scholarly journals First person – Daniel V. Guebel

Biology Open ◽  
2021 ◽  
Vol 10 (5) ◽  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
First Person ◽  
Human Hippocampus ◽  
Transcriptomic Changes ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open. Daniel V. Guebel is first author on ‘Mapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment’, published in BiO.

scholarly journals Structural Brain Correlations of Visuospatial and Visuoperceptual Tests in Parkinson’s Disease

2017 ◽  
Vol 24 (1) ◽  
pp. 33-44 ◽  
Author(s):  
Anna Isabel Garcia-Diaz ◽  
Barbara Segura ◽  
Hugo Cesar Baggio ◽  
Maria Jose Marti ◽  
Francesc Valldeoriola ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fractional Anisotropy ◽  
Cortical Thickness ◽  
Cognitive Domains ◽  
Open Question ◽  
Selection Of

AbstractBackground: Diagnosis of mild cognitive impairment in Parkinson’s disease (PD) is relevant because it is a marker for evolution to dementia. However, the selection of suitable tests to evaluate separate cognitive domains in mild cognitive impairment related to PD remains an open question. The current work aims to investigate the neuroanatomical correlates of several visuospatial/visuoperceptual tests using the same sample and a multimodal MRI approach. Methods: The study included 36 PD patients and 20 healthy subjects matched for age, sex, and education. The visuospatial/visuoperceptual tests selected were: Pentagon Copying Test (PCT), Judgment of Line Orientation Test (JLOT), Visual Form Discrimination Test (VFDT), Facial Recognition Test (FRT), Symbol Digit Modalities Test (SMDT), and clock copying task (CLOX2). FreeSurfer was used to assess cortical thickness, and tract-based spatial statistics was used for fractional anisotropy analysis. Results: Lower performance in the PCT, JLOT, and SDMT was associated with extensive cortical thickness reductions in lateral parietal and temporal regions. VFDT and CLOX2 did not show this common pattern and correlated with more limited medial occipito-temporal and occipito-parietal regions. Performance in all visuospatial/visuoperceptual tests correlated with fractional anisotropy in the corpus callosum. Conclusions: Our findings show that JLOT, SDMT, and PCT, in addition to differentiating patients from controls, are suitable visuospatial/visuoperceptual tests to reflect cortical thinning in lateral temporo-parietal regions in PD patients. We did not observe the dissociation between dorsal and ventral streams that was expected according to the neuropsychological classification of visuospatial and visuoperceptual tests. (JINS, 2018, 24, 33–44)

scholarly journals El deterioro cognitivo leve en personas mayores usuarias de centros municipales de la Región de Murcia (España).

2015 ◽  
Vol 32 (1) ◽  
pp. 234
Author(s):  
Andrés Escarbajal De Haro ◽  
Silvia Martínez de Miguel López ◽  
José Romero Sánchez
Keyword(s):  
Quality Of Life ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Elderly People ◽  
Qualitative Methodology ◽  
Self Esteem ◽  
Free Time ◽  
Elderly Users ◽  
Selection Of

This article of investigation tries to know the issue of mild cognitive impairment<strong> (</strong>MCI) in elderly users of municipal centres to measure the importance of psycho-educational dimension like preventive alternative. For this reason, we have used a qualitative methodology (semistructurated interview) after a selection of people applying quantitative scales (e.g. MMSE, EUROTEST and Lawton). We selected a sample of 148 people for the scales, out of which 30 people were considered suitable for the interviews. The results show that despite the fact that elderly people have a MCI , they are able to practice activities for improving their quality of life. Within this investigation, new lines of work based in the free time, lonely, self esteem and self are opened to elderly people with MCI.

scholarly journals Selection of Normative Group Affects Rates of Mild Cognitive Impairment in Parkinson's Disease

2018 ◽  
Vol 33 (5) ◽  
pp. 839-843 ◽  
Author(s):  
Kathryn A. Wyman-Chick ◽  
Phillip K. Martin ◽  
Daniel Weintraub ◽  
Scott A. Sperling ◽  
Lauren O. Erickson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Selection Of

scholarly journals Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture

Aging Cell ◽  
2010 ◽  
Vol 10 (1) ◽  
pp. 103-113 ◽  
Author(s):  
Hafiz Mohmmad Abdul ◽  
Irfan Baig ◽  
Harry LeVine rd ◽  
Rodney P. Guttmann ◽  
Christopher M. Norris
Keyword(s):  
Cell Culture ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Primary Cell Culture ◽  
Primary Cell ◽  
Human Hippocampus

scholarly journals Mapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment

Biology Open ◽  
2021 ◽  
Author(s):  
Daniel V. Guebel ◽  
Néstor V. Torres ◽  
Ángel Acebes
Keyword(s):  
Endothelial Cells ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Abilities ◽  
Vascular System ◽  
Significant Loss ◽  
Data Sets ◽  
Aged Group ◽  
Human Hippocampus ◽  
Stress Changes

Compromise of the vascular system has important consequences on cognitive abilities and neurodegeneration. The identification of the main molecular signatures present in the blood vessels of human hippocampus could provide the basis to understand and tackle these pathologies. As direct vascular experimentation in hippocampus is problematic, we achieved this information by computationally disaggregating publicly available whole microarrays data of human hippocampal homogenates. Three conditions were analysed: Young adults, Aged, and Aged with Mild Cognitive Impairment (MCI). The genes identified were contrasted against two independent data-sets. Here we show that the endothelial cells from the Younger Group appeared in an “activated stage”. In turn, in the Aged Group, the endothelial cells showed a significant loss of response to shear stress, changes in cell adhesion molecules, increased inflammation, brain-insulin resistance, lipidic alterations, and changes in the extracellular matrix. Some specific changes in the MCI Group were also detected. Noticeably, in this study the features arisen from the Aged Group (high tortuosity, increased bifurcations, and smooth muscle proliferation), pose the need for further experimental verification to discern between the occurrence of arteriogenesis and/or vascular remodelling by capillary arterialization.

Sign in / Sign up

Export Citation Format

Share Document