scholarly journals The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells

Development ◽  
2007 ◽  
Vol 134 (13) ◽  
pp. 2491-2500 ◽  
Author(s):  
S. B. Nelson ◽  
A. E. Schaffer ◽  
M. Sander
Keyword(s):  
Transcription Factors ◽  
Beta Cell ◽  
Progenitor Cells ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Pancreatic Progenitor ◽  
Fate Specification ◽  
Pancreatic Progenitor Cells

Ectopic Expression of the Immune Adaptor Protein CD3zeta in Neural Stem/Progenitor Cells Disrupts Cell-Fate Specification

2011 ◽  
Vol 46 (2) ◽  
pp. 431-441 ◽  
Author(s):  
Julie Angibaud ◽  
Stéphane J. Baudouin ◽  
Antoine Louveau ◽  
Véronique Nerrière-Daguin ◽  
Virginie Bonnamain ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Cell Fate ◽  
Ectopic Expression ◽  
Adaptor Protein ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Neural Stem Progenitor Cells

scholarly journals Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells

Development ◽  
2012 ◽  
Vol 139 (10) ◽  
pp. 1744-1753 ◽  
Author(s):  
S. Afelik ◽  
X. Qu ◽  
E. Hasrouni ◽  
M. A. Bukys ◽  
T. Deering ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Cell Fate ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells

scholarly journals ARS2 is required for retinal progenitor cell S-phase progression and Müller glial cell fate specification

2020 ◽  
Vol 98 (1) ◽  
pp. 50-60 ◽  
Author(s):  
Connor O’Sullivan ◽  
Philip E.B. Nickerson ◽  
Oliver Krupke ◽  
Jennifer Christie ◽  
Li-Li Chen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Progenitor Cells ◽  
Cell Fate ◽  
Cell Cycle Progression ◽  
S Phase ◽  
Cell Fate Specification ◽  
Retinal Progenitor Cells ◽  
Cycle Progression ◽  
Fate Specification ◽  
Retinal Progenitor

During a developmental period that extends postnatally in the mouse, proliferating multipotent retinal progenitor cells produce one of 7 major cell types (rod, cone, bipolar, horizontal, amacrine, ganglion, and Müller glial cells) as they exit the cell cycle in consecutive waves. Cell production in the retina is tightly regulated by intrinsic, extrinsic, spatial, and temporal cues, and is coupled to the timing of cell cycle exit. Arsenic-resistance protein 2 (ARS2, also known as SRRT) is a component of the nuclear cap-binding complex involved in RNA Polymerase II transcription, and is required for cell cycle progression. We show that postnatal retinal progenitor cells (RPCs) require ARS2 for proper progression through S phase, and ARS2 disruption leads to early exit from the cell cycle. Furthermore, we observe an increase in the proportion of cells expressing a rod photoreceptor marker, and a loss of Müller glia marker expression, indicating a role for ARS2 in regulating cell fate specification or differentiation. Knockdown of Flice Associated Huge protein (FLASH), which interacts with ARS2 and is required for cell cycle progression and 3′-end processing of replication-dependent histone transcripts, phenocopies ARS2 knockdown. These data implicate ARS2–FLASH-mediated histone mRNA processing in regulating RPC cell cycle kinetics and neuroglial cell fate specification during postnatal retinal development.

scholarly journals Gene regulatory networks controlling temporal patterning, neurogenesis and cell fate specification in the mammalian retina.

2021 ◽  
Author(s):  
Pin Lyu ◽  
Thanh Hoang ◽  
Clayton P Santiago ◽  
Eric Thomas ◽  
Andrew Timms ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Cell Fate ◽  
Gene Regulatory Networks ◽  
Regulatory Networks ◽  
Cell Fate Specification ◽  
Cell Type ◽  
Temporal Patterning ◽  
Fate Specification ◽  
Expression Of Genes ◽  
Gene Regulatory

Gene regulatory networks (GRNs), consisting of transcription factors and their target cis-regulatory sequences, control neurogenesis and cell fate specification in the developing central nervous system, but their organization is poorly characterized. In this study, we performed integrated scRNA-seq and scATAC-seq analysis from both mouse and human retina to profile dynamic changes in gene expression, chromatin accessibility and transcription factor footprinting during retinal neurogenesis. We identified multiple interconnected, evolutionarily-conserved GRNs consisting of cell type-specific transcription factors that both activate expression of genes within their own network and often inhibit expression of genes in other networks. These GRNs control state transitions within primary retinal progenitors that underlie temporal patterning, regulate the transition from primary to neurogenic progenitors, and drive specification of each major retinal cell type. We confirmed the prediction of this analysis that the NFI transcription factors Nfia, Nfib, and Nfix selectively activate expression of genes that promote late-stage temporal identity in primary retinal progenitors. We also used GRNs to identify additional transcription factors that selectively promote (Insm1/2) and inhibit (Tbx3, Tcf7l1/2) rod photoreceptor specification in postnatal retina. This study provides an inventory of cis- and trans-acting factors that control retinal development, identifies transcription factors that control the temporal identity of retinal progenitors and cell fate specification, and will potentially help guide cell-based therapies aimed at replacing retinal neurons lost due to disease.

scholarly journals Notch mediated patterning and cell fate allocation of pancreatic progenitor cells

2011 ◽  
Vol 356 (1) ◽  
pp. 168
Author(s):  
Solomon Afelik ◽  
Xioling Qu ◽  
Edy Hasrouni ◽  
Michael Bukys ◽  
Stephan Niewoudt ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Cell Fate ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells
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