scholarly journals Neurogenin 2 regulates progenitor cell-cycle progression and Purkinje cell dendritogenesis in cerebellar development

Development ◽  
2012 ◽  
Vol 139 (13) ◽  
pp. 2308-2320 ◽  
Author(s):  
M. Florio ◽  
K. Leto ◽  
L. Muzio ◽  
A. Tinterri ◽  
A. Badaloni ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Purkinje Cell ◽  
Progenitor Cell ◽  
Cell Cycle Progression ◽  
Cerebellar Development ◽  
Cycle Progression

scholarly journals Dual control exerted by dopamine in blood-progenitor cell cycle regulation in Drosophila

2021 ◽  
Author(s):  
Tina Mukherjee ◽  
Ankita Kapoor ◽  
A Padmavathi
Keyword(s):  
Cell Cycle ◽  
Progenitor Cells ◽  
Progenitor Cell ◽  
Cell Cycle Progression ◽  
Lymph Gland ◽  
Cycle Progression ◽  
Myeloid Progenitor ◽  
G2 Phase ◽  
And Function ◽  
Cycle Regulation

In Drosophila, definitive hematopoiesis occurs in a specialized organ termed "lymph gland", where multi-potent stem-like blood progenitor cells reside and their homeostasis is central to growth of this organ. Recent findings have implicated a reliance on neurotransmitters in progenitor development and function however, our understanding of these molecules is still limited. Here, we extend our analysis and show that blood-progenitors are self-sufficient in synthesizing dopamine, a well-established neurotransmitter and have modules for its sensing through receptor and uptake via, transporter. Modulating their expression in progenitor cells affects lymph gland growth. Progenitor cell cycle analysis revealed an unexpected requirement for intracellular dopamine in progression of early progenitors from S to G2 phase of the cell cycle, while activation of dopamine-receptor later in development regulated the progression from G2 to entry into mitosis. The dual capacity in which dopamine operates, both intra-cellularly and extra-cellularly, controls lymph gland growth. These data highlight a novel and non-canonical use of dopamine as a proliferative cue by the myeloid-progenitor system and reveals a functional requirement for intracellular dopamine in cell-cycle progression.

scholarly journals Sox17 Promotes Cell Cycle Progression and Inhibits TGF-β/Smad3 Signaling to Initiate Progenitor Cell Behavior in the Respiratory Epithelium

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5711 ◽  
Author(s):  
Alexander W. Lange ◽  
Angela R. Keiser ◽  
James M. Wells ◽  
Aaron M. Zorn ◽  
Jeffrey A. Whitsett
Keyword(s):  
Cell Cycle ◽  
Progenitor Cell ◽  
Cell Cycle Progression ◽  
Respiratory Epithelium ◽  
Cell Behavior ◽  
Cycle Progression

scholarly journals Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation

2009 ◽  
Vol 4 (1) ◽  
pp. 25 ◽  
Author(s):  
Javorina Milosevic ◽  
Sigrid C Schwarz ◽  
Vera Ogunlade ◽  
Anne K Meyer ◽  
Alexander Storch ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Progenitor Cell ◽  
Cell Cycle Progression ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Cycle Progression ◽  
Human Neural Progenitor Cell

scholarly journals CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum

2021 ◽  
Author(s):  
Chia-Hsiang Chang ◽  
Ting-Yu Chen ◽  
I-Ling Lu ◽  
Rong-Bin Li ◽  
Jhih-Jie Tsai ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Neuronal Differentiation ◽  
Cell Cycle Progression ◽  
Joubert Syndrome ◽  
Cerebellar Development ◽  
Cycle Progression ◽  
Interacting Protein ◽  
Germinal Zone ◽  
Developing Cerebellum

Joubert syndrome (JS) is a recessive ciliopathy in which all affected individuals have congenital cerebellar vermis hypoplasia. Here, we report that CEP120, a JS-associated protein involved in centriole biogenesis and cilia assembly, regulates timely neuronal differentiation and the departure of granule neuron progenitors (GNPs) from their germinal zone during cerebellar development. Our results show that depletion of Cep120 perturbs GNP cell cycle progression, resulting in a delay of cell cycle exit in vivo. To dissect the potential mechanism, we investigated the association between CEP120 interactome and the JS database and identified KIAA0753 (a JS-associated protein) as a CEP120-interacting protein. Surprisingly, we found that CEP120 recruits KIAA0753 to centrioles, and that loss of this interaction induces accumulation of GNPs in the germinal zone and impairs neuronal differentiation. Importantly, the replenishment of wild-type CEP120 rescues the above defects, whereas expression of JS-associated CEP120 mutants, which hinder KIAA0753 recruitment, does not. Together, our data reveal a close interplay between CEP120 and KIAA0753 for the germinal zone exit and timely neuronal differentiation of GNPs during cerebellar development, and mutations in CEP120 and KIAA0753 may participate in the heterotopia and cerebellar hypoplasia observed in JS patients.

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