scholarly journals Multiple tests of association with biological annotation metadata

2008 ◽  
pp. 153-218 ◽  
Author(s):  
Sandrine Dudoit ◽  
Sündüz Keleş ◽  
Mark J. van der Laan
Keyword(s):  
Multiple Tests ◽  
Tests Of Association

scholarly journals Experts’ opinion on the detection and management of prediabetes in Lebanon

2021 ◽  
Vol 104 (3) ◽  
pp. 003685042110294
Author(s):  
Emile Andari ◽  
Paola Atallah ◽  
Sami Azar ◽  
Akram Echtay ◽  
Selim Jambart ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preliminary Report ◽  
Early Stage ◽  
National Guidelines ◽  
Lifestyle Modifications ◽  
Multiple Tests ◽  
Lebanese Population ◽  
To Come ◽  
Near Future

Given that the complications of type 2 diabetes can start at an early stage, early detection and appropriate management of prediabetes are essential. We aimed to develop an expert opinion on prediabetes in Lebanon to pave the way for national guidelines tailored for the Lebanese population in the near future. A panel of seven diabetes experts conducted a thorough literature review and discussed their opinions and experiences before coming up with a set of preliminary recommendations for the detection and management of prediabetes in Lebanon. Lebanese physicians employ multiple tests for the diagnosis of prediabetes and no national cut-off values exist. The panel agreed that prediabetes screening should be focused on patients exceeding 45 years of age with otherwise no risk factors and on adults with risk factors. The panel reached that fasting plasma glucose (FPG) and HbA1c should be used for prediabetes diagnosis in Lebanon. FPG values of 100–125 mg/dL or HbA1c values of 5.7%–6.4% were agreed upon as indicative of prediabetes. For the management of prediabetes, a three-step approach constituting lifestyle modifications, pharmacological treatment and bariatric surgery is recommended. There should be more focus on research on prediabetes in Lebanon. This preliminary report will be further discussed with the Lebanese Society of Endocrinology, Diabetes and Lipids in 2021 in order to come up with the first Lebanese national guidelines for the detection and management of prediabetes in Lebanon.

scholarly journals In search of a Goldilocks zone for credible AI

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kevin Allan ◽  
Nir Oren ◽  
Jacqui Hutchison ◽  
Douglas Martin
Keyword(s):  
Social Cognition ◽  
Single Source ◽  
Multiple Tests ◽  
The Social ◽  
New Directions ◽  
Global Problems ◽  
Scene Content ◽  
Different Sources ◽  
Source Accuracy

AbstractIf artificial intelligence (AI) is to help solve individual, societal and global problems, humans should neither underestimate nor overestimate its trustworthiness. Situated in-between these two extremes is an ideal ‘Goldilocks’ zone of credibility. But what will keep trust in this zone? We hypothesise that this role ultimately falls to the social cognition mechanisms which adaptively regulate conformity between humans. This novel hypothesis predicts that human-like functional biases in conformity should occur during interactions with AI. We examined multiple tests of this prediction using a collaborative remembering paradigm, where participants viewed household scenes for 30 s vs. 2 min, then saw 2-alternative forced-choice decisions about scene content originating either from AI- or human-sources. We manipulated the credibility of different sources (Experiment 1) and, from a single source, the estimated-likelihood (Experiment 2) and objective accuracy (Experiment 3) of specific decisions. As predicted, each manipulation produced functional biases for AI-sources mirroring those found for human-sources. Participants conformed more to higher credibility sources, and higher-likelihood or more objectively accurate decisions, becoming increasingly sensitive to source accuracy when their own capability was reduced. These findings support the hypothesised role of social cognition in regulating AI’s influence, raising important implications and new directions for research on human–AI interaction.

scholarly journals A case study of a conservation flagship species: the monarch butterfly

2021 ◽  
Author(s):  
Stephanie D. Preston ◽  
Julia D. Liao ◽  
Theodore P. Toombs ◽  
Rainer Romero-Canyas ◽  
Julia Speiser ◽  
...  
Keyword(s):  
Mixed Methods ◽  
Empirical Study ◽  
Positive Emotions ◽  
Monarch Butterfly ◽  
Mixed Methods Study ◽  
Flagship Species ◽  
Mass Migration ◽  
Tests Of Association ◽  
And Migration

AbstractWhat makes a flagship species effective in engaging conservation donors? Large, charismatic mammals are typically selected as ambassadors, but a few studies suggest butterflies—and monarchs in particular—may be even more appealing. To gather more information about people’s responses to monarchs, we conducted an empirical study of member submissions to a successful conservation campaign, the Monarch Story Campaign, conducted by the Environmental Defense Fund (EDF). The set of 691 stories along with their associated demographic and donation data was analyzed in a mixed-methods study using qualitative analysis and tests of association. The results showed that people often described encounters with monarchs in childhood and as adults. They expressed strong, positive emotions, and lauded the monarch’s beauty and other “awe-inspiring” qualities and expressed wonder at their lifecycle (i.e., metamorphosis and migration). They also raised conservation themes of distress at monarch loss, calls for action, and caretaking, such as being “fragile” and “in need.” Sharing personal encounters was associated with current efforts to save the species and more past financial donations, while a second pattern tied more donations to awe at the monarch’s mass migration. These results imply that conservation campaigns built around species people encounter may build lifelong awareness, concern, and actions towards conservation.

scholarly journals ID Learning Unit: Understanding and Interpreting Testing for Clostridium difficile

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Daniel A. Solomon ◽  
Danny A. Milner
Keyword(s):  
Clinical Practice ◽  
Clostridium Difficile ◽  
Basic Principles ◽  
Multiple Tests ◽  
Molecular Tests ◽  
Different Types

Abstract Understanding and interpreting the molecular tests for Clostridium difficile is challenging because there are several different types of assays and most laboratories combine multiple tests in order to assess for presence of disease. This learning unit demonstrates the basic principles of each test along with its strengths and weaknesses, and illustrates how the tests are used in clinical practice.

Evaluation of the statistical power for multiple tests: a case study

2009 ◽  
Vol 8 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Adeline Yeo ◽  
Yongming Qu
Keyword(s):  
Statistical Power ◽  
Multiple Tests

p Value Adjustments for Multiple Tests in Multivariate Binomial Models

1989 ◽  
Vol 84 (407) ◽  
pp. 780 ◽  
Author(s):  
Peter H. Westfall ◽  
S. Stanley Young
Keyword(s):  
P Value ◽  
Multiple Tests ◽  
Binomial Models

scholarly journals fNIRS Outcomes for a Pilot Clinical Trial Combining Frontal tDCS With Walking Rehabilitation in Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 792-793
Author(s):  
David Clark ◽  
Sudeshna Chatterjee ◽  
Jared Skinner ◽  
Paige Lysne ◽  
Samuel Wu ◽  
...  
Keyword(s):  
Older Adults ◽  
Executive Function ◽  
Outcome Measures ◽  
Near Infrared ◽  
Neural Circuits ◽  
Functional Near Infrared Spectroscopy ◽  
Active Complex ◽  
Multiple Tests ◽  
Walking Rehabilitation ◽  
Primary Hypothesis

Abstract This pilot study assessed a novel intervention to enhance both walking and executive function in older adults. The primary hypothesis was that eighteen sessions of frontal lobe tDCS combined with walking rehabilitation would be feasible, safe, and show preliminary efficacy. Eighteen participants were randomized to one of three intervention groups: active tDCS and rehabilitation with complex walking tasks (Active/Complex); sham tDCS and rehabilitation with complex walking tasks (Sham/Complex); or sham tDCS and rehabilitation with typical walking (Sham/Typical). Outcome measures included multiple tests of walking function, executive function, and prefrontal activity during walking as measured by functional near infrared spectroscopy (fNIRS). Of the three groups, the Active/Complex group demonstrated the broadest improvements across outcome measures including for prefrontal activity. The functional range of prefrontal activity in this group was increased considerably, as conceptualized by the Compensation Related Utilization of Neural Circuits Hypothesis. Frontal tDCS is a promising adjuvant to walking rehabilitation.

scholarly journals Evaluating the impact of genotype errors on rare variant tests of association

2014 ◽  
Vol 5 ◽  
Author(s):  
Kaitlyn Cook ◽  
Alejandra Benitez ◽  
Casey Fu ◽  
Nathan Tintle
Keyword(s):  
Rare Variant ◽  
Tests Of Association ◽  
The Impact
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