scholarly journals Tissue nonspecific alkaline phosphatase promotes calvarial progenitor cell cycle progression and cytokinesis via Erk1,2

Bone ◽  
2019 ◽  
Vol 120 ◽  
pp. 125-136 ◽  
Author(s):  
Hwa Kyung Nam ◽  
Iva Vesela ◽  
Erica Siismets ◽  
Nan E. Hatch
Keyword(s):  
Cell Cycle ◽  
Alkaline Phosphatase ◽  
Progenitor Cell ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Tissue Nonspecific Alkaline Phosphatase

scholarly journals Dual control exerted by dopamine in blood-progenitor cell cycle regulation in Drosophila

2021 ◽  
Author(s):  
Tina Mukherjee ◽  
Ankita Kapoor ◽  
A Padmavathi
Keyword(s):  
Cell Cycle ◽  
Progenitor Cells ◽  
Progenitor Cell ◽  
Cell Cycle Progression ◽  
Lymph Gland ◽  
Cycle Progression ◽  
Myeloid Progenitor ◽  
G2 Phase ◽  
And Function ◽  
Cycle Regulation

In Drosophila, definitive hematopoiesis occurs in a specialized organ termed "lymph gland", where multi-potent stem-like blood progenitor cells reside and their homeostasis is central to growth of this organ. Recent findings have implicated a reliance on neurotransmitters in progenitor development and function however, our understanding of these molecules is still limited. Here, we extend our analysis and show that blood-progenitors are self-sufficient in synthesizing dopamine, a well-established neurotransmitter and have modules for its sensing through receptor and uptake via, transporter. Modulating their expression in progenitor cells affects lymph gland growth. Progenitor cell cycle analysis revealed an unexpected requirement for intracellular dopamine in progression of early progenitors from S to G2 phase of the cell cycle, while activation of dopamine-receptor later in development regulated the progression from G2 to entry into mitosis. The dual capacity in which dopamine operates, both intra-cellularly and extra-cellularly, controls lymph gland growth. These data highlight a novel and non-canonical use of dopamine as a proliferative cue by the myeloid-progenitor system and reveals a functional requirement for intracellular dopamine in cell-cycle progression.

Expression and visualization during cell cycle progression of alkaline phosphatase in B lymphocytes from C3H/HeJ mice

1994 ◽  
Vol 55 (5) ◽  
pp. 626-632 ◽  
Author(s):  
Vongthip Souvannavong ◽  
Spencer Brown ◽  
M'hammed Sarih ◽  
Arlette Adam
Keyword(s):  
Cell Cycle ◽  
Alkaline Phosphatase ◽  
B Lymphocytes ◽  
Cell Cycle Progression ◽  
Cycle Progression

scholarly journals Sox17 Promotes Cell Cycle Progression and Inhibits TGF-β/Smad3 Signaling to Initiate Progenitor Cell Behavior in the Respiratory Epithelium

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5711 ◽  
Author(s):  
Alexander W. Lange ◽  
Angela R. Keiser ◽  
James M. Wells ◽  
Aaron M. Zorn ◽  
Jeffrey A. Whitsett
Keyword(s):  
Cell Cycle ◽  
Progenitor Cell ◽  
Cell Cycle Progression ◽  
Respiratory Epithelium ◽  
Cell Behavior ◽  
Cycle Progression

scholarly journals Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation

2009 ◽  
Vol 4 (1) ◽  
pp. 25 ◽  
Author(s):  
Javorina Milosevic ◽  
Sigrid C Schwarz ◽  
Vera Ogunlade ◽  
Anne K Meyer ◽  
Alexander Storch ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Progenitor Cell ◽  
Cell Cycle Progression ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Cycle Progression ◽  
Human Neural Progenitor Cell

scholarly journals Neurogenin 2 regulates progenitor cell-cycle progression and Purkinje cell dendritogenesis in cerebellar development

Development ◽  
2012 ◽  
Vol 139 (13) ◽  
pp. 2308-2320 ◽  
Author(s):  
M. Florio ◽  
K. Leto ◽  
L. Muzio ◽  
A. Tinterri ◽  
A. Badaloni ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Purkinje Cell ◽  
Progenitor Cell ◽  
Cell Cycle Progression ◽  
Cerebellar Development ◽  
Cycle Progression
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