scholarly journals 05-P018 Changes in Genomewide DNA Methylation during Primordial Germ Cell Development in the Porcine Embryo

2009 ◽  
Vol 126 ◽  
pp. S118
Author(s):  
Sara Maj Wätjen Hyldig ◽  
Olga Østrup ◽  
Morten Vejlsted ◽  
Preben Dybdahl Thomsen
Keyword(s):  
Dna Methylation ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Cell Development ◽  
Germ Cell Development ◽  
Porcine Embryo

scholarly journals Effects of Dppa3 on DNA Methylation Dynamics During Primordial Germ Cell Development in Mice1

2013 ◽  
Vol 88 (5) ◽  
Author(s):  
Hiroyuki Nakashima ◽  
Tohru Kimura ◽  
Yoshiaki Kaga ◽  
Tsunetoshi Nakatani ◽  
Yoshiyuki Seki ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Cell Development ◽  
Germ Cell Development

scholarly journals Persistent Requirement and Alteration of the Key Targets of PRDM1 During Primordial Germ Cell Development in Mice1

2016 ◽  
Vol 94 (1) ◽  
Author(s):  
Chika Yamashiro ◽  
Takayuki Hirota ◽  
Kazuki Kurimoto ◽  
Tomonori Nakamura ◽  
Yukihiro Yabuta ◽  
...  
Keyword(s):  
Germ Cell ◽  
Primordial Germ Cell ◽  
Cell Development ◽  
Germ Cell Development

scholarly journals MicroRNA Biogenesis Is Required for Mouse Primordial Germ Cell Development and Spermatogenesis

PLoS ONE ◽  
2008 ◽  
Vol 3 (3) ◽  
pp. e1738 ◽  
Author(s):  
Katsuhiko Hayashi ◽  
Susana M. Chuva de Sousa Lopes ◽  
Masahiro Kaneda ◽  
Fuchou Tang ◽  
Petra Hajkova ◽  
...  
Keyword(s):  
Germ Cell ◽  
Primordial Germ Cell ◽  
Cell Development ◽  
Microrna Biogenesis ◽  
Germ Cell Development ◽  
Mouse Primordial Germ Cell

scholarly journals PI3K/PTEN/AKT Signaling Pathways in Germ Cell Development and Their Involvement in Germ Cell Tumors and Ovarian Dysfunctions

2021 ◽  
Vol 22 (18) ◽  
pp. 9838
Author(s):  
Massimo De Felici ◽  
Francesca Gioia Klinger
Keyword(s):  
Germ Cell ◽  
Signaling Pathways ◽  
Ovarian Function ◽  
Primordial Germ Cells ◽  
Primordial Germ Cell ◽  
Germ Cell Tumors ◽  
Primordial Follicle ◽  
Akt Signaling ◽  
Cell Development ◽  
Germ Cell Development

Several studies indicate that the PI3K/PTEN/AKT signaling pathways are critical regulators of ovarian function including the formation of the germ cell precursors, termed primordial germ cells, and the follicular pool maintenance. This article reviews the current state of knowledge of the functional role of the PI3K/PTEN/AKT pathways during primordial germ cell development and the dynamics of the ovarian primordial follicle reserve and how dysregulation of these signaling pathways may contribute to the development of some types of germ cell tumors and ovarian dysfunctions.

nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans

Development ◽  
1999 ◽  
Vol 126 (21) ◽  
pp. 4861-4871 ◽  
Author(s):  
K. Subramaniam ◽  
G. Seydoux
Keyword(s):  
Caenorhabditis Elegans ◽  
Germ Cell ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Primordial Germ Cell ◽  
Gene Families ◽  
Cell Development ◽  
Embryonic Patterning ◽  
Germ Cell Development ◽  
C Elegans

In Drosophila, the posterior determinant nanos is required for embryonic patterning and for primordial germ cell (PGC) development. We have identified three genes in Caenorhabditis elegans that contain a putative zinc-binding domain similar to the one found in nanos, and show that two of these genes function during PGC development. Like Drosophila nanos, C. elegans nos-1 and nos-2 are not generally required for PGC fate specification, but instead regulate specific aspects of PGC development. nos-2 is expressed in PGCs around the time of gastrulation from a maternal RNA associated with P granules, and is required for the efficient incorporation of PGCs into the somatic gonad. nos-1 is expressed in PGCs after gastrulation, and is required redundantly with nos-2 to prevent PGCs from dividing in starved animals and to maintain germ cell viability during larval development. In the absence of nos-1 and nos-2, germ cells cease proliferation at the end of the second larval stage, and die in a manner that is partially dependent on the apoptosis gene ced-4. Our results also indicate that putative RNA-binding proteins related to Drosophila Pumilio are required for the same PGC processes as nos-1 and nos-2. These studies demonstrate that evolutionarily distant organisms utilize conserved factors to regulate early germ cell development and survival, and that these factors include members of the nanos and pumilio gene families.

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