scholarly journals Tissue-specific function of Patj in regulating the Crumbs complex and epithelial polarity

Development ◽  
2012 ◽  
Vol 139 (24) ◽  
pp. 4549-4554 ◽  
Author(s):  
C. Penalva ◽  
V. Mirouse
Keyword(s):  
Epithelial Polarity ◽  
Specific Function ◽  
Tissue Specific ◽  
Crumbs Complex

MACF1, versatility in tissue-specific function and in human disease

2017 ◽  
Vol 69 ◽  
pp. 3-8 ◽  
Author(s):  
Lifang Hu ◽  
Yunyun Xiao ◽  
Zhipeng Xiong ◽  
Fan Zhao ◽  
Chong Yin ◽  
...  
Keyword(s):  
Human Disease ◽  
Specific Function ◽  
Tissue Specific

scholarly journals The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis

Development ◽  
2011 ◽  
Vol 138 (12) ◽  
pp. 2631-2631
Author(s):  
S. Senger ◽  
J. Csokmay ◽  
T. Akbar ◽  
T. I. Jones ◽  
P. Sengupta ◽  
...  
Keyword(s):  
Specific Function ◽  
Tissue Specific ◽  
Drosophila Oogenesis

scholarly journals Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 ◽  
Vol 118 (5) ◽  
pp. 1271-1282 ◽  
Author(s):  
R S Talhouk ◽  
M J Bissell ◽  
Z Werb
Keyword(s):  
Extracellular Matrix ◽  
Plasminogen Activator ◽  
Active Form ◽  
Mammary Epithelial ◽  
Lactation Period ◽  
Specific Function ◽  
Plasminogen Activator Inhibitor 1 ◽  
Tissue Specific ◽  
Ecm Remodeling ◽  
Beta Casein

Extracellular matrix (ECM) plays an important role in the maintenance of mammary epithelial differentiation in culture. We asked whether changes in mouse mammary specific function in vivo correlate with changes in the ECM. We showed, using expression of beta-casein as a marker, that the temporal expression of ECM-degrading proteinases and their inhibitors during lactation and involution are inversely related to functional differentiation. After a lactation period of 9 d, mammary epithelial cells maintained beta-casein expression up to 5 d of involution. Two metalloproteinases, 72-kD gelatinase (and its 62-kD active form), and stromelysin, and a serine proteinase tissue plasminogen activator were detected by day four of involution, and maintained expression until at least day 10. The expression of their inhibitors, the tissue inhibitor of metalloproteinases (TIMP) and plasminogen activator inhibitor-1, preceded the onset of ECM-degrading proteinase expression and was detected by day two of involution, and showed a sharp peak of expression centered on days 4-6 of involution. When involution was accelerated by decreasing lactation to 2 d, there was an accelerated loss of beta-casein expression evident by day four and a shift in expression of ECM-remodeling proteinases and inhibitors to a focus at 2-4 d of involution. To further extend the correlation between mammary-specific function and ECM remodeling we initiated involution by sealing just one gland in an otherwise hormonally sufficient lactating animal. Alveoli in the sealed gland contained casein for at least 7 d after sealing, and closely resembled those in a lactating gland. The relative expression of TIMP in the sealed gland increased, whereas the expression of stromelysin was much lower than that of a hormone-depleted involuting gland, indicating that the higher the ratio of TIMP to ECM-degrading proteinases the slower the process of involution. To test directly the functional role of ECM-degrading proteinases in the loss of tissue-specific function we artificially perturbed the ECM-degrading proteinase-inhibitor ratio in a normally involuting gland by maintaining high concentrations of TIMP protein with the use of surgically implanted slow-release pellets. In a concentration-dependent fashion, involuting mammary glands that received TIMP implants maintained high levels of casein and delayed alveolar regression. These data suggest that the balance of ECM-degrading proteinases and their inhibitors regulates the organization of the basement membrane and the tissue-specific function of the mammary gland.(ABSTRACT TRUNCATED AT 400 WORDS)

scholarly journals Differential Tissue-Specific Function of Adora2b in Cardioprotection

2015 ◽  
Vol 195 (4) ◽  
pp. 1732-1743 ◽  
Author(s):  
Seong-wook Seo ◽  
Michael Koeppen ◽  
Stephanie Bonney ◽  
Merit Gobel ◽  
Molly Thayer ◽  
...  
Keyword(s):  
Specific Function ◽  
Tissue Specific ◽  
Differential Tissue

scholarly journals Interplay of MPP5a with Rab11 synergistically builds epithelial apical polarity and zonula adherens

Development ◽  
2020 ◽  
Vol 147 (22) ◽  
pp. dev184457
Author(s):  
Yumei Hao ◽  
Yao Zhou ◽  
Yinhui Yu ◽  
Mingjie Zheng ◽  
Kechao Weng ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Driving Force ◽  
Adherens Junction ◽  
Small Gtpase ◽  
Epithelial Polarity ◽  
Apical Domain ◽  
Neuroepithelial Cells ◽  
Apical Polarity ◽  
Crumbs Complex ◽  
Remodeling Pattern

ABSTRACTAdherens junction remodeling regulated by apical polarity proteins constitutes a major driving force for tissue morphogenesis, although the precise mechanism remains inconclusive. Here, we report that, in zebrafish, the Crumbs complex component MPP5a interacts with small GTPase Rab11 in Golgi to transport cadherin and Crumbs components synergistically to the apical domain, thus establishing apical epithelial polarity and adherens junctions. In contrast, Par complex recruited by MPP5a is incapable of interacting with Rab11 but might assemble cytoskeleton to facilitate cadherin exocytosis. In accordance, dysfunction of MPP5a induces an invasive migration of epithelial cells. This adherens junction remodeling pattern is frequently observed in zebrafish lens epithelial cells and neuroepithelial cells. The data identify an unrecognized MPP5a-Rab11 complex and describe its essential role in guiding apical polarization and zonula adherens formation in epithelial cells.

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