scholarly journals Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst

Development ◽  
2005 ◽  
Vol 132 (9) ◽  
pp. 2093-2102 ◽  
Author(s):  
D. Strumpf
Keyword(s):  
Cell Fate ◽  
Cell Fate Specification ◽  
Mouse Blastocyst ◽  
Fate Specification

scholarly journals Lumen expansion facilitates epiblast-primitive endoderm fate specification in the mouse blastocyst formation

2019 ◽  
Author(s):  
Allyson Quinn Ryan ◽  
Chii Jou Chan ◽  
François Graner ◽  
Takashi Hiiragi
Keyword(s):  
Cell Fate ◽  
Critical Role ◽  
Spatial Segregation ◽  
General Mechanism ◽  
Cell Fate Specification ◽  
Blastocyst Formation ◽  
Primitive Endoderm ◽  
Mouse Blastocyst ◽  
Fate Specification ◽  
Cell Fate Control

SummaryMouse blastocyst formation involves lumen formation and cell fate specification. While many studies have investigated how the blastocyst cell lineages are specified through genetics and signaling, studies into the potential role of the fluid lumen have yet to be conducted. We discover that blastocyst fluid emerges by secretion of cytoplasmic vesicles to intercellular space in addition to trans-epithelial flow. We observe that the beginning of epiblast and primitive endoderm spatial segregation directly follows lumen coalescence. Notably, we show that perturbing lumen expansion by pharmacological and biophysical means impair the specification and spatial segregation of primitive endoderm cells within the blastocyst. Combined, our results suggest that blastocyst lumen expansion plays a critical role in guiding cell fate specification and positioning. As epithelial tissues typically form lumina, lumen expansion may provide a general mechanism of cell fate control in many tissues.

Sox proteins: regulators of cell fate specification and differentiation

Development ◽  
2013 ◽  
Vol 140 (20) ◽  
pp. 4129-4144 ◽  
Author(s):  
Y. Kamachi ◽  
H. Kondoh
Keyword(s):  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Sox Proteins

scholarly journals Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification

2003 ◽  
Vol 259 (1) ◽  
pp. 150-161 ◽  
Author(s):  
Jun Motoyama ◽  
Ljiljana Milenkovic ◽  
Mizuho Iwama ◽  
Yayoi Shikata ◽  
Matthew P. Scott ◽  
...  
Keyword(s):  
Cell Fate ◽  
Neural Cell ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Neural Cell Fate
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