scholarly journals Long-term sucrose solution consumption causes metabolic alterations and affects hepatic oxidative stress in Wistar rats

Biology Open ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. bio047282
Author(s):  
Ellen Mayara Souza Cruz ◽  
Juliana Maria Bitencourt de Morais ◽  
Carlos Vinícius Dalto da Rosa ◽  
Mellina da Silva Simões ◽  
Jurandir Fernando Comar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Sucrose Solution ◽  
Metabolic Alterations ◽  
Hepatic Oxidative Stress

scholarly journals Cerebral cortex damage induced by acute oral alcohol intake is associated with oxidative stress in Wistar rats (Rattus norvegicus)

2018 ◽  
Vol 7 (1) ◽  
pp. 1113-1120
Author(s):  
Eweoya Olugbenga Olawale ◽  
Ayuba Lolo Shunom ◽  
Ajayi Abayomi
Keyword(s):  
Oxidative Stress ◽  
Cerebral Cortex ◽  
Wistar Rats ◽  
Alcohol Intake ◽  
Structural Changes ◽  
Sucrose Solution ◽  
Neuronal Loss ◽  
Acetylcholinesterase Activity ◽  
Alcoholic Solution ◽  
Control Group

The prefrontal cortex undergoes functional and structural changes due to binge or chronic alcohol consumption. This study examines alcohol-induced cerebral cortex damage and the association with oxidative stress in an animal model. Twenty-four Wistar rats (12 males and 12 females) weighing 150g to 250g were divided into four groups, A, B, C and D according to their weights. The rats in groups B, C and D were administered with 2mls of 52.5%, 16.5% and 4.3% v/v aqueous alcoholic solution respectively for 21 days. While rats in group A (control group) were given distilled water only, for the same period. The brain of each rat was excised, weighed and fixed in 10% formal saline for histological analysis while others were immersed in ice cold 30% sucrose solution, homogenized and analyzed for superoxide dismutase, malondialdehyde and acetylcholinesterase activity. Results indicate chromatolysis of Nissl bodies, cortical necrosis, and uneven neuronal loss with varying range of vacuolations in the prefrontal cortices of the alcohol treated rats in a dosedependent manner when compared with the control group. Cerebral cortex damage due to acute oral alcohol intake is associated with oxidative stress.Keywords: Brain, cerebral cortex, alcohol, Wistar rats, oxidative stress

scholarly journals The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
António Nogueira ◽  
Francisco Peixoto ◽  
Maria Manuel Oliveira ◽  
Carlos André Pires ◽  
Bruno Colaço ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Function ◽  
Renal Mass ◽  
Wistar Rats ◽  
Reduced Glutathione ◽  
Mass Reduction ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
And Oxidative Stress

Purpose.This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in a model of renal mass reduction.Methods. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment(n=14); RMR + CAA: RMR rats treated with CAA(n=13); SO: SO rats without treatment(n=13); and SO + CAA: SO rats treated with CAA(n=13). CAA was intraperitoneally administered in a dose of 0.23 µg/Kg three times a week for six months.Results.RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity(p<0.05)and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAA administration significantly increased catalase and GR activity(p<0.05)and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio. No significant differences were found between the RMR groups in any of the parameters of renal function. However, CAA administration slightly improves some parameters of renal function.Conclusions.These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress.

Hepatic Oxidative Stress and Haematological Parameters of Wistar Rats Following Infusion of Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

2018 ◽  
Vol 8 (1) ◽  
pp. 29-36
Author(s):  
Okey Alphonsus Ojiako ◽  
Paul Chidoka Chikezie ◽  
Doris Ifeyinwa Ukairo ◽  
Chiedozie Onyejiaka Ibegbulem ◽  
Reginald Nwazue Nwaoguikpe
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Haematological Parameters ◽  
Hepatic Oxidative Stress

Long-term mequindox treatment induced endocrine and reproductive toxicity via oxidative stress in male Wistar rats

2011 ◽  
Vol 252 (3) ◽  
pp. 281-288 ◽  
Author(s):  
Awais Ihsan ◽  
Xu Wang ◽  
Zhaoying Liu ◽  
Yulian Wang ◽  
Xianju Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Male Wistar Rats

Hepatic Oxidative Stress During Aging: Effects of 8% Long-Term Calorie Restriction and Lifelong Exercise

2006 ◽  
Vol 8 (3-4) ◽  
pp. 529-538 ◽  
Author(s):  
Arnold Y. Seo ◽  
Tim Hofer ◽  
Bokyung Sung ◽  
Sharon Judge ◽  
Hae Y. Chung ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Calorie Restriction ◽  
Aging Effects ◽  
Hepatic Oxidative Stress ◽  
Lifelong Exercise

scholarly journals Lead-Induced Motor Dysfunction Is Associated with Oxidative Stress, Proteome Modulation, and Neurodegeneration in Motor Cortex of Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Luana Ketlen Reis Leão ◽  
Leonardo Oliveira Bittencourt ◽  
Ana Carolina Alves Oliveira ◽  
Priscila Cunha Nascimento ◽  
Maria Karolina Martins Ferreira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Motor Cortex ◽  
Wistar Rats ◽  
Toxic Metal ◽  
Bioinformatic Analysis ◽  
Motor Dysfunction ◽  
Motor Deficits ◽  
Proteomic Profile ◽  
Adult Rats

Lead (Pb) is a toxic metal with great neurotoxic potential. The aim of this study was to investigate the effects of a long-term Pb intoxication on the global proteomic profile, oxidative biochemistry and neuronal density in motor cortex of adult rats, and the possible outcomes related to motor functions. For this, Wistar rats received for 55 days a dose of 50 mg/Kg of Pb acetate by intragastric gavage. Then, the motor abilities were evaluated by open field and inclined plane tests. To investigate the possible oxidative biochemistry modulation, the levels of pro-oxidant parameters as lipid peroxidation and nitrites were evaluated. The global proteomic profile was evaluated by ultraefficiency liquid chromatography system coupled with mass spectrometry (UPLC/MS) followed by bioinformatic analysis. Moreover, it was evaluated the mature neuron density by anti-NeuN immunostaining. The statistical analysis was performed through Student’s t -test, considering p < 0.05 . We observed oxidative stress triggering by the increase in malonaldehyde and nitrite levels in motor cortex. In the proteomic analysis, the motor cortex presented alterations in proteins associated with neural functioning, morphological organization, and neurodegenerative features. In addition, it was observed a decrease in the number of mature neurons. These findings, associated with previous evidences observed in spinal cord, cerebellum, and hippocampus under the same Pb administration protocol, corroborate with the motor deficits in the rats towards Pb. Thus, we conclude that the long-term administration to Pb in young Wistar rats triggers impairments at several organizational levels, such as biochemical and morphological, which resulted in poor motor performance.

Sign in / Sign up

Export Citation Format

Share Document