scholarly journals The homeobox gene Gsx2 controls the timing of oligodendroglial fate specification in mouse lateral ganglionic eminence progenitors

Development ◽  
2013 ◽  
Vol 140 (11) ◽  
pp. 2289-2298 ◽  
Author(s):  
H. Chapman ◽  
R. R. Waclaw ◽  
Z. Pei ◽  
M. Nakafuku ◽  
K. Campbell
Keyword(s):  
Homeobox Gene ◽  
Ganglionic Eminence ◽  
Fate Specification ◽  
Lateral Ganglionic Eminence

Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation

Development ◽  
1999 ◽  
Vol 126 (6) ◽  
pp. 1317-1326 ◽  
Author(s):  
H. Toresson ◽  
A. Mata de Urquiza ◽  
C. Fagerstrom ◽  
T. Perlmann ◽  
K. Campbell
Keyword(s):  
Retinoic Acid ◽  
Molecular Mechanisms ◽  
Radial Glia ◽  
Homeobox Gene ◽  
Striatal Neuron ◽  
Ganglionic Eminence ◽  
Neuron Differentiation ◽  
Localized Source ◽  
Lateral Ganglionic Eminence ◽  
X Receptors

In order to identify molecular mechanisms involved in striatal development, we employed a subtraction cloning strategy to enrich for genes expressed in the lateral versus the medial ganglionic eminence. Using this approach, the homeobox gene Meis2 was found highly expressed in the lateral ganglionic eminence and developing striatum. Since Meis2 has recently been shown to be upregulated by retinoic acid in P19 EC cells (Oulad-Abdelghani, M., Chazaud, C., Bouillet, P., Sapin, V., Chambon, P. and Dolle, P. (1997) Dev. Dyn. 210, 173–183), we examined a potential role for retinoids in striatal development. Our results demonstrate that the lateral ganglionic eminence, unlike its medial counterpart or the adjacent cerebral cortex, is a localized source of retinoids. Interestingly, glia (likely radial glia) in the lateral ganglionic eminence appear to be a major source of retinoids. Thus, as lateral ganglionic eminence cells migrate along radial glial fibers into the developing striatum, retinoids from these glial cells could exert an effect on striatal neuron differentiation. Indeed, the treatment of lateral ganglionic eminence cells with retinoic acid or agonists for the retinoic acid receptors or retinoid X receptors, specifically enhances their striatal neuron characteristics. These findings, therefore, strongly support the notion that local retinoid signalling within the lateral ganglionic eminence regulates striatal neuron differentiation.

Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog

Development ◽  
1998 ◽  
Vol 125 (24) ◽  
pp. 5079-5089 ◽  
Author(s):  
J.D. Kohtz ◽  
D.P. Baker ◽  
G. Corte ◽  
G. Fishell
Keyword(s):  
Basal Ganglia ◽  
Globus Pallidus ◽  
Sonic Hedgehog ◽  
Adult Brain ◽  
Ganglionic Eminence ◽  
Lateral Ganglionic Eminence ◽  
Expression Characteristic ◽  
Sonic Hedgehog Gene ◽  
Embryonic Structure ◽  
Sequential Induction

The cortex and basal ganglia are the major structures of the adult brain derived from the embryonic telencephalon. Two morphologically distinct regions of the basal ganglia are evident within the mature ventral telencephalon, the globus pallidus medially, and the striatum, which is positioned between the globus pallidus and the cortex. Deletion of the Sonic Hedgehog gene in mice indicates that this secreted signaling molecule is vital for the generation of both these ventral telencephalic regions. Previous experiments showed that Sonic Hedgehog induces differentiation of ventral neurons characteristic of the medial ganglionic eminence, the embryonic structure which gives rise to the globus pallidus. In this paper, we show that later in development, Sonic Hedgehog induces ventral neurons with patterns of gene expression characteristic of the lateral ganglionic eminence. This is the embryonic structure from which the striatum is derived. These results suggest that temporally regulated changes in Sonic Hedgehog responsiveness are integral in the sequential induction of basal telencephalic structures.

Addition of Lateral Ganglionic Eminence to Rat Mesencephalic Grafts Affects Fiber Outgrowth but Does not Enhance Function

1997 ◽  
Vol 6 (3) ◽  
pp. 277-286 ◽  
Author(s):  
Mia Emgard-Mattson ◽  
Jenny Karlsson ◽  
Naoyuki Nakao ◽  
Patrik Brundin
Keyword(s):  
Dopaminergic Neurons ◽  
Recovery Of Function ◽  
Rotational Behavior ◽  
Specific Marker ◽  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence ◽  
Drug Induced ◽  
Lateral Ganglionic Eminence ◽  
Axonal Fiber ◽  
6 Hydroxydopamine

Addition of embryonic striatal tissue, usually as a combination of the lateral and medial ganglionic eminences, to intrastriatal mesencephalic grafts has previously been reported to enhance recovery of drug-induced rotational behavior in the host and to modify axonal fiber outgrowth from the grafted dopaminergic neurons. This study investigated the effects of adding (cografting) either lateral or medial ganglionic eminence tissue to embryonic mesencephalic grafts implanted intrastriatally, in rats with unilateral 6-hydroxydopamine lesions. The cografts did not exhibit increased survival or cell size of dopaminergic neurons when compared to transplants of mesencephalic tissue alone. Neither did recipients of cografts exhibit any enhancement of graft-induced recovery of function, when tested for drug-induced rotational behavior or forelimb function in the staircase test. However, cografts containing lateral ganglionic eminence displayed patches of dense tyrosine hydroxylase-immunoreactive fibers within the graft tissue. These patches largely coincided with patches in adjacent stained sections, which were rich in immunostaining for the striatal-specific marker dopamine- and cyclic AMP-regulated phosphoprotein-32 (DARPP-32). Such patches were not present in rats receiving cografts containing medial ganglionic eminence or mesencephalic tissue alone. Thus, it seems that the grafted dopaminergic neurons preferentially grow into the areas of the transplants containing lateral ganglionic eminence tissue. In summary, the results suggest that embryonic lateral ganglionic eminence exerts trophic effects on the outgrowth of dopaminergic axons, but does not enhance the behavioral effects of grafted dopaminergic neurons.

Long-term survival of fetal porcine lateral ganglionic eminence cells in the hippocampus of rats

1999 ◽  
Vol 56 (6) ◽  
pp. 581-594 ◽  
Author(s):  
Douglas B. Jacoby ◽  
Charles Lindberg ◽  
Miles G. Cunningham ◽  
Judson Ratliff ◽  
Jonathan Dinsmore
Keyword(s):  
Ganglionic Eminence ◽  
Term Survival ◽  
Long Term Survival ◽  
Lateral Ganglionic Eminence

scholarly journals The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification

2018 ◽  
Vol 151 ◽  
pp. 18-29 ◽  
Author(s):  
H.M. Rodgers ◽  
V.J. Huffman ◽  
V.A. Voronina ◽  
M. Lewandoski ◽  
P.H. Mathers
Keyword(s):  
Cell Fate ◽  
Homeobox Gene ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Retinal Progenitor

scholarly journals Cytoarchitecture of the lateral ganglionic eminence and rostral extension of the lateral ventricle in the human fetal brain

2011 ◽  
Vol 519 (6) ◽  
pp. 1165-1180 ◽  
Author(s):  
Hugo Guerrero-Cázares ◽  
Oscar Gonzalez-Perez ◽  
Mario Soriano-Navarro ◽  
Grettel Zamora-Berridi ◽  
José Manuel García-Verdugo ◽  
...  
Keyword(s):  
Lateral Ventricle ◽  
Fetal Brain ◽  
Ganglionic Eminence ◽  
Human Fetal Brain ◽  
Lateral Ganglionic Eminence

scholarly journals The Gli3 Hypomorphic Mutation Pdn Causes Selective Impairment in the Growth, Patterning, and Axon Guidance Capability of the Lateral Ganglionic Eminence

2010 ◽  
Vol 30 (41) ◽  
pp. 13883-13894 ◽  
Author(s):  
D. Magnani ◽  
K. Hasenpusch-Theil ◽  
E. C. Jacobs ◽  
A. T. Campagnoni ◽  
D. J. Price ◽  
...  
Keyword(s):  
Axon Guidance ◽  
Ganglionic Eminence ◽  
Hypomorphic Mutation ◽  
Lateral Ganglionic Eminence ◽  
Selective Impairment
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