including 68 compatible with the widely-used Desikan-Killiany adult cortical atlas. A successor to the Desikan-Killiany atlas is the Desikan-Killiany-Tourville atlas, in which some regions with unclear boundaries were removed, and many existing boundaries were revised to conform to clearer landmarks in sulcal fundi. Our first aim here was to modify cortical M-CRIB regions to comply with the Desikan-Killiany-Tourville protocol, in order to offer: a) compatibility with this adult cortical atlas, b) greater labelling accuracy due to clearer landmarks, and c) optimisation of cortical regions for integration with surface-based infant parcellation pipelines. Secondly, we aimed to update subcortical regions in order to offer greater compatibility with subcortical segmentations produced in FreeSurfer. Data utilized were the T2-weighted MRI scans in our M-CRIB atlas, for ten healthy neonates (postmenstrual age at MRI 40-43 weeks, 4 female), and corresponding parcellated images. Edits were performed on the parcellated images in volume space using ITK-SNAP. Cortical updates included deletion of frontal and temporal poles and ‘Banks STS’, and modification of boundaries of many other regions. Changes to subcortical regions included the addition of ‘ventral diencephalon’, and deletion of ‘subcortical matter’ labels. A detailed updated parcellation protocol was produced. The resulting whole-brain M-CRIB 2.0 atlas comprises 94 regions altogether. This atlas provides comparability with adult Desikan-Killiany-Tourville-labelled cortical data and FreeSurfer-labelled subcortical data, and is more readily adaptable for incorporation into surface-based neonatal parcellation pipelines. As such, it offers the ability to help facilitate a broad range of investigations into brain structure and function both at the neonatal time point and developmentally across the lifespan.

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