scholarly journals A New, Lineage Specific, Autoup-Regulation Mechanism for Human Glucocorticoid Receptor Gene Expression in 697 Pre-B-Acute Lymphoblastic Leukemia Cells

2011 ◽  
Vol 25 (1) ◽  
pp. 44-57 ◽  
Author(s):  
Chuan-dong Geng ◽  
Wayne V. Vedeckis
Keyword(s):  
Gene Expression ◽  
Acute Lymphoblastic Leukemia ◽  
Glucocorticoid Receptor ◽  
Lymphoblastic Leukemia ◽  
Receptor Gene ◽  
Leukemia Cells ◽  
Regulation Mechanism ◽  
Glucocorticoid Receptor Gene ◽  
Receptor Gene Expression

Lower glucocorticoid receptor gene expression and glucocorticoid receptor variants are associated with cocaine use and addiction

2017 ◽  
Vol 83 ◽  
pp. 81 ◽  
Author(s):  
Andrea B. Schote ◽  
Kristina Jäger ◽  
Sara L. Kroll ◽  
Matthias Vonmoos ◽  
Lea M. Hulka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Glucocorticoid Receptor ◽  
Receptor Gene ◽  
Cocaine Use ◽  
Glucocorticoid Receptor Gene ◽  
Receptor Gene Expression

Pharmacogenetics of Response to Glucocorticosteroids in Adults with Acute Lymphoblastic Leukemia.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 2609-2609
Author(s):  
Krzysztof Jamroziak ◽  
Ewa Balcerczak ◽  
Zofia Szemraj ◽  
Aleksandra Salagacka ◽  
Olga Grzybowska-Izydorczyk ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Complete Remission ◽  
Glucocorticoid Receptor ◽  
Induction Chemotherapy ◽  
Direct Sequencing ◽  
Lymphoblastic Leukemia ◽  
Receptor Gene ◽  
Prognostic Impact ◽  
Functional Polymorphisms ◽  
Glucocorticoid Receptor Gene

Abstract Glucocorticoids are crucial components of standard chemotherapy regimens used for the treatment of adult acute lymphoblastic leukemia (ALL). However, little is known on significance of the inherited genetic background for response to steroids in adult ALL. We hypothesized that functional single nucleotide polymorphisms (SNPs) in genes important for steroid pharmacokinetics and pharmacodynamics may contribute to sensitivity or resistance to steroids. In this study we investigated whether analysis of common functional SNP in drug transporter P-glycoprotein gene (MDR1 or ABCB1), phase I cytochrome P450A metabolizing enzymes genes (CYP3A4 and CYP3A5) and glucocorticoid receptor gene NR3C1 can be useful to predict response to induction chemotherapy and survival of adult ALL patients. Sixty-two uniformly treated adult ALL patients were investigated for 6 common SNPs affecting steroid pathway including MDR1 exon 26 C3435T, CYP3A4*1B, CYP3A5*3, CYP3A5*6, NR3C1 bcl I and NR3C1 N363S polymorphisms. Genotypes were identified using direct sequencing or restriction fragment length polymorphism (RFLP) method. In the genotyped cohort 60% patients achieved complete remission after first induction chemotherapy. The analysis of the prognostic impact of the genotyped SNPs on treatment response showed that carriers of the glucocorticoid receptor NR3C1 gene 363S allele had a significantly greater probability of achievement of complete remission as compared to the non-carriers, odds ratio(OR)=1.23, 95% confidence interval (95%CI) = 1.02 −1.47, p=0.042). None of the analyzed polymorphic variants showed significant impact on probability of progression-free and overall survival of the included patients. In conclusion, we found that glucocorticoid receptor NR3C1 gene N363S polymorphism contributes to the response to steroids in patients with adult ALL. Inherited functional polymorphisms in pharmacokinetic pathways of anti-leukemic drugs should be considered as determinants of response potentially useful for individualization of chemotherapy of adult ALL of in the future.

Polymorphisms in glucocorticoid receptor gene and the outcome of childhood acute lymphoblastic leukemia (ALL)

2010 ◽  
Vol 34 (4) ◽  
pp. 492-497 ◽  
Author(s):  
Malgorzata Labuda ◽  
Annabel Gahier ◽  
Vincent Gagné ◽  
Albert Moghrabi ◽  
Daniel Sinnett ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Glucocorticoid Receptor ◽  
Lymphoblastic Leukemia ◽  
Receptor Gene ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Glucocorticoid Receptor Gene
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