Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes

1995 ◽  
Vol 9 (3) ◽  
pp. 340-349 ◽  
Author(s):  
Y. Zhao
Keyword(s):  
Stromal Cells ◽  
Adipose Stromal Cells ◽  
Aromatase Gene ◽  
Fetal Hepatocytes

scholarly journals Mechanical Characterization of Extracellular Vesicles Derived from Immortalized Adipose Stromal Cells

2020 ◽  
Vol 118 (3) ◽  
pp. 252a
Author(s):  
Melissa C. Piontek ◽  
Sourav Maity ◽  
Linda A. Brouwer ◽  
Martin C. Harmsen ◽  
Wouter H. Roos
Keyword(s):  
Extracellular Vesicles ◽  
Stromal Cells ◽  
Mechanical Characterization ◽  
Adipose Stromal Cells

Tumor suppressor BRCA1 inhibits a breast cancer-associated promoter of the aromatase gene (CYP19) in human adipose stromal cells

2007 ◽  
Vol 292 (1) ◽  
pp. E246-E252 ◽  
Author(s):  
Sagar Ghosh ◽  
Yunzhe Lu ◽  
Adam Katz ◽  
Yanfen Hu ◽  
Rong Li
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Tumor Suppressor ◽  
Stromal Cells ◽  
Breast Cancer Susceptibility Gene ◽  
Adipose Stromal Cells ◽  
Aromatase Expression ◽  
Aromatase Gene ◽  
Estrogen Production ◽  
Estrogen Biosynthesis

Adipose tissue provides an important extragonadal source of estrogen. Obesity-associated elevation of estrogen production increases risk of breast cancer in postmenopausal women. Aromatase ( CYP19), which converts androgen to estrogen, is a key enzyme in estrogen biosynthesis. In normal adipose tissue, transcription of the aromatase gene is initiated from a relatively weak adipose-specific promoter (I.4). However, in breast cancer, a switch of promoter utilization from I.4 to a strong ovary-specific promoter, PII, leads to increased aromatase expression and, hence, elevated estrogen production. Here, we report an intriguing relationship between the breast cancer susceptibility gene BRCA1 and aromatase expression in human adipose stromal cells (ASCs). Upon stimulation by phorbol ester or dexamethasone, increased aromatase expression in ASCs was accompanied by significant reduction of the BRCA1 level. In addition, adipogenesis-induced aromatase expression was also inversely correlated with BRCA1 abundance. Downregulation of BRCA1 expression in response to various stimuli was through distinct transcription or posttranscription mechanisms. Importantly, siRNA-mediated knockdown of BRCA1 led to specific activation of the breast cancer-associated PII promoter. Therefore, in addition to its well-characterized activities in breast epithelial cells, a role of BRCA1 in modulation of estrogen biosynthesis in ASCs may also contribute to its tissue-specific tumor suppressor function.

scholarly journals Prostaglandin E2 Inhibits p53 in Human Breast Adipose Stromal Cells: A Novel Mechanism for the Regulation of Aromatase in Obesity and Breast Cancer

2015 ◽  
Vol 75 (4) ◽  
pp. 645-655 ◽  
Author(s):  
Xuyi Wang ◽  
Maria M. Docanto ◽  
Hironobu Sasano ◽  
Camden Lo ◽  
Evan R. Simpson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prostaglandin E2 ◽  
Stromal Cells ◽  
Human Breast ◽  
Adipose Stromal Cells ◽  
Breast Adipose

New potential agents for cryopreservation of hematopoietic and adipose stromal cells

Cytotherapy ◽  
2014 ◽  
Vol 16 (4) ◽  
pp. S58
Author(s):  
J. Svalgaard ◽  
E. Haastrup ◽  
A. Brink ◽  
C. Clausen ◽  
B. Holst ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Adipose Stromal Cells

Characterization of the immunomodulatory effect in vitro of microvesicles isolated from mesenchymal stromal cells on immune cells

2013 ◽  
Vol 41 (8) ◽  
pp. S64
Author(s):  
Antonella Conforti ◽  
Marco Scarsella ◽  
Ezio Giorda ◽  
Simone Biagini ◽  
Nadia Starc ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Immune Cells ◽  
Stromal Cells ◽  
Immunomodulatory Effect
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