scholarly journals DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages

Development ◽  
2006 ◽  
Vol 133 (17) ◽  
pp. 3411-3418 ◽  
Author(s):  
D. M. Maatouk
Keyword(s):  
Dna Methylation ◽  
Germ Cell ◽  
Somatic Cell ◽  
Primordial Germ Cell ◽  
Cell Lineages ◽  
Primary Mechanism

Sall4 Is Essential for Mouse Primordial Germ Cell Specification by Suppressing Somatic Cell Program Genes

Stem Cells ◽  
2014 ◽  
Vol 33 (1) ◽  
pp. 289-300 ◽  
Author(s):  
Yasuka L. Yamaguchi ◽  
Satomi S. Tanaka ◽  
Maho Kumagai ◽  
Yuka Fujimoto ◽  
Takeshi Terabayashi ◽  
...  
Keyword(s):  
Germ Cell ◽  
Somatic Cell ◽  
Primordial Germ Cell ◽  
Cell Specification ◽  
Germ Cell Specification ◽  
Mouse Primordial Germ Cell

scholarly journals Effects of Dppa3 on DNA Methylation Dynamics During Primordial Germ Cell Development in Mice1

2013 ◽  
Vol 88 (5) ◽  
Author(s):  
Hiroyuki Nakashima ◽  
Tohru Kimura ◽  
Yoshiaki Kaga ◽  
Tsunetoshi Nakatani ◽  
Yoshiyuki Seki ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Cell Development ◽  
Germ Cell Development

The dynamic changes of DNA methylation in primordial germ cell differentiation

Gene ◽  
2016 ◽  
Vol 591 (2) ◽  
pp. 305-312 ◽  
Author(s):  
Lian Duan ◽  
Yongmei Liu ◽  
Jie Wang ◽  
Jiangquan Liao ◽  
Junyuan Hu
Keyword(s):  
Dna Methylation ◽  
Cell Differentiation ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Dynamic Changes ◽  
Germ Cell Differentiation

scholarly journals Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification

2016 ◽  
Vol 39 (1) ◽  
pp. 104-115 ◽  
Author(s):  
Ferdinand von Meyenn ◽  
Rebecca V. Berrens ◽  
Simon Andrews ◽  
Fátima Santos ◽  
Amanda J. Collier ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Cell Specification ◽  
Germ Cell Specification ◽  
Human And Mouse

scholarly journals Induction of meiosis by embryonic gonadal somatic cells differentiated from pluripotent stem cells

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Haiying Wang ◽  
Linlin Liu ◽  
Chang Liu ◽  
Lingling Wang ◽  
Jiyu Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Germ Cell ◽  
Small Molecules ◽  
Somatic Cell ◽  
Pluripotent Stem Cells ◽  
Primordial Germ Cell ◽  
Somatic Cells ◽  
Embryonic Stem

Abstract Background Depletion of oocytes leads to ovarian aging-associated infertility, endocrine disruption and related diseases. Excitingly, unlimited oocytes can be generated by differentiation of primordial germ cell like cells (PGCLCs) from pluripotent stem cells. Nevertheless, development of oocytes and follicles from PGCLCs relies on developmentally matched gonadal somatic cells, only available from E12.5 embryos in mice. It is therefore imperative to achieve an in vitro source of E12.5 gonadal somatic cells. Methods We explored to identify small molecules, which can induce female embryonic stem cells (ESCs) into gonadal somatic cell like cells. Results Using RNA-sequencing, we identified signaling pathways highly upregulated in E12.5_gonadal somatic cells (E12.5_GSCs). Through searching for the activators of these pathways, we identified small-molecule compounds Vitamin C (Vc) and AM580 in combination (V580) for inducing differentiation of female embryonic stem cells (ESCs) into E12.5_GSC-like cells (E12.5_GSCLCs). After V580 treatment for 6 days and sorted by a surface marker CD63, the cell population yielded a transcriptome profile similar to that of E12.5_GSCs, which promoted meiosis progression and folliculogenesis of primordial germ cells. This approach will contribute to the study of germ cell and follicle development and oocyte production and have implications in potentially treating female infertility. Conclusion ESCs can be induced into embryonic gonadal somatic cell like cells by small molecules.

scholarly journals 05-P018 Changes in Genomewide DNA Methylation during Primordial Germ Cell Development in the Porcine Embryo

2009 ◽  
Vol 126 ◽  
pp. S118
Author(s):  
Sara Maj Wätjen Hyldig ◽  
Olga Østrup ◽  
Morten Vejlsted ◽  
Preben Dybdahl Thomsen
Keyword(s):  
Dna Methylation ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Cell Development ◽  
Germ Cell Development ◽  
Porcine Embryo
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