scholarly journals The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm

Development ◽  
2003 ◽  
Vol 130 (4) ◽  
pp. 805-816 ◽  
Author(s):  
L. Collavin
Keyword(s):  
Negative Feedback ◽  
Related Protein ◽  
Feedback Regulator

Thrombin induces IL-10 production in microglia as a negative feedback regulator of TNF-α release

Neuroreport ◽  
2002 ◽  
Vol 13 (6) ◽  
pp. 849-852 ◽  
Author(s):  
Kyung You Kim ◽  
Min Young Kim ◽  
Hee Seung Choi ◽  
Byung Kwan Jin ◽  
Seung Up Kim ◽  
...  
Keyword(s):  
Negative Feedback ◽  
Tnf Α ◽  
Feedback Regulator

scholarly journals Odd skipped related 1is a negative feedback regulator of nodal-induced endoderm development

2014 ◽  
Vol 243 (12) ◽  
pp. 1571-1580 ◽  
Author(s):  
Alexandra V. Terashima ◽  
Sudha P. Mudumana ◽  
Iain A. Drummond
Keyword(s):  
Negative Feedback ◽  
Endoderm Development ◽  
Feedback Regulator

FLU, a negative feedback regulator of tetrapyrrole biosynthesis, is physically linked to the final steps of the Mg++ -branch of this pathway

FEBS Letters ◽  
2011 ◽  
Vol 586 (3) ◽  
pp. 211-216 ◽  
Author(s):  
Dominika Kauss ◽  
Sylvain Bischof ◽  
Sandro Steiner ◽  
Klaus Apel ◽  
Rasa Meskauskiene
Keyword(s):  
Negative Feedback ◽  
Tetrapyrrole Biosynthesis ◽  
Feedback Regulator

scholarly journals Specificity and modulation of the action of lactoferrin, a negative feedback regulator of myelopoiesis

Blood ◽  
1980 ◽  
Vol 55 (2) ◽  
pp. 324-333 ◽  
Author(s):  
HE Broxmeyer ◽  
M DeSousa ◽  
A Smithyman ◽  
P Ralph ◽  
J Hamilton ◽  
...  
Keyword(s):  
Negative Feedback ◽  
Feedback Regulator

scholarly journals Vasohibin-1, a Negative Feedback Regulator of Angiogenesis, Ameliorates Renal Alterations in a Mouse Model of Diabetic Nephropathy

Diabetes ◽  
2009 ◽  
Vol 58 (10) ◽  
pp. 2365-2375 ◽  
Author(s):  
T. Nasu ◽  
Y. Maeshima ◽  
M. Kinomura ◽  
K. Hirokoshi-Kawahara ◽  
K. Tanabe ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mouse Model ◽  
Negative Feedback ◽  
Feedback Regulator

scholarly journals Transforming growth factor-β-stimulated clone-22 is a negative-feedback regulator of Ras / Raf signaling: Implications for tumorigenesis

2011 ◽  
Vol 103 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Masaki Nakamura ◽  
Jiro Kitaura ◽  
Yutaka Enomoto ◽  
Yang Lu ◽  
Koutarou Nishimura ◽  
...  
Keyword(s):  
Growth Factor ◽  
Negative Feedback ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Feedback Regulator

scholarly journals Anatomy of a negative feedback loop: the case of I κ B α

2015 ◽  
Vol 12 (110) ◽  
pp. 20150262 ◽  
Author(s):  
Riku Fagerlund ◽  
Marcelo Behar ◽  
Karen T. Fortmann ◽  
Y. Eason Lin ◽  
Jesse D. Vargas ◽  
...  
Keyword(s):  
Negative Feedback ◽  
Nuclear Import ◽  
Nuclear Export ◽  
Feedback Loop ◽  
Signalling Pathway ◽  
Imaging Studies ◽  
Negative Feedback Loops ◽  
Emergent Systems ◽  
Negative Feedback Control ◽  
Feedback Regulator

The magnitude, duration and oscillation of cellular signalling pathway responses are often limited by negative feedback loops, defined as an ‘activator-induced inhibitor’ regulatory motif. Within the NF κ B signalling pathway, a key negative feedback regulator is I κ B α . We show here that, contrary to current understanding, NF κ B-inducible expression is not sufficient for providing effective negative feedback. We then employ computational simulations of NF κ B signalling to identify I κ B α molecular properties that are critical for proper negative feedback control and test the resulting predictions in biochemical and single-cell live-imaging studies. We identified nuclear import and nuclear export of I κ B α and the I κ B α –NF κ B complex, as well as the free I κ B α half-life, as key determinants of post-induction repression of NF κ B and the potential for subsequent reactivation. Our work emphasizes that negative feedback is an emergent systems property determined by multiple molecular and biophysical properties in addition to the required ‘activator-induced inhibitor’ relationship.

Sign in / Sign up

Export Citation Format

Share Document