Rationale of Dead Space Measurement by Volumetric Capnography

2012 ◽  
Vol 114 (4) ◽  
pp. 866-874 ◽  
Author(s):  
Gerardo Tusman ◽  
Fernando Suarez Sipmann ◽  
Stephan H. Bohm
2014 ◽  
Vol 45 (6) ◽  
pp. 1704-1716 ◽  
Author(s):  
H. Thomas Robertson

An elevated physiological dead space, calculated from measurements of arterial CO2 and mixed expired CO2, has proven to be a useful clinical marker of prognosis both for patients with acute respiratory distress syndrome and for patients with severe heart failure. Although a frequently cited explanation for an elevated dead space measurement has been the development of alveolar regions receiving no perfusion, evidence for this mechanism is lacking in both of these disease settings. For the range of physiological abnormalities associated with an increased physiological dead space measurement, increased alveolar ventilation/perfusion ratio (V′A/Q′) heterogeneity has been the most important pathophysiological mechanism. Depending on the disease condition, additional mechanisms that can contribute to an elevated physiological dead space measurement include shunt, a substantial increase in overall V′A/Q′ ratio, diffusion impairment, and ventilation delivered to unperfused alveolar spaces.


2011 ◽  
Vol 37 (8) ◽  
pp. 1397-1398 ◽  
Author(s):  
Gerardo Tusman ◽  
Fernando Suarez Sipmann ◽  
Joao B. Borges ◽  
Göran Hedenstierna ◽  
Stephan H. Bohm

CHEST Journal ◽  
2005 ◽  
Vol 128 (4) ◽  
pp. 2195-2202 ◽  
Author(s):  
Kerstin Hogg ◽  
Deborah Dawson ◽  
Ted Tabor ◽  
Beverly Tabor ◽  
Kevin Mackway-Jones

2011 ◽  
Vol 37 (5) ◽  
pp. 870-874 ◽  
Author(s):  
Gerardo Tusman ◽  
Fernando Suarez Sipmann ◽  
Joao B. Borges ◽  
Göran Hedenstierna ◽  
Stephan H. Bohm

Author(s):  
Gerardo Tusman ◽  
Fernando Suarez-Sipmann ◽  
João B. Borges ◽  
Göran Hedenstierna ◽  
Stephan H. Bohm

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