Effects of histamine H2-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide

2002 ◽  
Vol 54 (11) ◽  
pp. 1559-1563 ◽  
Author(s):  
Hiroki Itoh ◽  
Takafumi Naito ◽  
Masaharu Takeyama
Keyword(s):  
Substance P ◽  
Human Plasma ◽  
Vasoactive Intestinal Peptide ◽  
Plasma Levels ◽  
Calcitonin Gene Related Peptide ◽  
H2 Receptor Antagonists ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Related Peptide ◽  
Calcitonin Gene

Plasma levels of vasoactive neuropeptides in pediatric patients with migraine during attack and attack-free periods

Cephalalgia ◽  
2020 ◽  
pp. 033310242095758
Author(s):  
Fatma Hanci ◽  
Yasemin Baranoglu Kilinc ◽  
Erkan Kilinc ◽  
Sevim Turay ◽  
Mustafa Dilek ◽  
...  
Keyword(s):  
Substance P ◽  
Vasoactive Intestinal Peptide ◽  
Plasma Levels ◽  
Migraine Without Aura ◽  
Pediatric Patients ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Pediatric Migraine ◽  
Calcitonin Gene ◽  
Significant Difference

Background Increasing evidence suggests that vasoactive neuropeptides such as pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38), substance P, calcitonin gene-related peptide, and vasoactive intestinal peptide are involved in the pathophysiology of migraine in adults, but their role in pediatric migraineurs remains unclear. We prospectively investigated plasma levels of these vasoactive neuropeptides in pediatric migraine patients without aura and compared the results with those of age-matched healthy controls. Methods Thirty-eight children aged 6–18 years with migraine without aura and 20 age-matched control subjects were included in the study. Neuropeptides in plasma samples from the controls, and in either the ictal or interictal periods in pediatric migraine without aura, were measured using ELISA. Results PACAP-38 and vasoactive intestinal peptide levels in both ictal and interictal plasma were higher in the patients with pediatric migraine without aura than in the controls ( p < 0.001), although calcitonin gene-related peptide and substance P levels remained unchanged. Otherwise, no significant difference was determined between ictal and interictal periods in terms of all neuropeptide levels. Conclusions This study demonstrates increased plasma PACAP-38 and vasoactive intestinal peptide levels, but not calcitonin gene-related peptide and substance P levels, in pediatric patients with migraine during both attack and attack-free periods. The study findings suggest that PACAP-38 and vasoactive intestinal peptide may be implicated in the pathophysiology of migraine, particularly in pediatric migraineurs.

Ecabet sodium raises plasma levels of calcitonin gene-related peptide and substance P in healthy humans

2005 ◽  
Vol 57 (6) ◽  
pp. 799-805 ◽  
Author(s):  
Fumihiko Katagiri ◽  
Shin Inoue ◽  
Yuhki Sato ◽  
Hiroki Itoh ◽  
Masaharu Takeyama
Keyword(s):  
Substance P ◽  
Plasma Levels ◽  
Calcitonin Gene Related Peptide ◽  
Ecabet Sodium ◽  
Related Peptide ◽  
Healthy Humans ◽  
Calcitonin Gene

Effects of the three neuropeptides, vasoactive intestinal peptide, substance P, and calcitonin gene related peptide on basal and stimulated calcitonin release in the rat

1987 ◽  
Vol 115 (3) ◽  
pp. 297-300 ◽  
Author(s):  
B. Månsson ◽  
B. Ahrén ◽  
A. Nobin
Keyword(s):  
Substance P ◽  
Vasoactive Intestinal Peptide ◽  
Calcium Chloride ◽  
Single Injection ◽  
Peak Plasma ◽  
Calcitonin Gene Related Peptide ◽  
C Cells ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Calcitonin Secretion

Abstract. Calcitonin is secreted from the thyroidal C-cells. Except that calcitonin secretion is stimulated by calcium, little is known of its regulation. Vasoactive intestinal peptide (VIP), substance P, and calcitonin gene related peptide (CGRP) have recently been detected within intrathyroidal neurons, and CGRP also within the C-cells, and may therefore affect calcitonin secretion. In this study, we investigated whether VIP, substance P or CGRP could influence calcitonin secretion in the rat. Each of these peptides was administered as a single injection (1.5 nmol/animal) or as a 30-min infusion (1.5 nmol/animal per 30 min) during which calcium chloride, 456 μmol/animal, was injected iv. We found that the peptides had no effect on basal calcitonin secretion, but that VIP potentiated the calcium-induced calcitonin release. Thus, the peak plasma calcitonin level following calcium chloride injection was doubled by the infusion of VIP (P < 0.001). In contrast, neither substance P nor CGRP significantly influenced the calcium-induced calcitonin release. We conclude that VIP, a neuropeptide within intrathyroidal nerves, has the capacity to augment calcium-induced calcitonin secretion in the rat and we therefore suggest that VIP is a regulator of calcitonin secretion.

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