scholarly journals Notch signaling controls germline stem cell niche formation in the Drosophila ovary

Development ◽  
2007 ◽  
Vol 134 (6) ◽  
pp. 1071-1080 ◽  
Author(s):  
X. Song ◽  
G. B. Call ◽  
D. Kirilly ◽  
T. Xie
Keyword(s):  
Stem Cell ◽  
Notch Signaling ◽  
Stem Cell Niche ◽  
Germline Stem Cell ◽  
Niche Formation ◽  
Cell Niche ◽  
Germline Stem Cell Niche ◽  
Drosophila Ovary

scholarly journals Distant activation of Notch signaling induces stem cell niche assembly

PLoS Genetics ◽  
2021 ◽  
Vol 17 (3) ◽  
pp. e1009489
Author(s):  
Andriy S. Yatsenko ◽  
Halyna R. Shcherbata
Keyword(s):  
Stem Cell ◽  
Notch Signaling ◽  
Cell Fate ◽  
Stem Cell Niche ◽  
Germline Stem Cell ◽  
Cellular Interactions ◽  
Niche Assembly ◽  
Cell Niche ◽  
Germline Stem Cell Niche ◽  
Signaling Activation

Here we show that multiple modes of Notch signaling activation specify the complexity of spatial cellular interactions necessary for stem cell niche assembly. In particular, we studied the formation of the germline stem cell niche in Drosophila ovaries, which is a two-step process whereby terminal filaments are formed first. Then, terminal filaments signal to the adjacent cap cell precursors, resulting in Notch signaling activation, which is necessary for the lifelong acquisition of stem cell niche cell fate. The genetic data suggest that in order to initiate the process of stem cell niche assembly, Notch signaling is activated among non-equipotent cells via distant induction, where germline Delta is delivered to somatic cells located several diameters away via cellular projections generated by primordial germ cells. At the same time, to ensure the robustness of niche formation, terminal filament cell fate can also be induced by somatic Delta via cis- or trans-inhibition. This exemplifies a double security mechanism that guarantees that the germline stem cell niche is formed, since it is indispensable for the adjacent germline precursor cells to acquire and maintain stemness necessary for successful reproduction. These findings contribute to our understanding of the formation of stem cell niches in their natural environment, which is important for stem cell biology and regenerative medicine.

scholarly journals Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila

2015 ◽  
Vol 400 (1) ◽  
pp. 33-42 ◽  
Author(s):  
Elizabeth T. Ables ◽  
Kelly E. Bois ◽  
Caroline A. Garcia ◽  
Daniela Drummond-Barbosa
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Germline Stem Cell ◽  
Response Gene ◽  
Niche Formation ◽  
Cell Niche ◽  
Germline Stem Cell Niche

scholarly journals The Wnt pathway limits BMP signaling outside of the germline stem cell niche in Drosophila ovaries

2016 ◽  
Vol 417 (1) ◽  
pp. 50-62 ◽  
Author(s):  
Violaine I. Mottier-Pavie ◽  
Victor Palacios ◽  
Susan Eliazer ◽  
Shane Scoggin ◽  
Michael Buszczak
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Wnt Pathway ◽  
Bmp Signaling ◽  
Germline Stem Cell ◽  
Cell Niche ◽  
Germline Stem Cell Niche

scholarly journals Local BMP receptor activation at adherens junctions in the Drosophila germline stem cell niche

2011 ◽  
Vol 2 (1) ◽  
Author(s):  
Marcus Michel ◽  
Isabel Raabe ◽  
Adam P. Kupinski ◽  
Raquel Pérez-Palencia ◽  
Christian Bökel
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Adherens Junctions ◽  
Receptor Activation ◽  
Germline Stem Cell ◽  
Bmp Receptor ◽  
Cell Niche ◽  
Germline Stem Cell Niche
Sign in / Sign up

Export Citation Format

Share Document